Can a heart drug tame stress inflammation?

NCT ID NCT06263452

Recruiting now Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single dose of the beta-blocker propranolol can reduce inflammation caused by psychological stress. Researchers will measure immune markers and brain activity in 120 healthy young adults before and after a stressful task. The goal is to understand the link between stress and heart disease risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Propranolol (a beta-blocker)
What this could lead to: If successful, this study could reveal how stress triggers inflammation and point toward new treatments to lower heart disease risk.
What could go wrong: This is an early-phase, small study (120 people) focused on understanding mechanisms, not testing a treatment. Results may not lead to direct therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE

Contacts and locations

Locations

Social Neuroscience and Health Laboratory
RECRUITING

Chapel Hill, North Carolina, 27514, United States

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