Marijuana and HIV drugs: a risky mix or safe combo?

NCT ID NCT04800159

Ongoing Knowledge-focused Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how cannabis (marijuana) affects the levels of HIV medications in the blood and brain, as well as mood and thinking. Researchers will give cannabis or a placebo to 40 people with HIV to see if it changes how their drugs work. The goal is to understand if cannabis use is safe for people on HIV treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabis (THC and CBD)
What this could lead to: If successful, this study could help doctors understand whether cannabis is safe to use with HIV medications and how it might affect treatment.
What could go wrong: This is a small, early-stage study (Phase 2) with only 40 people receiving cannabis. Results may not apply to everyone, and the study looks at drug levels, not long-term health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS USE HIV

Contacts and locations

Locations

Ucsd Hnrp-Cmcr

San Diego, California, 92103, United States

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