CARDIOVASCULAR DISEASE

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 24 doctors and 48 patients will take part. The goal is to see if the tool is easy to use and…

This study looks at whether taking fish oil supplements along with the standard medicine metformin can improve heart health in women with Polycystic Ovary Syndrome (PCOS). The study will include 146 women with PCOS who are overweight and have high blood fats or blood sugar issues…

This study tests whether the drug anifrolumab can improve blood vessel health and reduce inflammation in people with lupus, who face higher risks of heart attacks and strokes. About 45 adults with lupus will receive either anifrolumab or a placebo through IV infusions over 8 mont…

This study tests a drug called olpasiran in people with stable heart disease and high levels of lipoprotein(a), a genetic risk factor. The goal is to see if olpasiran can reduce non-calcified plaque in the heart arteries compared to a placebo over 72 weeks. About 406 adults aged …

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have received a heart transplant. Heart transplant patients often face kidney and heart problems due to their condition and required medications. The trial will give …

This study tests an experimental daily pill called AZD0780 to see if it can lower the risk of major heart problems like heart attacks, strokes, and urgent procedures in people who already have heart disease or are at high risk. About 15,100 adults will take either the drug or a p…

This study tests whether a drug-coated balloon can make dangerous fatty plaques in heart arteries less risky than using standard medications alone. About 400 adults with acute coronary syndrome will be randomly assigned to receive either the balloon treatment or no extra treatmen…

This study tests whether having a peer deliver blood pressure medication directly to patients' homes, combined with health technology, can help people take their pills regularly and lower their blood pressure. About 1,140 adults with uncontrolled high blood pressure in western Ke…

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping function will be followed after d…

This study looks at whether taking omega-7 oil (found in fish and macadamia nuts) can improve cholesterol levels and help with appetite control. Researchers will give healthy adults omega-7 supplements for 24 weeks and track changes in their blood fats and eating habits. The goal…

This study is testing a special mattress that can check heart rate, breathing, temperature, and body position without touching the patient. It is designed for adults with heart disease who are staying in the hospital. The goal is to see if this smart mattress works as well as sta…

This large study in Denmark will give the shingles vaccine (Shingrix) to about 162,000 adults aged 65 and older to see if it lowers their risk of heart attacks, strokes, and dementia. Half will get the vaccine, half will not. Researchers will track health records for several year…

This study is testing whether a drug called olpasiran can prevent first major heart problems like heart attacks in people who have high levels of a specific blood fat called lipoprotein(a). It will involve 11,000 participants aged 50+ who have high lipoprotein(a) and other heart …

This study collects blood and tissue samples from people with rare genetic heart or blood vessel diseases, as well as from healthy volunteers. The goal is to find the genetic causes and understand how these diseases work. No treatment is given, but the samples help researchers de…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and can lead to strokes and dementia, over 9 years. Researchers will track changes in blood flow, brain structure, and thinking abilities through regular tests and samples. The goal i…

This study looks at how a common heart medication (beta-blocker) changes the body's inflammatory response to stress. Researchers will measure immune markers and brain activity in 120 healthy adults aged 18-30. The goal is to find new ways to reduce heart disease risk by understan…

This study looks at data from about 3 million people across 40 countries to understand how common risk factors like high blood pressure, smoking, and diabetes affect heart disease and death rates. The goal is to see if these risks vary by geographic region and sex. No treatments …

This early-phase study at UC Davis tests whether a single PET tracer (FDG) can measure both blood flow and sugar metabolism in the heart at the same time. Researchers will compare FDG results with a standard flow-only tracer in 60 healthy adults and people with heart disease. The…

This study uses a survey to find out how aware people with existing heart disease are about their risk factors and future heart problems. Researchers will compare answers from 200 women and men to see if there are differences. The goal is to understand gaps in knowledge so doctor…

This study looks at how whole milk versus skim milk affects blood sugar and cholesterol in adults. Researchers will ask 100 people who drink at least one cup of milk daily to switch between whole and skim milk for a set time. The goal is to see which type of milk is better for he…

This study aims to find the genes that cause primary aldosteronism, a condition where an adrenal gland tumor leads to high blood pressure and low potassium. Researchers will study 1150 Black, African American, or Caribbean individuals aged 18-70 with hard-to-control blood pressur…

This study aims to create and test new MRI methods for imaging the heart and blood vessels. It will involve up to 3,400 adults, including people with heart conditions and healthy volunteers. Participants will undergo MRI scans with possible contrast dye, stress tests, and follow-…

This study uses advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will measure heart rate, blood pressure, and inflammation in arteries and bone marrow. T…

This study looks at how nutrition after heart surgery might affect gut bacteria and overall recovery. Researchers will measure certain chemicals made by gut bacteria in 30 people having heart surgery. The goal is to see if a nutritional intervention can improve metabolic health a…

This study aims to understand the heart health of adults in Black church communities in Washington D.C. Researchers will measure things like blood pressure, cholesterol, and weight, and ask about lifestyle habits. Participants will also wear activity monitors for a month. The inf…

This study is testing an experimental drug called Fx-5A in healthy volunteers to see if it is safe and how the body processes it. The goal is to gather information that could help treat heart disease and inflammation in the future. Participants receive a single infusion of the dr…