NIH launches massive effort to unlock secrets of rare vascular diseases

NCT ID NCT02543996

Recruiting now Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 10 times

Summary

This study aims to collect blood and tissue samples from up to 10,000 people with rare genetic vascular or cardiovascular diseases, as well as their healthy relatives. Researchers will use these samples to identify genetic causes and understand how these diseases work. The goal is to lay the groundwork for future treatments, not to test any specific therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could uncover genetic causes of rare vascular diseases, pointing toward future treatments.
What could go wrong: This is an observational sample-collection study, not a treatment trial. It may not directly lead to therapies, and results could take many years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Rare Diseases Undiagnosed Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE UNDIAGNOSED DISEASES

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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