NIH study probes hidden impact of stiff arteries in rare genetic condition

NCT ID NCT02840448

Completed Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over up to 10 years using imaging, blood tests, and cognitive assessments. The goal was to better understand the health impacts of reduced elasticity in blood vessels, not to test a treatment.

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Conditions

The condition(s) this trial relates to.

Aortic Stenosis, Supravalvular cardiovascular disorder supravalvular aortic stenosis Williams syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE SUPRAVALVULAR AORTIC STENOSIS WILLIAMS SYNDROME

Contacts and locations

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Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
Washington University School of medicine

St Louis, Missouri, 63110-1093, United States