HIV

This early-stage trial is testing whether experimental HIV vaccines can safely teach the immune system to recognize and fight the virus. Healthy adults without HIV will receive a protein nanoparticle vaccine, followed by a booster—either another protein nanoparticle or an mRNA va…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This study tests a program called Light Inside, designed to reduce stigma for women living with HIV who use drugs. The program involves five small-group sessions that teach coping skills and communication strategies to help participants stay engaged in HIV care and adhere to thei…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This study tests a peer navigation program for 250 people living with HIV who also use substances. The program assigns a trained peer to help participants stay connected to HIV care and substance use services. Researchers will measure viral suppression and clinic attendance to se…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study tests whether baricitinib, an FDA-approved drug for other conditions, can keep HIV under control after participants stop their usual antiretroviral therapy (ART). Twenty people with well-controlled HIV will take baricitinib alongside ART for 26 weeks, then continue bar…

This early-phase trial tests a digital program called CONNECT, designed to help women who have survived sex trafficking access care for HIV, substance use, and mental health. Delivered through a street medicine team that serves unhoused women, the program pairs participants with …

This study tests whether a program that helps incarcerated men with HIV notify their sex and drug-use partners about possible HIV exposure can increase testing and treatment. Participants can choose to tell partners themselves or have a trained notifier do it anonymously. The goa…

This study looks at whether the RSV vaccine given in late pregnancy can help protect babies born to mothers with HIV. RSV is a leading cause of infant hospitalization, and babies exposed to HIV are at higher risk. Researchers will measure antibody levels in mothers and infants to…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

This study tests whether offering rapid HIV testing during a dental visit leads more people to get tested than simply referring them to a lab. About 6,700 adult dental patients at four community health centers will be offered either a quick oral swab test on-site or a referral fo…

This study looks at whether people with HIV who need a liver transplant can safely receive a liver from a donor who also had HIV. Researchers will compare infections and cancer rates between those who get an HIV-positive donor liver and those who get an HIV-negative donor liver. …

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This study will test a Spanish-language program called Healthy Choices for 45 young adults (ages 18-29) living with HIV in the Dominican Republic who also struggle with alcohol use and stigma. The program is designed to help them better manage their health and reduce the impact o…

This study will compare two different HIV medication combinations in 60 people who also have active tuberculosis. Participants will receive either a newer drug (Ainuovirine) or a standard one (Efavirenz), along with their TB meds. The goal is to see which regimen better suppresse…

This study will test a mobile app called MindBodyU designed to help young people (ages 16-25) living with HIV in South Carolina stay connected to their care and take their HIV medication regularly. The goal is to see if the app is easy to use, liked by users, and helps improve me…

This study tests a program called Coach Mpilo, where trained peers (coaches) provide one-on-one support to men living with HIV. The goal is to help these men stay engaged in HIV care, take their medication regularly, and achieve viral suppression. The trial will enroll 800 men in…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study tests whether pharmacy technicians can help people with HIV get long-acting injectable medication more easily at community clinics in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to improve access to modern HIV tr…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This early-stage trial tests an experimental drug called JL18008 in HIV patients whose immune systems have not fully recovered despite standard antiretroviral therapy. The study will enroll 52 adults and give them a single injection of JL18008 or a placebo. Researchers will check…

This study explores whether letting people choose their own HIV support method helps them stay in care. 140 adults starting or restarting HIV treatment in Cape Town will be randomly assigned to standard care, in-person group support, or a choice of in-person, WhatsApp group, or a…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study tests whether daily text reminders, paired with small rewards like school supplies or sports items, can help adolescents (ages 15-19) with HIV take their antiretroviral medicine on time. 327 teens in Ethiopia will be split into three groups: two receiving different typ…

This study will test two ways to find TB in pregnant women with HIV: using symptoms or a blood test. It will also compare starting TB prevention medicine right away versus after giving birth. The goal is to reduce harm to mothers and babies. About 1,500 pregnant women in Uganda w…

