Can Heart-Smart strategies protect men with prostate cancer?

NCT ID NCT03127631

Ongoing Disease control Sponsor: McMaster University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how prostate cancer treatments, especially hormone therapy, affect heart health. It includes two parts: one that follows men over time to track heart problems, and another that tests whether a program of healthy eating, exercise, smoking cessation, and medications like statins can lower heart risks. The goal is to find better ways to care for the whole person, not just the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

statin, ACE inhibitor, nutrition advice, exercise advice, smoking cessation advice

What this could lead to

If successful, this could show that managing heart health alongside prostate cancer treatment reduces the risk of heart attacks, strokes, and death.

What could go wrong

This is an observational and interventional study, not a cure trial. Results may not apply to all prostate cancer patients, and lifestyle changes can be hard to maintain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE PROSTATE CANCER

Contacts and locations

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Locations

Beneficência Nipo-Brasileira de São Paulo. Hospital Nipo-Brasileiro

São Paulo, São Paulo, 02189-000, Brazil
Centre Universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada
Centro Médico São Francisco

Curitiba, Paraná, 80810-050, Brazil
Centro de Pesquisa Clínica do Brasil

Brasília, Federal District, 71625175, Brazil
FOSCAL

Floridablanca, Santander Department, Colombia
Faculdade de Medicina da Universidade Estadual Paulista - Campus de Botucatu - UNESP

Botucatu, São Paulo, 18618-687, Brazil
Flinders Medical Center

Adelaide, South Australia, 5042, Australia
Fundacao Doutor Amaral Carvalho

Jaú, São Paulo, 17210080, Brazil
Fundacio Valle de Lili

Cali, Valle del Cauca Department, Colombia
Fundação Faculdade Regional de Medicina de São José do Rio Preto

São José do Rio Preto, São Paulo, 15090-000, Brazil
Georgia Cancer Center at Augusta University

Augusta, Georgia, 30912, United States
Grand River Hospital, Grand River Regional Cancer Centre

Kitchener, Ontario, N2G 1G3, Canada
Heart Institute - Holon Medical Center

Holon, 5840608, Israel
Hopital Maisonneuve-Rosemont

Montreal, Quebec, H1T 2M4, Canada
Hospital Alemao Oswaldo Cruz

São Paulo, São Paulo, 01327001, Brazil
Hospital Felício Rocho

Belo Horizonte, Minas Gerais, 30110-934, Brazil
Hospital Mae de Deus

Porto Alegre, Rio Grande do Sul, 90840-440, Brazil
Hospital Municipal de Barueri

Barueri, São Paulo, 06463-320, Brazil
Hospital Santa Marcelina

São Paulo, São Paulo, 08270-120, Brazil
Hospital Universitario San Ignacio

Bogotá, Cundinamarca, Colombia
Hospital Universitário São Francisco na Providência de Deus

Bragança Paulista, São Paulo, 12.916-542, Brazil
Hospital de Caridade de Ijuí

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Instituto D'Or de Pesquisa e Ensino

São Paulo, São Paulo, 4543000, Brazil
Instituto De Medicina Integral Prof. Fernando Figueira - IMIP

Recife, Pernambuco, 50.070-902, Brazil
Instituto Nacional de Cardiologia

Rio de Janeiro, Rio de Janeiro, 22240-006, Brazil
Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and Fundação Zerbini (Incor)

São Paulo, São Paulo, 05403-000, Brazil
Integral Pesquisa e Ensino

Votuporanga, São Paulo, 15501-405, Brazil
Irmandade Da Santa Casa De Misericórdia De Porto Alegre

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Istanbul University

Istanbul, Turkey (Türkiye)
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Juravinski Cancer Centre

Hamilton, Ontario, L8V1C3, Canada
Laval University

Québec, Quebec, G1V 0A6, Canada
London Health Sciences Centre

London, Ontario, N6A 5W9, Canada
London Health Sciences, Victoria Hospital

London, Ontario, N6A 5W9, Canada
Marina Leonardo

São Paulo, São Paulo, 04014-002, Brazil
McGill University

Montreal, Quebec, H3A 0G4, Canada
Niagara Health, St. Catharines Site

Niagara, Ontario, L2S 0A9, Canada
Nucleo de Pesquisa Clinica Hospital do Rocio

Campo Largo, Paraná, Brazil
Ottawa Hospital Research Institute

Ottawa, Ontario, K1H 8L6, Canada
Queen's University

Kingston, Ontario, K7L 3J7, Canada
Rabin Medical Center

Petah Tikva, 4941492, Israel
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Santa Casa de São Paulo (IPITEC)

São Paulo, São Paulo, 01223-001, Brazil
Sociedade Hospitalar Angelina Caron

Campina Grande do Sul, Paraná, 83.430-000, Brazil
St. Joseph's Healthcare

Hamilton, Ontario, L8N4A6, Canada
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Tel-Aviv Sourasky Medical Centre

Tel Aviv, 6423906, Israel
Universidade Federal do Triângulo Mineiro

Uberaba, Minas Gerais, 38025-260, Brazil
University Health Network, Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2C1, Canada
University Hospital of Montreal

Montreal, Quebec, H2X 0A9, Canada
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M9, Canada
Westmead Hospital

Westmead, New South Wales, 2145, Australia