Can lowering cholesterol more aggressively help seniors with heart disease?

NCT ID NCT05361421

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study compares two cholesterol-lowering strategies in adults aged 75 and older who have heart or blood vessel disease. One group aims for a very low LDL cholesterol target (below 55 mg/dL) using high-intensity statins, while the other receives standard moderate-intensity statin therapy. The goal is to see if the more aggressive approach reduces the risk of heart-related death, heart attacks, strokes, or the need for procedures to open blocked arteries.

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Conditions

The condition(s) this trial relates to.

atherosclerotic cardiovascular disease cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Yonsei University Health System, Severance Hospital

    Seoul, South Korea