Could a common diabetes drug lift depression in HIV patients?

NCT ID NCT07007221

Terminated Symptom relief Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether metformin, a standard diabetes drug, can help treat depression in people living with HIV. Researchers will enroll 600 adults with HIV and depression, giving them metformin, fluoxetine (a standard antidepressant), both, or a placebo for up to 12 weeks. The goal is to see if metformin improves mood and reduces inflammation, potentially offering a new, accessible treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin
What this could lead to: If it works, this could offer a new, affordable way to treat depression in people with HIV, improving both mental health and HIV outcomes.
What could go wrong: This is an early phase 2 trial with multiple parts, so results are uncertain. Depression is complex, and metformin may not work for everyone or may cause side effects.

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Conditions

The condition(s) this trial relates to.

AIDS Depression depressive disorder HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION HIV

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