This pilot study tests whether a peer-led program called Yuva Sath can help young people (ages 18-29) who inject drugs stay engaged in substance use treatment and HIV prevention. The program includes six one-on-one sessions with a peer counselor and weekly text check-ins. Researc…

This trial is testing whether the GeneXpert system, a portable device that can run multiple tests, can accurately detect HIV, chlamydia, gonorrhea, hepatitis C, and HPV in community health centers and clinics. Researchers will compare its results to standard lab tests and track w…

This study tests a special microscope that takes very clear, detailed pictures of cervical tissue right where the patient is being seen. The goal is to see if it can give doctors the same quality images as a standard lab test, but much faster. About 400 women in Mozambique and Br…

This pilot study tests whether training popular opinion leaders in rural South Africa can increase uptake of HIV prevention tools. Researchers will select and train young adults to share sexual health information and distribute HIV self-tests to their peers. The study will assess…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This study tests a mobile health program called PrEP Choice to help young people ages 13-24 start and stick with HIV prevention pills or shots. It also looks at whether taking the antibiotic doxycycline after sex (DoxyPEP) can prevent other sexually transmitted infections. About …

This study tests a new way to help young people (ages 13-24) stick with PrEP, a medication that prevents HIV. Participants get PrEP delivered to a community spot (like home or a mobile van) and use a smartphone app for reminders and support. The goal is to see if this combo impro…

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This study tests a training package called YACHT in 42 HIV testing clinics across Florida. The training helps staff use motivational interviewing to improve HIV testing and PrEP referrals for young men who have sex with men. Researchers will track whether testing rates and servic…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study adapts a program called CARES to help 2,100 adolescent girls and young women (ages 16-24) in South Africa and Zimbabwe consistently use HIV prevention methods like pills, rings, or injections. The program includes counseling, text reminders, and peer support. Researche…

This study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked …

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…

This study aims to help 400 male commercial minibus drivers in Nigeria use HIV self-testing and long-acting injectable medications for both HIV treatment and prevention. Drivers will be trained as peer educators to promote these tools among their community. The goal is to make it…

This study tests whether adding a remote nurse via telehealth to pharmacy-based PrEP/PEP services helps more people start and continue HIV prevention. About 1,580 pharmacy clients in Kenya will either get standard pharmacy care or extra telehealth support with SMS reminders. The …

This study will test a mobile app called HealthMPowerment designed to help Black adolescents and young adults in Alabama take PrEP, a daily pill that prevents HIV. Ten teens and their adult supporters will use the app for a few weeks, and researchers will check if it's easy and a…

This study tests a digital teleconsultation program called E-PrevenT to help transgender sex workers and their clients access HIV and STI prevention services. The program aims to reach people who are often left out of traditional prevention efforts. Researchers will enroll 250 pa…

This study tests a counseling program called Healthy Families PrEP for HIV-negative women in rural Uganda who are planning pregnancy or recently gave birth. The program provides information and support to help women take daily PrEP pills to prevent HIV. Researchers will enroll 66…

This study tests whether having trained peer workers deliver HIV prevention medication (PrEP) in community settings helps more young people in Brazil start and stay on PrEP compared to standard clinic care. About 1,400 youth aged 15-24 who are sexually active and not currently us…

This study tests whether making HIV and STI testing and PrEP navigation a routine, opt-out part of primary care increases their use. About 700 adults aged 18-45 at health centers in Mississippi will take part. Researchers will compare a standard-care period to an integrated-care …

This study will offer young people aged 15-35 in Cape Town a choice of HIV prevention methods: a new twice-yearly injection (lenacapavir), a two-monthly injection (cabotegravir), or daily pills. Researchers want to see which option people stick with over 18 months and how best to…

This study tests whether a text-message program can help 18-22 year-olds in Uganda prevent HIV. Participants receive texts with quizzes, badges, and advice to encourage HIV testing and condom use. The goal is to see if these messages make a difference over 12 months compared to n…

This study looks at ways to help Black women get PrEP, a daily pill that prevents HIV. Researchers will try special strategies at family planning clinics to see if more women start and stay on PrEP. About 250 women with a recent STI will take part.

