New combo therapy aims to cut deaths in HIV patients with widespread TB
NCT ID NCT04951986
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving higher doses of a TB drug (rifampicin) plus an extra antibiotic (levofloxacin) for 14 days, with or without steroids, can help more people survive. It includes 732 adults with HIV who are hospitalized for TB that has spread beyond the lungs. The goal is to find a better way to control the disease and reduce deaths.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Khayelitsha Hospital, c/o Steve Biko and Walter Sisulu Drives, Khayelitsha
Cape Town, Western Cape, 7784, South Africa
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Mitchells Plain Hospital, Mitchells PLain
Cape Town, Western Cape, 7785, South Africa
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