HIV

This early-stage study is testing a new cell therapy called CAR-T to see if it can achieve a functional cure for HIV. Researchers are enrolling a small number of HIV-positive adults whose virus is well-controlled with medication. The main goals are to check if the treatment is sa…

This is an early-stage study to test the safety and immune response of a new HIV vaccine candidate. It will enroll 120 healthy adults in Southern Africa, including people living with HIV who have their virus well-controlled with medication. The main goal is to see if the vaccine …

This is a very early study to test the safety and immune response of a new two-part HIV vaccine regimen in healthy adults. The study involves giving a 'prime' shot followed by 'boost' shots to try to train the immune system to fight HIV. Researchers will closely monitor 42 partic…

This study is testing an 8-week exercise and education program designed to help people living with HIV improve their heart health. The program combines supervised gym sessions with home workouts and coaching to help participants become more physically active. Researchers want to …

This study is testing whether a city-run housing support program helps people with HIV manage their health better. The program provides rent help and counseling to people who are homeless or struggling to keep housing. Researchers will compare health and life outcomes for 200 peo…

This study is testing whether a simpler, two-drug HIV treatment works well for transgender women who already have their virus under control with standard three-drug therapy. Researchers will switch 50 participants to the two-drug combination and follow them for 48 weeks to see if…

This study aims to help people living with HIV quit smoking by offering them different nicotine replacement options like e-cigarettes, nicotine pouches, or patches. Researchers want to see which approach works best to help participants stop smoking tobacco cigarettes for at least…

This study aims to develop and test support strategies to help people in Zimbabwe who have both HIV and cancer stay engaged in their HIV care while undergoing cancer treatment. Researchers will first observe 150 patients to identify barriers, then create support strategies with e…

This study is testing a new combination of drugs designed to prevent a dangerous complication called graft-versus-host disease (GVHD) after a bone marrow transplant. The goal is to see if this approach is safe and effective for people living with HIV who have blood cancers that c…

This study is testing if adding an old HIV drug, efavirenz, to a person's current treatment can kill cells that are still producing small amounts of HIV. It focuses on people whose virus levels are very low but still detectable despite excellent treatment adherence. The goal is t…

This study is testing a new support program to help young LGBTQ+ people living with HIV in Brazil take their daily medication more consistently. The program combines group counseling sessions with daily text message reminders. Researchers want to see if this approach helps partic…

This small pilot study is testing whether a combination of an existing medication and counseling from a pharmacist is a practical and acceptable way to help people with HIV reduce their alcohol use. The 12-week program is being offered to 30 veterans in Atlanta who have HIV and d…

This study is testing whether a non-invasive brain stimulation technique called TMS can help reduce cravings for methamphetamine in people living with HIV. Researchers will compare two different stimulation patterns against a fake (sham) treatment to see which is better at loweri…

This study is testing two remote support programs to help older adults with HIV who live in rural Southern US communities. Researchers want to see if online peer support groups and personalized case management can help people stick to their medication, keep their virus under cont…

This study is testing whether brief phone counseling from pharmacists can help people with HIV who drink alcohol and take multiple medications reduce their risk of falls and thinking problems. The program involves medication reviews, personalized risk discussions, and home alcoho…

This study aims to find the safest and most effective dose of the HIV medication doravirine for pregnant women in South Africa. Researchers will compare the standard HIV treatment to a new combination that includes doravirine, tracking how the drug moves through the body during p…

This study is testing a virtual counseling program called MATTER. It aims to help people living with both HIV and a drug addiction by addressing feelings of shame and stigma that can make it hard to stay in medical care. The program teaches coping skills and provides resource sup…

This study is testing a new support package designed to help people living with HIV in Malawi stay on their medication when they need to travel. It will involve 400 people who are starting or restarting treatment. The program includes special counseling, a support hotline, and tr…

