ARTERIAL STIFFNESS

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The g…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This study tests whether empagliflozin, a drug currently used for diabetes, can reverse the natural stiffening of arteries that happens with age. Researchers will give 80 healthy adults aged 60-80 either the drug or a placebo daily for 12 weeks. The main goal is to see if artery …

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can prevent heart damage caused by a common type of chemotherapy (anthracyclines) in breast cancer patients. One hundred women will receive either dapagliflozin or a placebo daily during their che…

This study looks at whether a 12-week upper arm aerobic exercise program can reduce arterial stiffness in women who have had breast cancer. Arterial stiffness is a side effect of some cancer treatments and can increase heart risk. The trial will measure changes in blood vessel fl…

This study tests whether taking vitamin K2 supplements daily for 6 months can reduce the number of migraine days in adults with episodic migraine. Researchers will also measure if it improves artery stiffness, which is often higher in people with migraines. 160 participants will …

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study looks at how a type of fat in the blood called lipoprotein(a), or Lp(a), affects the stiffness of arteries, the health of blood vessel linings, and the heart's ability to pump. Researchers will follow 300 adults for one year, measuring these factors and tracking heart …

This study observes 80 transgender individuals starting cross-sex hormone therapy (testosterone or estrogen) to see how it changes eating behavior, metabolism, weight, and heart health. Participants are followed over time with no extra treatments or procedures. The goal is to und…

This study looks at how blood pressure and artery stiffness change over 24 hours in people at increased risk for heart disease, especially those with kidney problems. Researchers will monitor 120 participants using a wearable device and collect blood and urine samples. The goal i…

This study follows 7,500 adults who were part of an earlier health study. Researchers will use high-precision ultrasound to measure changes in artery stiffness and thickness over 12 to 16 years. The goal is to understand how arteries age and whether those changes can predict futu…