Could antibiotics save malnourished kids after hospital?
NCT ID NCT05994742
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
Severe acute malnutrition affects millions of children worldwide and often leads to death after hospital discharge. This phase 3 trial tests whether giving a combination of antibiotics (rifampicin, azithromycin, isoniazid, and vitamin B6) for several weeks can lower the risk of death, re-hospitalization, or poor nutritional recovery. About 674 children aged 6–59 months with complicated malnutrition will be enrolled across multiple sites.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rifampicin, Azithromycin, Isoniazid, and Pyridoxine (antibiotics and vitamin B6)
What this could lead to
If successful, this could lead to a simple antibiotic regimen that reduces deaths and hospital stays in malnourished children after discharge.
What could go wrong
This is a single trial with 674 children; results may not apply to all settings. Antibiotics can cause side effects or resistance.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Chitungwiza Central Hospital
Harare, Zimbabwe
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Coast General
Mombasa, Kenya
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Homa Bay
Homa Bay, Kenya
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Matero Hospital
Lusaka, Zambia
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Mbagathi Hospital
Mbagathi, Kenya
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Migori Referral Hospital
Migori, Kenya
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Parirenyatwa Hospital
Harare, Zimbabwe
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Sally Mugabe Hospital
Harare, Zimbabwe
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UTH - University Teaching Hospital
Lusaka, Zambia