This study tests two brief counseling approaches to help people with HIV who have alcohol use disorders maintain abstinence or low-risk drinking after periods of heavier use. Researchers will compare a computer-delivered program, a counselor-delivered program, and standard clinic…

This pilot study is testing whether a combination of medication and counseling is practical, acceptable, and helpful for reducing alcohol use in people living with HIV. The 12-week program involves an existing medication (used 'off-label' for alcohol) along with support from a cl…

This is a small pilot study to see if a new support program is practical and acceptable for people living with HIV who also use substances. The program aims to help participants stick to their HIV medication, manage substance use, and stay engaged with their healthcare. Researche…

This study is testing a new step-by-step guide and digital tool to help health workers at local clinics and hospitals in Mozambique and Zambia better identify and treat tuberculosis (TB) in children. It aims to see if this tool helps find more TB cases and leads to faster, more a…

This Oxford University study is testing whether a combination of HIV vaccines and long-acting antibody infusions can help people with HIV control the virus without needing daily medication. The trial will involve 48 participants to see if this approach can train the immune system…

This study is testing if giving monthly cash payments to pregnant women with HIV in Botswana helps them manage their health better. It aims to see if the money reduces stress, helps them take their HIV medication consistently, and keeps them in medical care after giving birth. Th…

This study is testing whether using medical drones to deliver HIV medication improves health outcomes for people living in remote island communities in Uganda. Researchers will compare drone delivery to the standard method of boat delivery or clinic pickup to see if drones help m…

This study is testing whether an automated text messaging program can help people living with HIV in Cambodia quit smoking. It will enroll 800 adult smokers with HIV who are willing to try to quit. Researchers will check if participants have quit by asking them and using a breath…

This study is testing a systems improvement strategy to better integrate HIV services into family planning clinics in Kenya. It aims to increase HIV counseling, testing, linkage to care, and access to prevention medication (PrEP), especially for adolescent girls and young women. …

This study is testing if a medication called tirzepatide, which is approved for weight loss and diabetes, can also help reduce chronic inflammation in people living with HIV who are overweight or obese. It will involve 12 adults with well-controlled HIV who will receive weekly in…

This study is testing three different approaches to help older adults living with HIV become more physically active. Researchers will compare physical activity coaching, therapy to address common barriers like pain or low motivation, and a social support program using Fitbit devi…

This study is testing a counseling program designed to help young people reduce their stimulant drug use and lower their risk of getting or spreading HIV. It will involve 360 participants aged 16-24 who report having condomless sex while using stimulants. The program includes 10 …

This study is testing whether having trained peers provide education and counseling helps people in Uganda complete their tuberculosis (TB) treatment and stay on their HIV medication. It will involve about 1,920 adults who are starting TB treatment, some of whom also have HIV. Th…

This study aims to improve health for women living with HIV by making cervical cancer screening and treatment a standard part of their existing HIV care. It will test two different sets of support strategies in Nigeria to see which one works better to get more women screened and …

This large clinical trial aims to find better treatments for cryptococcal meningitis, a severe and often fatal brain infection that primarily affects people living with HIV. It will test multiple new or improved antifungal drug combinations in up to 2000 participants, comparing t…

This study aims to help HIV clinics reduce stigma that can prevent people from getting and staying in care. Five clinics in the southern and eastern US will work with researchers to create and test staff training programs focused on respectful policies and attitudes. The goal is …

This study aims to find the most effective way to deliver smoking cessation support to people living with HIV. Researchers are comparing a new, proactive outreach program that contacts patients directly with the standard clinic-based approach. The goal is to help more people quit…

This study aims to understand how not having reliable access to enough food affects the health of people living with HIV, especially their risk for diabetes and heart problems. It will test a support program that uses trained peer guides and mobile phone tools to help participant…

This study is testing a new flexible support program called CHOICE for people in Malawi living with HIV who have stopped taking their medication. The program lets participants choose how and where they receive support services over time, based on their changing needs. Researchers…

