CARDIOVASCULAR DISEASE

This study is testing if giving a cholesterol-lowering drug called evolocumab very early to people hospitalized for a heart attack can help prevent future heart attacks, strokes, or death. It will compare giving the drug plus standard care against standard care alone in over 6,00…

This large study is testing whether a weekly injection called CagriSema can reduce serious heart problems like heart attacks and strokes in people who already have heart disease. About 7,100 participants aged 55+ with a history of heart issues will receive either the real injecti…

This study tests whether a comprehensive program of lifestyle changes, medication, and special heart scans (PET imaging) works better than standard medical care alone for people with or at high risk for heart disease. Over 1,000 participants were randomly assigned to one of the t…

This study is testing whether a probiotic supplement called Probacine can help protect patients' gut health and prevent organ problems after heart surgery. It will involve 500 adults undergoing cardiovascular surgery. Researchers want to see if supporting the gut microbiome leads…

This large, late-stage trial is testing whether a low dose of the blood-thinning drug rivaroxaban can safely reduce the risk of heart attacks, strokes, and death in people with advanced or dialysis-dependent kidney disease. It will enroll 2,000 participants worldwide who have kid…

This study is testing a new oral medication called AZD0780 to see if it safely lowers 'bad' LDL cholesterol in adults who already have heart disease or are at high risk for it. About 3,000 participants will take either the new drug or a placebo (inactive pill) for one year, in ad…

This study is testing a simple, non-invasive method to check blood vessel health in aging Veterans. Researchers move a participant's leg gently while using an ultrasound to measure blood flow, which indicates how well the blood vessels are working. The goal is to see if this test…

This study is testing whether pharmacists can help people lower their risk of heart disease. Over 1,000 adults with conditions like high blood pressure, diabetes, or who smoke will work with pharmacists for up to six months. The goal is to see if this support leads to better bloo…

This study is testing whether a personalized support program can help prevent early deaths in low-income adults. The program provides health navigation, personalized benefits, and compensation for health-related costs to help participants reduce risks from heavy drinking, heart d…

This large study is checking if taking daily vitamin D or fish oil supplements can prevent atrial fibrillation, a common irregular heartbeat, in healthy adults. It's part of a major trial involving over 25,000 people without prior heart disease. Researchers are tracking participa…

This large study aimed to find out if taking daily vitamin D or fish oil (omega-3) supplements could help prevent cancer, heart attacks, and strokes in healthy people. Over 25,000 older U.S. adults without prior cancer or heart disease were randomly assigned to take either the re…

This study aims to understand why African diaspora populations have higher rates of obesity, type 2 diabetes, and heart disease by examining their genetic makeup. Researchers will collect health information and blood samples from about 1,100 adults who identify as African America…

This long-term study follows a diverse group of 3,720 adults in Baltimore over many years. Its main goal is to understand why health differences exist between racial and income groups as people get older. Researchers use mobile medical vans and regular check-ups to collect health…

This large observational study follows over 10,000 adults in Paris for at least 10 years to understand how heart rate patterns, blood pressure regulation, and artery health affect cardiovascular disease risk. Participants undergo heart monitoring, ultrasound tests, and provide bl…

This study is tracking the long-term health of over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill or lived nearby. Researchers are comparing the health of workers who had direct exposure to oil and chemicals with those who did not, to understand if the sp…

This study aims to find better ways to detect heart blood flow problems in women who have chest pain symptoms but no major artery blockages. Researchers will compare results from a standard invasive angiogram test with a non-invasive MRI heart scan. The study will follow 375 wome…

This study aims to better understand the heart, lung, and mental health risks faced by people with rheumatoid arthritis. It will follow 4,000 participants for up to 10 years, using heart scans, lung tests, questionnaires, and blood samples. The goal is to learn how to spot these …

This long-running study is tracking over 1,500 Wisconsin adults to understand how sleep-disordered breathing develops and changes as people age. Researchers are checking in with the same group of people over decades to see how sleep problems might be linked to future heart, brain…

This study aims to understand if a person's genes influence how omega-3 fatty acid supplements affect heart disease risk factors like cholesterol and blood pressure. Researchers are observing 200 healthy adults with higher body weight to see if genetic differences change their re…

This study is testing whether people can reliably collect their own health data at home. Researchers want to see if methods like step counters, simple fitness tests, and questionnaires on a handheld device work well outside a clinic. The goal is to gather information to help desi…

This project is not a new treatment trial, but a large-scale analysis of past research. Researchers are compiling and reviewing results from many existing diet studies to understand if replacing animal protein (like meat and dairy) with plant protein (like beans and nuts) leads t…

This study aims to understand the long-term effects of ketogenic diets on heart health in adults with epilepsy. Researchers are measuring cholesterol, blood pressure, weight, and artery wall thickness over two years. The study includes adults already on the diet and those startin…