Hormone Therapy's hidden effects: new study eyes metabolism and heart risks

NCT ID NCT04838249

Recruiting now Knowledge-focused Sponsor: University of Leipzig Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study observes 80 transgender individuals starting cross-sex hormone therapy (testosterone or estrogen) to see how it changes eating behavior, metabolism, weight, and heart health. Participants are followed over time with no extra treatments or procedures. The goal is to understand how sex hormones influence the body, which could help prevent obesity, diabetes, and heart disease in this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: testosterone and estradiol/antiandrogens
What this could lead to: If successful, this study could reveal how sex hormones influence weight, metabolism, and heart disease risk, potentially improving long-term care for transgender individuals.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not apply to all populations, and the small size (80 participants) limits generalizability.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Feeding Behavior Obesity obesity disorder thrombotic microangiopathy Transsexualism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADIPOSITY ARTERIAL STIFFNESS EATING BEHAVIOR MICROANGIOPATHY TRANSGENDERISM TRANSSEXUALISM

Contacts and locations

Locations

Helmholtz Institute for Metabolic, Obesity and Vascular Research
RECRUITING

Leipzig, Saxony, 04103, Germany

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