This study is testing if a pill called pregnenolone can help reduce depression in people living with HIV. About 120 participants will take either pregnenolone or a placebo (sugar pill) for 8 weeks while staying on their current depression medications. Researchers will use brain s…

This study is testing whether a program led by experienced local mothers can help pregnant women in South Africa reduce alcohol use and stick to their HIV prevention or treatment medications. The program involves one-on-one supportive conversations with trained 'mentor mothers' w…

This study is testing if a simpler, two-drug HIV treatment works as well as the standard three-drug treatment for people who are also taking medicine for tuberculosis (TB). It will enroll 150 adults with both HIV and TB who are starting HIV treatment for the first time. The goal …

This study aims to make prison needle exchange programs work better in nine Canadian federal prisons. It focuses on helping people who inject drugs in prison access clean needles to prevent the spread of HIV and hepatitis C. Researchers will test different support strategies over…

This study is testing if providing free legal help for problems like housing and employment can help people recently released from jail stay in HIV care and improve their health. It will train healthcare and legal teams to work together and enroll 100 people living with HIV who h…

This study is testing a new, more flexible strategy to help people living with HIV who smoke. Instead of focusing only on quitting completely, it also helps participants reduce smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to lower …

This study is investigating whether problems with the vagus nerve contribute to gut issues and inflammation in people living with HIV. Researchers will test if a medication called pyridostigmine or gentle nerve stimulation can help. The goal is to find new ways to manage these co…

This small pilot study is testing whether a medication not officially approved for alcohol problems, combined with counseling from a pharmacist, can help people living with HIV reduce their drinking. The goal is to see if this approach is practical, safe, and acceptable to patien…

This study is testing two support programs to help people who have been involved with the justice system access HIV care, prevention services like PrEP, and employment. Researchers want to see if adding an employment navigator and small financial incentives to a basic health navi…

This study aims to find the safest and most effective malaria treatments for children, especially those also living with HIV. Researchers in Uganda will follow 380 children for two years, comparing two common malaria drugs and checking how they interact with HIV medication. The g…

This study is testing if the medication gabapentin can help people with HIV who drink heavily. The goal is to see if it helps them achieve an undetectable HIV level and drink less alcohol. About 220 participants will be randomly assigned to receive either gabapentin or a placebo …

This study is testing a counseling program designed to help Black women who are living with HIV and have experienced trauma. The goal is to see if this program helps them take their HIV medication more consistently and improves their mental health. Researchers will measure change…

This is an early study to test a new injectable drug called LP-98 in people recently diagnosed with HIV who have not yet started standard antiviral therapy. It will enroll 30 participants to receive one of three different doses, given as four shots over two months. The main goals…

This study is testing whether starting HIV medication very quickly after diagnosis can help reduce the stigma felt by people who inject drugs. It will involve 135 participants, including people from the general community and those in prison. The goal is to see if this faster trea…

This study is testing whether adding alcohol reduction counseling to regular TB and HIV medical care can help patients drink less and improve their health. Researchers will work with 450 adults in India who have tuberculosis, HIV, or both, and who report unhealthy drinking. Parti…

This study is developing and testing a new program called 'One Mind One Heart' that combines mindfulness training with behavior change support delivered through text messages. It aims to help older adults with HIV (age 50+) who are experiencing psychological distress reduce their…

This study is testing a more flexible way to provide HIV care for people who struggle to keep regular clinic appointments. It offers drop-in visits and mobile care to 400 participants in California who face barriers like homelessness or substance use. The goal is to see if this a…

This study aims to see if training traditional healers to offer HIV testing can help more people in rural South Africa learn their status. It will compare areas where healers provide testing and support to areas with standard testing options only. The goal is to reach people who …

This study is evaluating a new point-of-care medical device called MagIA H3S. The device is designed to screen for four major infections—HIV, hepatitis B, hepatitis C, and syphilis—from a single blood sample. Researchers in Ivory Coast and Kenya will test its accuracy compared to…

