Which flu vaccine packs a bigger punch for people with HIV?

NCT ID NCT07644546

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked after 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
MF59-adjuvanted influenza vaccine and high-dose influenza vaccine
What this could lead to
If this trial succeeds, it could show which flu vaccine works best for people with HIV, leading to better protection during flu season.
What could go wrong
This trial hasn't started yet and is relatively small (350 people). Results may not apply to all people with HIV, and the vaccines may not prevent infection entirely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

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