CARDIOVASCULAR DISEASE

This study tested whether a low dose of the blood thinner rivaroxaban could reduce the risk of major heart problems (like heart attack or stroke) in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to recei…

This early-stage study tested a new medicine called AMG 890 in 79 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. The goal was to check the drug's safety and how the body processes it. Participants received a single dose of the drug or a placeb…

This study tested a new drug called olpasiran in 281 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. Participants received either the drug or a placebo as a shot. The main goal was to see if olpasiran could safely lower Lp(a) levels over severa…

This study tested whether a smartphone app and regular phone calls could help people with heart disease complete their cardiac rehabilitation at home. 258 veterans took part. The goal was to see if this remote program improved exercise ability, symptom monitoring, and reduced hos…

This study looked at whether taking a probiotic supplement can improve blood vessel function and reduce inflammation in people with heart disease or type 2 diabetes. Researchers measured blood markers, gut bacteria, and vessel health in 215 adults. The goal was to see if changing…

This study tested a nurse-led program to help veterans with HIV better manage their blood pressure and reduce their risk of heart disease. About 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to support healthy changes…

This early-phase study tested whether injecting donor stem cells into the leg before amputation could prevent wound complications and reduce the need for further surgery. 81 adults aged 40-90 with severe leg artery disease received the injections. The main goal was to check safet…

This study looked at whether tildrakizumab, a drug already approved for psoriasis, can improve blood flow to the heart in people with moderate-to-severe psoriasis. 36 adults received the drug for 6 months, and researchers measured changes in coronary flow reserve using heart scan…

This large study aimed to find out if taking daily cocoa extract or a standard multivitamin could help prevent heart disease and cancer in older adults. Over 21,000 men aged 60+ and women aged 65+ were randomly assigned to take either the real supplements or look-alike placebo pi…

This study tested a 9-week internet-based therapy program designed to reduce stress, anxiety, and depression in people with heart disease. 215 adults with stable heart conditions and mild to moderate psychological distress took part. The program was personalized and guided by a t…

This study checked if newer psoriasis medications (IL17/23 inhibitors) can also improve heart health by measuring artery stiffness. Researchers followed 66 adults with moderate-to-severe psoriasis for one year, comparing those on the new drugs to those on standard treatments. The…

This study looked at whether eating whole eggs (with cholesterol) helps people aged 50-69 gain more muscle from resistance training compared to eating only egg whites. Participants did strength exercises and ate either whole eggs or egg whites. Researchers measured muscle gain, b…

This study looked at 50,000 living kidney donors in Canada to see if they have a higher risk of heart problems or death later in life compared to similar people who didn't donate. Researchers used health records from 1992 to 2024 to track heart attacks, strokes, and deaths. The g…

This study looked at how inflammation and cholesterol levels relate to heart disease risk in people with rheumatoid arthritis (RA). Researchers used a special heart scan to measure blood flow. The goal was to see if lowering inflammation could improve heart health. The study incl…

This study used national health survey data to estimate how many US adults with high cholesterol might be eligible for the drug inclisiran, and how many heart attacks or strokes could be prevented over 10 years. Researchers analyzed information from over 1,300 participants to ide…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from the same households to understand how culture and family ties help or hinder these conversations. The goal i…

This study looked at 20 people with CADASIL, a rare genetic disease that damages arteries in the brain and can cause migraines, strokes, memory loss, and dementia. The goal was to learn more about how the disease works by doing detailed exams, brain scans, and lab tests over two …

This study looked at 80 childhood cancer survivors who had received a type of chemotherapy called anthracyclines. The goal was to see if special heart MRI scans and blood tests could find early signs of heart damage before standard tests could. The researchers hope this will help…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or a related heart condition called supravalvar aortic stenosis (SVAS). The goal was to create a resource for future research into why symptoms vary so much from person to person. Partici…

This study looked at 70 breast cancer survivors to see how their physical activity levels relate to heart disease risk. Participants wore a special armband to track activity and had their heart risk scored. The goal was to gather information on whether staying active can help pro…

This study looked at whether inflammation is linked to heart disease and diabetes. Researchers compared 150 adults with these conditions to healthy volunteers using blood tests, heart scans, and tissue samples. The goal was to better understand the relationship, not to test a new…

This study looked at how family members talk about genetic health risks like sickle cell, diabetes, cancer, and heart disease. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand how sharing this information …

This study looked at 404 adults aged 40-59 to see if a diagonal crease on the earlobe (Frank's sign) is linked to smoking and heart disease risk. Researchers compared smokers, former smokers, and non-smokers to find out if the crease appears more often in people who smoke. The go…

This study looked at how two types of trans fats—one from milk and one from processed oils—affect heart disease risk. Forty-six healthy adults ate special foods containing either natural or artificial trans fats for a set time. Researchers measured changes in cholesterol and othe…

This study tested how different types of milk fat affect heart health in 107 healthy adults. Researchers changed cows' diets to produce milk with varying levels of trans fats, then measured participants' cholesterol and other heart risk factors. The goal was to understand which m…

This study looked at how long-term lack of sleep affects heart health and weight gain in women. Researchers compared premenopausal and postmenopausal women to see if sleep loss leads to higher blood pressure, worse blood sugar control, and more belly fat. The goal was to understa…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70 using gentle suction and a pencil-like probe. The goal w…

This study looked at how different diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems after losing weight. Over 200 adults took part, and researchers measured their energy use by having them drink special water and trackin…

This study looked at whether giving veterans their genetic test results could help doctors better manage heart disease. 112 veterans with certain gene changes were followed for 6 months to see if their cholesterol levels improved. The goal was to learn how to return genetic infor…

This study looked at how psoriasis, a skin condition caused by inflammation, might be linked to heart disease and other metabolic problems. Researchers followed 386 adults with psoriasis for up to 4 years, using blood tests, heart scans, and imaging to measure inflammation in blo…

This study looked at how certain gene variations affect the health of blood vessels in 178 healthy adults. Participants had an ultrasound and a short-acting medication to measure blood flow. The goal was to learn more about genetic risks for heart disease, not to provide treatmen…

This study looked at 99 adults with high heart risk to see how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity and used scans to check artery thickness and calcium. The goal was to learn if CETP can serve as a marker for heart disease,…

This study aimed to understand how blood vessel stiffness in people with Williams Syndrome and related conditions affects organs like the heart, brain, and kidneys over time. Researchers followed 159 participants, including healthy volunteers, for up to 10 years with yearly check…