This study aims to see if creating special HIV teams in hospitals can help find more people who have HIV but don't know it. The teams will work in hospitals across ten European countries, checking patient records for signs that might suggest HIV and encouraging doctors to offer t…

This study aims to find the most effective way to screen women with HIV for cervical cancer in Cameroon. It compares a mobile team that brings screening to local clinics against the standard method of sending women to a central hospital. The goal is to see which approach helps mo…

This study aims to understand how well HIV prevention pills (PrEP) work in everyday life across Italy. It will follow 5,000 adults who are HIV-negative and using PrEP to see how many new HIV infections occur, monitor side effects, and identify what helps or hinders people from st…

This study is testing whether three different lab-made antibodies, given together by IV infusion, are safe and can help prevent HIV infection in people who are HIV-negative. It will enroll 200 healthy adults to receive the antibodies or a placebo and follow them for 18 months. Th…

This study aims to see if adding testing for common sexually transmitted infections (STIs) to standard HIV prevention screening helps more young women in Africa start and continue taking PrEP, a daily pill that prevents HIV. About 4,500 women in Uganda will be randomly assigned t…

This study is testing a community program designed to help more Black men in Prince George's County, Maryland, start taking medication to prevent HIV. The program uses peer-led events to reduce stigma and build social support. Researchers will compare participants in the program …

This study is looking at whether it's practical and acceptable for local pharmacies to manage and give a long-acting HIV prevention injection called lenacapavir. It will involve about 75 HIV-negative adults who want to start or switch to this prevention method. The main goal is t…

This study aims to find a better way to screen for and prevent cervical cancer in women living with HIV in Cameroon. It will test a simpler, 'single-visit' approach where testing and any needed treatment happen in one appointment, hoping to reduce the number of women who drop out…

This study is testing a new program to prevent HIV infections among people in the Dallas County Jail. A navigator will meet with interested individuals to discuss their HIV risk, offer testing, and provide education about PrEP, a daily pill that prevents HIV. The goal is to succe…

This study aims to find the best low-cost methods to encourage people at higher risk for HIV to get tested again every few months. It will test up to 12 different strategies, like text message reminders, on 30,000-40,000 adults in rural Kenya and Uganda. The main goal is to see w…

This study is testing a new community program designed to help Latinx men at risk for HIV start and consistently take prevention medication (PrEP). It combines easy-access pharmacy services with a social support network. The goal is to see if this approach is more effective than …

This study is testing a new program called 'Prevention Ambassadors' that works through syringe service programs. It trains people who use drugs to give HIV self-test kits and service information to their friends who also use drugs. The goal is to see if this peer-led approach mak…

This study aims to understand if people at risk for HIV in Thailand would prefer a new, long-acting injectable prevention drug over daily pills. Researchers will survey over 10,000 men who have sex with men and transgender women about their preferences for different prevention op…

This study is testing a program that distributes a new type of syringe designed to reduce the spread of HIV and hepatitis among people who inject drugs. It will run in nine low- and middle-income countries, gathering feedback from drug users and measuring infection rates. The goa…

This study is testing a new system called the JUNTOS Referral Network. It aims to help HIV test counselors better connect Latino men who have sex with men to important prevention services like PrEP and HIV treatment. The goal is to see if this network improves how many men get re…

This study aims to find the best way to help men who have sex with men and use methamphetamine start taking medication to prevent HIV. Researchers will test two different telehealth counseling approaches with 400 participants over 12 months. The main goal is to see which method h…

This study is testing if a text message program can encourage more teenagers to get tested for HIV. Researchers will enroll 360 adolescents (ages 13-19) across the US and randomly assign them to receive either the special text messages or general health information. The main goal…

