Could antibody infusions help prevent HIV? new trial begins
NCT ID NCT06812494
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether a combination of three lab-made antibodies is safe and tolerable in 200 healthy adults without HIV. Participants receive one or more IV infusions of the antibodies and are followed for 18 months. The goal is to see if this approach could eventually be used to prevent or control HIV infection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
three lab-made antibodies (VRC07-523LS, PGT121.414.LS, PGDM1400LS) given by IV infusion
What this could lead to
If successful, this could point toward a new way to prevent or control HIV using infusions of antibodies instead of daily pills.
What could go wrong
This is an early phase 2 trial focused on safety, so it is not yet testing whether the antibodies actually prevent HIV. The antibodies may not work as hoped, and side effects are possible.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HIV are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
ACSA CRS
NOT_YET_RECRUITINGIquitos, Maynas, 1, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Alabama CRA (Site #31788)
RECRUITINGBirmingham, Alabama, 35222, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
BIDMC VCRS (Site ID# 32077)
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Bridge HIV, San Francisco Department of Public Health
RECRUITINGSan Francisco, California, 94102, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Brigham and Women's Hospital Vaccine CRS (BWH VCRS)
RECRUITINGBoston, Massachusetts, 02115-6110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CITBM CRS (Site ID 31970)
RECRUITINGCallao, 15081, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Chapel Hill CRS (Site #3201)
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Chatsworth CRS
NOT_YET_RECRUITINGChatsworth, KwaZulu-Natal, 4030, South Africa
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Columbia P&S CRS
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Fenway Health
RECRUITINGBoston, Massachusetts, 02215-4302, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Groote Schuur HIV CRS
NOT_YET_RECRUITINGCape Town, Western Cape, 7925, South Africa
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
RECRUITINGRio de Janeiro, 21040-360, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Penn Prevention CRS
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Perinatal HIV Research Unit (PHRU)
NOT_YET_RECRUITINGJohannesburg, Gaunteng, 1862, South Africa
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
San Miguel CRS (Site #11302)
RECRUITINGLima, 32-15088, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Seattle Vaccine and Prevention CRS (Site ID# 30331)
RECRUITINGSeattle, Washington, 98104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Setshaba Research Centre
NOT_YET_RECRUITINGSoshanguve-H, Soshanguve, 0152, South Africa
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
The Hope Clinic of the Emory Vaccine Research Center; Emory University
RECRUITINGDecatur, Georgia, 30030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Pittsburgh CRS (Site 1001)
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Rochester Vaccines to Prevent HIV Infection CRS (Site ID 31467)
RECRUITINGRochester, New York, 14642, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Vanderbilt Vaccine (VV) CRS
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Via Libre (Site ID 31909)
RECRUITINGLima, 15001, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••