Old drug, new hope: doxycycline tested for HIV-Related emphysema

NCT ID NCT05382208

Ongoing Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether doxycycline, an antibiotic, can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibiotic resistance.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMPHYSEMA HIV

Contacts and locations

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Locations

Case Western University

Cleveland, Ohio, 44106, United States
Duke University School of Medicine

Durham, North Carolina, 27704, United States
Emory University

Atlanta, Georgia, 30329, United States
Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Miami University

Miami, Florida, 33136, United States
Ohio State University

Columbus, Ohio, 43210, United States
SUNY Downstate Medical School

Brooklyn, New York, 11203, United States
Temple University

Philadelphia, Pennsylvania, 19140, United States
Tulane University

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of California Los Angeles

Los Angeles, California, 90095, United States
University of California San Diego

San Diego, California, 92103, United States
University of Cincinnati College of Medicine

Cincinnati, Ohio, 45267, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15261, United States
University of Texas, McGovern Medical School

Houston, Texas, 77030, United States
University of Washington

Seattle, Washington, 98104, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Weill Cornell Medicine

New York, New York, 10065, United States

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