This study tests a new tool to help people in emergency departments and urgent care start and continue taking PrEP, a daily pill that prevents HIV. About 120 people who are eligible for PrEP will use the tool, which is designed to address their medical and social needs. The goal …

This study tests two smartphone tools to help HIV-negative men who have sex with men take their daily HIV prevention pill (PrEP) regularly and reduce methamphetamine use. One hundred men with mild to moderate meth use disorder will use the apps for 6 months. Researchers will chec…

This study tests whether watching storytelling videos and writing or talking about personal experiences can reduce stigma and improve quality of life for women living with both cervical cancer and HIV in Zambia. Participants are randomly assigned to different combinations of stor…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study tests a quality improvement method called SAIA to help emergency departments in Kenya offer more HIV tests to people who often miss out, like men, teens, and key populations. Researchers will compare hospitals that use SAIA with those that don't, measuring how many pat…

This pilot study will test a series of brief, private text messages sent via WhatsApp or Telegram to help people who use drugs in Kazakhstan feel more comfortable seeking PrEP, an HIV prevention pill. The messages address stigma, confidentiality worries, and misinformation. Forty…

This study tests whether a low-cost visual aid called B-OK bottles can help people in South Africa better understand HIV and antiretroviral therapy (ART). The bottles use beads to show how HIV affects health and how ART can make the virus undetectable and untransmittable. About 6…

This study brings together data from multiple previous trials to investigate a rare group of people with HIV who can keep the virus under control even after stopping antiretroviral therapy. Researchers will analyze stored blood samples and clinical records to look for biological …

This study tests whether a video app that explains 'Undetectable = Untransmittable' (U=U) can help people with HIV stay on treatment and keep the virus under control. About 880 people from clinics in South Africa will use the app during counseling. The goal is to see if better un…

This study looks at whether hairdressers in the East of England can become sexual health champions for Black African women. The goal is to see if it's possible and acceptable for hairdressers to share information about HIV prevention and local sexual health services with their cl…

This study tests whether training healthcare providers to reduce stigma can increase the use of HIV and STI prevention services, like testing and preventive medications. It will involve 8 clinics in the Mississippi Delta and track changes in how often patients receive these servi…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to find more people with undiagnosed HIV or subs…

This study tests whether a pop-up alert in electronic medical records can help primary care doctors order screening for HIV, hepatitis B, and hepatitis C all at once. About 50 primary care providers will participate, and their patient visits will be randomly assigned to either se…

This study will enroll 1,260 pregnant women in Botswana, Kenya, and Zimbabwe to test a package of support that includes problem-solving sessions, infant feeding advice, and play groups. The goal is to see if these interventions improve child development and growth by age 2. Resea…

This study tests a 12-week group program for HIV-negative Latino men who have sex with men and use methamphetamine. The program aims to help them cope with stigma, build resilience, and reduce meth use while also improving their interest in and use of PrEP, a medication that prev…

This study tests whether a multi-day training program can reduce stigma that doctors in Vietnam show toward people with HIV and men who have sex with men. Researchers will send trained actors ("standardized patients") to clinics to pose as real patients and measure how doctors tr…

This study looks at whether making it easier for teens to have private, confidential talks with their doctor can increase HIV testing. Researchers will work with 4 pediatric clinics to see if this approach is practical and well-liked by staff. The goal is to learn how to make HIV…

This study tests a questionnaire called POSITIVE OUTCOMES to help doctors focus on what matters to people living with HIV, like mental health and social concerns. About 17,000 adults from five clinics in the UK and US will try it out. The goal is to see if using this tool improve…

This study tests whether a one-hour online training video can reduce unconscious racial bias among pharmacy interns who prescribe HIV prevention medication (PrEP). Researchers will recruit 70 pharmacy interns in Boston to watch the video and then measure changes in bias using a s…