HIV

This early-stage study tests two new mRNA vaccines designed to help the immune system fight HIV. About 42 adults with well-controlled HIV will receive the vaccines and then temporarily pause their regular HIV medication under close monitoring. The main goals are to check safety a…

This study looks at whether adding a medication called cytisine to intensive counseling helps people with HIV in Kenya quit smoking and stop heavy drinking. About 300 participants will be followed to see if they can stay smoke-free and avoid heavy alcohol use. The goal is to impr…

This study tests whether a smartphone app (DynamiCare) plus a patient navigator can help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine and start HIV prevention (PrEP) or treatment (ART). The pilot phase will enroll 40 …

This study tests whether alendronate, a drug used for bone loss, can reduce the hidden HIV reservoir in people already on HIV medication. About 30 participants will receive either alendronate or a placebo, and researchers will measure changes in HIV DNA in the blood. The goal is …

This pilot study tests whether a program called Yuva Sath, led by trained peers, can help young people (ages 18-29) who inject drugs in India stay engaged in addiction treatment and use HIV prevention services. Sixty participants will receive one-on-one sessions and weekly text c…

This study tests a program called Coach Mpilo, where men living with HIV are trained to support other men with HIV. The coaches help their peers overcome challenges like stigma, mental health issues, and lack of knowledge to stay on treatment and attend clinic visits. The study w…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their regular addiction medication appointments in one visit. The goal is to make it easier for veterans to get tested and treated for infections …

This study tests whether pharmacy technicians can help more people with HIV receive long-acting injectable medication at community health centers in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to make it easier for patients…

This early-stage study tests an injection called JL18008 in people with HIV whose immune systems haven't fully recovered despite standard treatment. The goal is to safely improve their CD4 cell counts, which help fight infections. About 52 adults will take part to see if the shot…

This study tests a smartphone app called JomCare that provides timely support to men who have sex with men (MSM) to help them reduce risky behaviors linked to chemsex (using drugs before or during sex). The goal is to lower the chance of HIV infection. About 482 HIV-negative or u…

This study tests whether giving young people living with HIV a guaranteed income of $500 per month for 18 months helps them stay in care and achieve viral suppression. About 304 participants aged 18-35 who have faced financial hardship will be randomly assigned to receive either …

This study will test a peer navigation program for 250 people living with HIV who also use substances in Los Angeles County. The program pairs participants with trained peers to help them get to medical appointments and stick with their HIV treatment. The goal is to see if this s…

This study tests whether a smartphone app can help people with HIV in Laos quit smoking better than printed materials. About 1,200 smokers from 8 HIV clinics will take part. The app sends personalized texts, photos, and videos to support quitting. The goal is to see how many peop…

This study tests whether baricitinib, a drug approved for other conditions, can keep HIV under control after participants stop their usual antiretroviral therapy (ART). Twenty people with well-controlled HIV will take baricitinib alongside ART for 26 weeks, then continue bariciti…

This study will enroll 1,500 pregnant women with HIV in Uganda to find the best way to screen for tuberculosis (TB) and the safest time to start TB prevention medicine. Researchers will compare symptom-based screening versus a blood test, and test starting prevention during pregn…

This study looks at whether people with HIV who have stopped taking their medication for at least 12 weeks can safely restart treatment on the same day they return to care. About 200 adults will receive a once-daily pill (B/F/TAF) and be monitored for viral suppression and side e…

This study tests whether a pharmacist-led electronic consultation can help people with HIV use certain lung medications and smoking-cessation aids more appropriately. About 480 participants who smoke or take certain inhalers or acid-reducing pills will receive tailored medication…

This study tests a special microscope that takes high-quality pictures of cervical tissue samples right where the patient is seen. Researchers want to see if it can give doctors the same detailed information as standard lab tests, but much faster. About 400 women in Mozambique an…

This study tests a mobile health program called PrEP Choice to help young people (ages 13-24) start and stick with HIV prevention medication (PrEP). It also looks at whether taking a pill called DoxyPEP after sex can prevent other STIs. About 200 participants at higher risk for H…

This study will test if a text-message program can help 750 young adults (ages 18-22) in Uganda prevent HIV. Participants will receive texts with quizzes, badges, and advice to encourage HIV testing and condom use. The goal is to see if these messages make a difference over 12 mo…

This study will test a personalized decision support tool to help people in emergency departments and urgent care clinics start and continue taking PrEP, a daily pill that prevents HIV. Researchers will enroll 120 HIV-negative adults in Baltimore and Washington, DC, and track how…

This study is testing a smartphone app designed to help Black teenagers and young adults in Alabama stick with their daily HIV prevention medication (PrEP). The app includes features like medication tracking and chat with a support person. Researchers want to see if the app is ea…

This study looks at whether adding a remote nurse via video call and text messages can help more people start and continue taking HIV prevention pills (PrEP and PEP) at pharmacies in Kenya. About 1,580 pharmacy clients will take part. The goal is to see if telehealth support make…

This study tests a program called CUPID that helps couples make decisions together about HIV prevention. About 1,400 women in Uganda will join with their male partners to choose and stick with prevention methods like PrEP pills, rings, or shots. The goal is to see if partner supp…

This study looks at whether offering HIV prevention medication (PrEP) during regular family planning clinic visits works well for patients and doctors. About 83 patients and their physicians will take part. Patients will get counseling and can start PrEP if they want, then fill o…

This study tests whether a mobile app and having a community health worker deliver PrEP (HIV prevention medication) at a place convenient for the participant—like home or a mobile van—helps young people aged 13–24 stick with their PrEP routine. About 272 participants who are HIV-…

