Could a common diabetes drug shield heart transplant patients from kidney damage?

NCT ID NCT06625073

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney function and reduces heart and metabolic risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Empagliflozin (Jardiance)
What this could lead to: If it works, this could provide a new way to protect kidney and heart health in heart transplant recipients, reducing complications.
What could go wrong: This is a relatively small, early-phase trial in a specific population (veterans). The drug may not show clear benefits or could cause side effects like infections or dehydration.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder impaired renal function disease kidney disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE HEART TRANSPLANT KIDNEY DISEASE

Contacts and locations

Locations

Hunter Holmes McGuire VA Medical Center, Richmond, VA
NOT_YET_RECRUITING

Richmond, Virginia, 23249-0001, United States
Michael E. DeBakey VA Medical Center, Houston, TX
NOT_YET_RECRUITING

Houston, Texas, 77030-4211, United States
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
NOT_YET_RECRUITING

Nashville, Tennessee, 37212-2637, United States
VA Palo Alto Health Care System, Palo Alto, CA
NOT_YET_RECRUITING

Palo Alto, California, 94304-1207, United States
VA Salt Lake City Health Care System, Salt Lake City, UT
RECRUITING

Salt Lake City, Utah, 84148-0001, United States
William S. Middleton Memorial Veterans Hospital, Madison, WI
NOT_YET_RECRUITING

Madison, Wisconsin, 53705-2254, United States

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