CARDIOVASCULAR DISEASE

This study tests a new daily pill, AZD0780, to lower LDL (bad) cholesterol in adults who already have heart disease or are at high risk for it. About 3,100 participants will receive either the study drug or a placebo for 52 weeks, and neither they nor their doctors will know whic…

This study tests a personalized program for low-income adults aged 35-64 who face higher risks of heart disease, heavy drinking, and HIV. The program includes patient outreach, individual health benefits, and help with healthcare costs. Researchers will measure changes in alcohol…

This study tests whether a probiotic supplement called Probacine can protect the gut and reduce organ damage in 500 adults after heart surgery. Researchers believe that changing the gut microbiome may improve recovery. Participants will take Probacine before and after surgery, an…

This study tests whether pharmacists can help people lower their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity will receive pharmacist-led support. The goal is to see if this approach reduces overall cardiovascular risk wi…

This study tests whether giving evolocumab (a cholesterol-lowering drug) very early after a heart attack, along with usual care, can reduce the risk of another heart attack, stroke, artery-clearing procedures, or death. About 6,000 adults hospitalized for a heart attack are parti…

This study tests a weekly injection called CagriSema (cagrilintide plus semaglutide) to see if it can prevent heart attacks, strokes, and other heart-related problems in people who already have heart disease. About 7,100 adults aged 55 and older with a BMI of 25 or higher will re…

This study compares a comprehensive program of lifestyle changes, cholesterol-lowering drugs, and PET heart scans against standard medical care for people with stable coronary artery disease. About 1,085 adults aged 40 and older with suspected or known heart disease are participa…

This large study tested whether taking daily vitamin D and omega-3 (fish oil) supplements could lower the risk of developing cancer, heart disease, or stroke in healthy older adults. Over 25,000 men and women aged 50+ took the supplements for about 5 years. The goal was to see if…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the chance of developing atrial fibrillation (a type of irregular heartbeat) in healthy people. Over 25,000 men and women without prior heart disease or stroke took part. Researchers are checking…

This study aims to collect genetic information and health data from 1,100 adults of African ancestry (including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa) to better understand why obesity, type 2 diabetes, and heart disease are common in these popul…

This study follows 4,000 people with rheumatoid arthritis (ages 50-75) over 10 years to learn more about their risk for heart disease, lung problems, and mental health issues. Participants get a special heart CT scan, lung tests, and questionnaires. The goal is to better identify…

This study follows 1,545 adults over many years to learn how sleep-disordered breathing and other sleep problems develop and affect health. Researchers use overnight sleep tests and questionnaires to track sleep patterns, along with medical exams to measure heart, brain, and mood…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill in the Gulf of Mexico. Researchers want to see if exposure to oil and chemicals during cleanup leads to long-term health problems like heart disease, cancer, or lung issues. Participant…

This study looks at whether people can reliably measure their own physical activity, fitness, and body size at home using simple tools like pedometers and tape measures. Researchers will check if these home-based methods are practical and accurate for 62 adults with low risk for …

This study is a review of many smaller studies that looked at what happens when people replace animal proteins (like meat, dairy, and eggs) with plant proteins (like beans, nuts, and seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressu…

This study follows over 10,000 healthy adults aged 50-75 for at least 10 years to understand how heart rate and blood pressure changes relate to future heart problems, including heart attack, stroke, and sudden death. Participants undergo simple tests to measure these body functi…

This study follows thousands of Black and white adults in Baltimore over many years to understand how race and income differences lead to health problems like heart disease, diabetes, and memory loss as people age. Participants complete health exams, questionnaires, and some get …

This study is a large registry that collects medical information, lab results, and tissue samples from 30,000 people with heart disease and healthy volunteers. The goal is to learn more about what causes heart disease and how different treatments affect patient outcomes. Particip…

This study looks at whether genetic differences influence how omega-3 fatty acids (found in fish oil) affect heart disease risk factors like cholesterol and blood pressure. About 200 healthy adults aged 18-50 with overweight or obesity will take omega-3 supplements and have their…

This study looks at 433 women with chest pain but no major blockages in their heart arteries. Researchers compare standard angiograms with noninvasive cardiac MRI to find problems in small heart arteries. The goal is to improve detection and understanding of heart disease in wome…

This study looks at how ketogenic diets (like the modified Atkins diet) impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. About 105 adults aged 18 and older who are already on or startin…

This study explores whether a simple, non-invasive test called passive leg movement can measure blood vessel health in older adults. Researchers will use ultrasound to see how blood flow changes when a person's leg is moved without their effort. The goal is to create a tool that …