HIV

This is a first-in-human, early-stage trial to test the safety and immune response of two new experimental HIV vaccines. The vaccines, called DV201P-RNA and DV202B1-RNA, use mRNA technology (similar to some COVID-19 vaccines) to train the immune system to fight HIV. The study wil…

This study is for adults with HIV who have stopped their medication for at least 12 weeks and want to restart treatment. It tests a faster process where participants begin taking a standard, once-daily HIV pill (B/F/TAF) on the very same day they return to the clinic. Researchers…

This study is testing if treating depression can help prevent a worsening of insulin resistance, a condition that can lead to diabetes, in adults with HIV. Researchers will compare a 9-week online cognitive behavioral therapy program to an educational program about depression. Th…

This study is testing whether alendronate, a medication commonly used for bone health, can reduce the hidden reservoir of HIV in people who are already on effective antiviral therapy. Thirty participants will be randomly assigned to receive either alendronate or a placebo pill, a…

This early-stage study is testing an experimental injection called JL18008 in people living with HIV. It's designed for patients whose immune systems remain weak despite taking effective antiviral medications. The research will first check if the injection is safe, then see if it…

This study aims to improve health for people with HIV or substance use issues at a Chicago community health center. It will add routine substance use screening for all patients and a program where patients can help connect friends or partners who need care. The goal is to find mo…

This study is testing a program designed to help mothers provide better nurturing care for their babies in Botswana, Kenya, and Zimbabwe. It will enroll 1,260 pregnant women, including those living with and without HIV, and follow their children for two years. The program include…

This study aims to see if trained peer guides can help people living with HIV who also use substances stay connected to their medical care in Los Angeles. Researchers will work with 250 participants to test whether having a supportive person who understands their experiences help…

This pilot study is testing a new peer-led support program called Yuva Sath. It aims to help young people in India who inject drugs stay engaged in their treatment and use HIV prevention services. Researchers will compare 60 participants who receive the program to those who do no…

This study is testing a questionnaire that helps people with HIV communicate their concerns about mental health, symptoms, and quality of life during medical appointments. Researchers will work with 17,000 patients across five clinics in the UK and US to see if using this questio…

This study is testing a new support toolkit designed to help people in South Africa stay connected to their HIV care, especially during the first six months after starting medication. The toolkit includes tools to identify who might struggle to stay in care, a menu of support opt…

This study is testing a smartphone app that teaches people with HIV a key fact: if their treatment makes the virus undetectable, they cannot pass it to sexual partners. Researchers want to see if learning this through videos and stories helps people in South Africa stick with the…

This study is testing a new way to provide care for veterans with opioid addiction. It combines addiction treatment with screening and prevention for serious infections like HIV and hepatitis C into a single clinic visit. The goal is to make it easier for veterans to get all the …

This study aims to find the best way to help people living with HIV in Kenya quit smoking and cut back on heavy drinking. It will test a combination of intensive counseling and a medication called cytisine. The goal is to improve long-term health outcomes for 300 participants who…

This study tests whether baricitinib, a drug that reduces inflammation, can delay the return of HIV after people stop their regular antiretroviral therapy. Researchers will give 20 adults with well-controlled HIV the drug alongside their usual treatment for 26 weeks, then have th…

This study is testing whether the medication semaglutide can help adults living with HIV drink less alcohol and smoke fewer cigarettes. Researchers want to see if reducing these habits also lowers the risk of heart disease in this population. About 200 participants will take eith…

This study is testing a mobile phone app called DynamiCare to see if it can help people recently released from jail or prison. The app provides rewards for staying drug-free and connects users with a personal guide to help them start HIV prevention or treatment medications. The g…

This study is testing a new type of microscope called DeepDOF. It takes high-quality digital images of cervical tissue samples right after they are collected. The goal is to see if these images can help doctors diagnose cervical cancer and pre-cancer as accurately as standard lab…

This study is testing if a simple computer alert can help doctors screen more patients for HIV, hepatitis B, and hepatitis C. When a doctor orders a test for one of these viruses, the alert will suggest adding tests for all three. The goal is to find more infections earlier by ma…

This study is testing whether a specially designed mobile phone app can help young men who have sex with men better manage their HIV risk and care. It will compare two groups: one that gets immediate access to the app for 12 months, and another that gets delayed access. The main …

This study aims to see if a new community-based telehealth model can help more people get access to PrEP, a daily pill that prevents HIV. Researchers will partner with local community organizations to offer telehealth navigation for PrEP and compare it to the standard online sign…

This study aims to improve how clinics in Florida test for HIV and connect young men to prevention medication (PrEP). Researchers will test a new training package for clinic staff across 42 locations. They will measure if the training leads to more HIV tests and better quality co…

This study aims to see how well a new, long-acting injectable drug called Lenacapavir works for preventing HIV in real-world settings. It will offer 3700 young people (aged 15-35) in Cape Town a choice between this new injection (given twice a year), another approved injection (g…

This study aims to find out if it's practical and acceptable to offer HIV prevention medication (PrEP) during routine visits at a family planning clinic. Researchers will ask about 83 patients and their doctors to try a new process for discussing and starting PrEP during regular …

This study is testing whether a text message program can encourage young adults in Uganda to get tested for HIV and use condoms more often. Researchers will enroll 750 people aged 18-22 and send them interactive texts with quizzes, badges, and advice. They will compare this group…