This study is testing if a series of community plays can reduce stigma and increase support for young women using HIV prevention medication (PrEP) in Kenya. Researchers will perform six plays for local audiences and measure if people's attitudes change. The goal is to see if this…

This study is testing two different counseling programs to help women who use drugs in Tanzania start and continue taking a daily pill that prevents HIV infection. Researchers will enroll 200 women and randomly assign them to receive either basic counseling about the prevention p…

This study is testing a counseling program designed to help male couples where one partner has HIV and the other does not. The program focuses on improving their relationship to reduce stigma, improve mental well-being, and support healthy behaviors. Researchers will compare the …

This study is testing whether an AI-powered chatbot can effectively deliver a proven therapy to help prevent suicide. It will involve 50 older adults living with HIV who are at risk for suicide. The goal is to see if this accessible, digital approach helps people better manage di…

This study is testing a 12-week program designed to help women over 40 who are living with both HIV and high blood pressure. The program combines personalized exercise plans, support from a peer, and home blood pressure monitoring. Researchers want to see if this approach is prac…

This study is testing whether a special counseling program can help reduce suicidal thoughts and improve HIV care for teenagers living with HIV in Malawi. Researchers will enroll 60 depressed teens who have had suicidal thoughts and randomly assign them to receive either the new …

This study is testing if taking Tai Chi classes online can help reduce feelings of depression in older adults living with HIV. Researchers will compare a 12-week online Tai Chi program to online health education classes to see which is better at improving mood. They are recruitin…

This study is testing two different phone-based programs to see which one better helps people with HIV who also have chronic pain and insomnia. One program focuses on building better sleep habits, while the other teaches mindfulness techniques. Researchers want to see if these pr…

This study is testing whether group counseling can help people who feel shame or stigma because of their health condition. Researchers are enrolling 195 adults with conditions like obesity, cancer, HIV, diabetes, or chronic pain who report feeling stigmatized. Participants will t…

This study is exploring whether providing pasteurized donor human milk to infants born to mothers with HIV is a practical feeding option. Researchers will give donor milk to 10 families in Saskatchewan for 6-8 weeks and track how often it's used and any challenges. The goal is to…

This study aims to create a long-term database to understand and improve HIV care in Washington, DC. It will follow up to 19,000 people who are either living with HIV or are at higher risk for getting it. Researchers will collect health information from participating clinics over…

This study is testing if giving low-income Black men living with HIV a monthly cash payment of $500 for six months helps them get to more doctor's appointments and take their HIV medication more consistently. Researchers want to see if this extra money reduces barriers to care an…

This study monitors adults with HIV in the Washington, D.C. area to understand long-term health outcomes and how the immune system responds to standard treatments. Participants visit every few months for check-ups and blood tests that support ongoing research and train new infect…

This study aims to understand why a serious parasitic disease called visceral leishmaniasis (VL) often returns or persists in patients who also have HIV. Researchers will follow 20 adult patients in Ethiopia to learn what factors in the patient's body and the parasite cause this …

This study is testing a new data dashboard designed to help clinics in Alabama better track and improve their HIV prevention services. It will collect real-time information from seven clinics to identify where services are lacking and to help ensure PrEP, a preventive medication,…

This study aims to understand how HIV affects different parts of the body by comparing virus levels in blood versus lymph nodes and bone marrow. Researchers will enroll 400 people, including those with and without HIV, and collect blood and lymph node tissue samples. The goal is …

This study aims to better understand how HIV infection works by collecting blood samples from people with and without HIV. Researchers will analyze these samples in the lab to learn how the virus interacts with the immune system and causes disease. The study does not test treatme…

This study aims to understand the real-world experience of providing and receiving long-acting HIV injections for people who live far from their main HIV clinic. Researchers will work with about 55 patients and clinic staff in Nebraska and Iowa to identify the main barriers—like …

This study aims to understand how a small group of people with HIV, called 'long-term nonprogressors,' can control the virus for years without medication. Researchers will collect blood samples from 400 participants, including these rare controllers, people with typical HIV progr…