This study tests whether offering HIV and STI testing as a routine, opt-out part of primary care visits increases testing and PrEP use among adults aged 18 to 45 in Mississippi. Researchers will compare standard care to an integrated model where testing and PrEP navigation are bu…

This study tests a virtual program called LEARN 2 for men aged 18 and older living with HIV. The goal is to see if it can improve quality of life and reduce risk factors for heart disease and metabolic problems. Participants will use the platform weekly, attend live health educat…

This study tests a program called YACHT to help health clinics in Florida provide better HIV testing and prevention counseling for young men who have sex with men (ages 13-34). The program includes training for staff and secret shoppers to check service quality. Researchers hope …

This study looks at ways to help more Black women get PrEP, a daily pill that prevents HIV. Researchers will work with Planned Parenthood clinics in Illinois to find and support women who are at higher risk. About 250 women will take part, and the goal is to see if new strategies…

This study tests two smartphone tools to help HIV-negative men who have sex with men stick to their daily PrEP medication and reduce methamphetamine use. One app supports PrEP adherence, the other provides cognitive-behavioral therapy for substance use. The study will enroll 100 …

This study tests whether training young people to deliver HIV prevention pills (PrEP) to their peers can increase use and adherence compared to standard clinic care. About 1,400 sexually active youth aged 15-24 in Brazil who are not currently taking PrEP will be randomly assigned…

This study tests a new way to help transgender sex workers and their clients get HIV and STI prevention services. The program uses a digital teleconsultation system called E-PrevenT to make it easier for these often-hidden groups to access care. Researchers will enroll 250 people…

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail access HIV prevention medication (PrEP) and treatment for opioid use disorder. The app provides personalized messages and connects users with a navigator. Researchers will enroll 7…

This study will offer 3700 young people (ages 15-35) in Cape Town a choice of HIV prevention methods, including a new twice-yearly injection called lenacapavir, a two-monthly injection (cabotegravir), or daily pills. Participants can switch methods at any time and will be followe…

This study tests a counseling program called Healthy Families-PrEP that helps women in rural Uganda use HIV prevention pills (PrEP) while trying to get pregnant, during pregnancy, and after giving birth. The goal is to reduce HIV infections in both women and their children. About…

This study tests whether metformin, a diabetes drug, can help treat depression in people living with HIV. Depression is common in HIV and can make it harder to stick with life-saving HIV medication. The trial will enroll 600 adults in Uganda and compare metformin to placebo, and …

This study is testing a new smartphone app called Harmonized Healing, which uses personalized music to help people with HIV manage their chronic pain. Researchers want to see if using the app is practical and acceptable for participants over three months. The study will also comp…

This study is testing whether two different phone-delivered therapies can help older adults with HIV who have trouble sleeping. Researchers will compare a brief insomnia treatment against a mindfulness program to see which one better improves sleep quality and cognitive function …

This study looks at whether an automatic alert in electronic medical records can help primary care doctors order screening tests for HIV, hepatitis B, and hepatitis C together. About 50 doctors will take part, and their patient visits will be randomly assigned to either get the a…

This study works with 80 women with HIV in South Africa who have had an abnormal Pap smear. Researchers will interview patients and providers to understand why some women miss follow-up appointments. Based on what they learn, they will create a support program and test if it help…

This study aims to improve HIV outpatient care by routinely asking patients about their mental health, symptoms, and quality of life through a questionnaire called POSITIVE OUTCOMES. About 17,000 adults with HIV at five clinics in the UK and US will take part. Researchers will wo…

This study tests a short digital messaging program (via Telegram or WhatsApp) to help people who use drugs in Kazakhstan overcome stigma and learn about PrEP, a medicine that prevents HIV. About 40 participants will receive informational messages over 2-3 weeks and complete surve…

This study tests a 12-week online program for HIV-negative Latino men who have sex with men and use methamphetamine. The program teaches coping skills and resilience to reduce meth use risk and help participants take steps toward HIV prevention (PrEP). The study involves 20 parti…

This study tests a program called HEATED-SAIA to improve HIV testing and care in emergency departments across three counties in Kenya. It focuses on reaching men, adolescents, and key populations who often miss testing. The trial will compare hospitals using the program to those …

This study aims to reduce racial bias among pharmacists who prescribe or help with HIV prevention medication (PrEP). Researchers will adapt a bias-reduction program for pharmacists and test if it is practical and effective. About 70 pharmacy interns and experts will take part to …

This study tests whether reducing stigma in healthcare settings can help more providers offer, and more patients receive, important HIV and STI prevention services like testing and cancer screening. The research will take place in eight clinics in the Mississippi Delta, a region …

This study will test two new services at a Chicago health center: routine substance use screening for all patients, and a program that helps people refer friends or partners who may need HIV or addiction care. The goal is to find more people with undiagnosed HIV or substance use …

This study looks at whether adding confidential care to regular pediatric checkups makes it easier for teens aged 13-17 to get tested for HIV. Researchers will work with 4 clinics to see if this approach is practical and acceptable to doctors and staff. The goal is to learn how t…

This study aims to see if a package of interventions—including problem-solving support, nutrition advice, and play activities—can improve brain development and growth in children from birth to age 2. Researchers will enroll 1,260 pregnant women (with and without HIV) in Botswana,…

This study aims to see if a special training program can help doctors in Vietnam treat people with HIV and men who have sex with men more fairly. About 155 doctors will take part, and researchers will measure if the training reduces stigma by comparing care quality before and aft…

This study tests whether a video app called 'Undetectable & You' can help people with HIV in South Africa stay in care and keep the virus under control. The app teaches that people with HIV who have an undetectable viral load cannot pass the virus to others (U=U). About 880 peopl…