Can your nose predict brain health? new study tests smell and choices in HIV and addiction

NCT ID NCT07637669

Not yet recruiting Knowledge-focused Sponsor: National Institute on Drug Abuse (NIDA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 34 times

Summary

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, and some may have a brain scan. The goal is to understand how these conditions impact brain function, not to provide treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how HIV and substance use affect the brain, potentially pointing to new ways to detect or treat thinking problems.
What could go wrong: This is an observational study, not a treatment trial. It will not directly improve health, and results may not apply to everyone with HIV or substance use disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Anosmia HIV infectious disease substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV SUBSTANCE USE DISORDER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

National Institute on Drug Abuse

Baltimore, Maryland, 21224, United States

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