This study aims to understand how different ways of delivering HIV treatment work in South Africa by analyzing existing medical records. Researchers will look at data from about 7 million people to see which care models help patients stay on treatment and achieve good health outc…

This study aims to understand the challenges of aging for people 50 and older who are living with HIV. Researchers will screen 100 participants for signs of frailty and offer a personalized activity and nutrition plan to some. The main goal is to learn more about aging with HIV t…

This study aims to understand why people living with HIV have a higher risk of heart attacks. Researchers will use MRI scans to measure fat stored around the heart and liver in 100 participants, comparing those with HIV to those without. The goal is to learn how this internal fat…

This study aims to create better prediction tools for liver disease in people living with HIV. Researchers will follow 320 HIV-positive participants for 5 years to understand how fatty liver disease and liver scarring develop and progress. The goal is to build models that can ide…

This study aims to understand how different ways of delivering HIV treatment are working in Zambia by analyzing existing medical records. It will look at data from about 1.2 million people living with HIV to see which care models are most used, who qualifies for them, and how the…

This small pilot study is testing whether a telemedicine support program is practical and helpful for people in Alabama who are living with HIV and also dealing with opioid or stimulant addiction. The goal is to see if remote healthcare visits can help connect this group to neede…

This study tracks the health and treatment of over 30,000 people living with HIV across France. Researchers are collecting routine medical information to understand how care is delivered, how well treatments work, and how health changes over time. The goal is to improve the quali…

This study aims to understand why older adults living with HIV often experience more muscle fatigue and difficulty exercising than their peers without HIV. Researchers will use leg muscle scans and blood tests to compare 200 participants aged 60+ with and without HIV. The goal is…

This study aims to understand how the immune system responds in people with HIV, especially when treatment is started early. Researchers will collect white blood cells from up to 750 HIV-positive adults who are not yet on medication, using a special blood filtering process. The g…

This study aims to understand the quality of life and care experience of pregnant women living with HIV in Paris, France. Researchers will survey 100 women at different stages—during pregnancy and after birth—to learn about their mental well-being, satisfaction with care, and cha…

This large study aims to find out if people who have tuberculosis (TB) but show no symptoms can still pass the disease to others. Researchers will follow over 6,700 people with HIV and their close contacts in Mozambique for a year, using advanced genetic testing to track how the …

This study aims to collect information about the stomach and esophagus health of people living with HIV. Researchers will follow 2,500 adults with HIV who are having their first upper endoscopy procedure. The goal is to better understand what gastrointestinal issues are common in…

This study analyzes existing medical records from 1 million HIV patients in Malawi to understand how different care delivery models work. Researchers will examine which treatment approaches clinics use, how many patients participate, and what health outcomes result. The goal is t…

This study aims to understand how Kaposi sarcoma (KS), a cancer often linked to HIV, behaves over many years. Researchers will observe 150 adults with KS, tracking their health through regular exams, scans, and tissue samples for up to 10 years. The goal is to learn why the disea…

This study is collecting blood, bone marrow, and tissue samples from people with HIV or certain virus-related cancers. The goal is to help researchers better understand how these diseases work, which could lead to future treatments. Participants will provide samples but will not …

This study aims to understand how HIV behaves in different body tissues, not just the blood. Researchers will collect small tissue samples from the tonsils, lymph nodes, intestines, and lungs of HIV-positive patients, patients with a rare immune condition (ICL), and healthy volun…

This study aims to better understand where and how HIV hides in the body when people are on effective treatment. Researchers will compare two groups of adults with well-controlled HIV: one stays on their regular medication, while the other pauses it for up to 90 days. Using speci…

This study collects blood samples from healthy volunteers and people with HIV to support laboratory research on infectious diseases and immune function. Participants undergo a special blood collection procedure called apheresis, which allows researchers to obtain larger quantitie…