This study is testing a virtual health education program called LEARN 2. It aims to prevent heart and metabolic diseases in men living with HIV by teaching them about shared risk factors. Researchers will compare men using the weekly online program to a waitlist group to see if i…

This study is testing a new mobile app package designed to help HIV-negative men who have sex with men and use methamphetamine stay on their daily HIV prevention medication (PrEP). Researchers want to see if the app is easy to use and acceptable, and if it helps improve medicatio…

This study is testing a new program to help young people (ages 13-24) stay on their HIV prevention medication (PrEP). The program combines home or community delivery of PrEP services with a smartphone app for support. Researchers will compare this new approach to standard clinic …

This study aims to find the best methods to screen for tuberculosis (TB) and the safest time to give TB preventive medicine to pregnant women living with HIV in Uganda. It will compare different screening tests and whether to start preventive treatment during pregnancy or after b…

This study is testing a new 12-week online program designed for Latino men who have sex with men. The goal is to see if the program can help participants build skills to cope with social stigma, reduce their risk related to methamphetamine use, and make progress in starting and m…

This study tests a counseling program called Healthy Families-PrEP that helps women in rural Uganda use HIV prevention medication (PrEP) when they are trying to get pregnant, during pregnancy, and after giving birth. The goal is to reduce HIV infections in women and prevent passi…

This study aims to find better ways to help Black women get PrEP, a daily pill that prevents HIV infection. It will work with Planned Parenthood clinics in Illinois to test new support strategies for doctors and patients, focusing on women who have recently had a sexually transmi…

This study aims to see if making HIV and sexually transmitted infection (STI) testing and prevention medication (PrEP) navigation a standard, routine part of primary care visits increases how many people use these services. It will involve about 700 adults aged 18-45 at two healt…

This study aims to see if having young people (ages 15-24) trained to provide HIV prevention medication (PrEP) to their peers in community settings works better than the standard clinic-based care in Brazil. It will involve 1,400 young people who are at risk for HIV but not curre…

This study is testing a smartphone app designed to help men who have sex with men reduce risky drug use during sexual activity ('chemsex'), which is linked to higher HIV transmission. The app sends timely, personalized support messages when users might be most vulnerable to risky…

This study is testing a new digital support tool designed to help emergency room and urgent care patients start and stay on HIV prevention medication (PrEP). Researchers will first develop the tool by talking to patients and providers, then test it with 120 eligible patients in B…

This early-stage study is testing the safety of three lab-made antibodies designed to prevent HIV infection. Researchers will give these antibodies, alone and in combination, to 83 healthy adults without HIV to check for side effects and see how the body processes them. The goal …

This study is testing a new mobile app designed to help women recently released from jail or prison. The app aims to connect them more easily to services that prevent HIV infection and treat opioid addiction. Researchers will compare the app's effectiveness against standard suppo…

This study aims to see how well a long-acting, injectable HIV prevention medication works for adults who inject drugs and are at risk for HIV. About 100 participants will receive the injection every two months for seven months, along with support from a dedicated guide to help th…

This study is testing whether a smartphone app that provides personalized music can help people with HIV manage their chronic pain. 60 participants will be randomly assigned to either use the music app daily for 3 months or receive educational materials about pain. The main goal …

This study is testing two different phone-based programs to help older adults with HIV who have trouble sleeping. One program focuses on improving sleep habits, while the other teaches mindfulness techniques. Researchers want to see if either program can improve sleep quality and…

This study aims to see if one of two different medications works better to treat depression and mild memory problems in people living with HIV. Researchers will compare pramipexole, a drug that affects dopamine, to escitalopram, a common antidepressant. They will check how well t…

This study is testing whether metformin, a medication typically used for diabetes, can help treat depression in people living with HIV. Researchers will enroll 600 HIV-positive adults in Uganda who have depression but aren't currently taking antidepressants. The trial will compar…

This study aims to understand why women living with HIV in South Africa, who are at high risk for cervical cancer, sometimes miss important follow-up medical appointments after an abnormal Pap smear. Researchers will interview patients and healthcare providers to identify barrier…

This study aims to find the best way to help pediatric clinics offer more confidential HIV testing to their teenage patients. It will test two main ideas: training doctors on state laws and setting up new clinic protocols. The goal is to see if these changes make it easier and mo…

This study is testing a training program designed to reduce unconscious racial bias in pharmacists who prescribe PrEP, a daily pill that prevents HIV. The research will involve 70 pharmacy students and will measure whether the training is practical, acceptable, and can reduce bia…

This study is testing a new program designed to get more people tested for HIV when they visit emergency rooms in Kenya. It focuses on reaching groups that often miss regular testing, like men and young adults. Researchers will compare hospitals using the new program to those usi…

This study aims to create and test a training program to help doctors reduce discrimination against gay men and people living with HIV. It will involve 155 sexual health doctors in Vietnam. The researchers will use trained actors posing as patients to measure stigma before and af…

This study aims to understand if going through menopause increases the risk of heart disease for women living with HIV. Researchers will analyze existing health data and use MRI scans from 90 women to look at inflammation and body composition. The goal is to fill a key knowledge …

This study is testing a program called PEACHES 2.0, which aims to reduce stigma in healthcare clinics. The goal is to see if reducing stigma makes it easier for doctors to offer, and for patients to receive, important services like anal STI testing, HIV prevention medication, and…