Could skipping the breathing tube make heart transplants safer?
NCT ID NCT07758894
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial compares two anesthesia approaches for adults undergoing heart transplantation: a newer method that avoids routine breathing tubes and lets patients breathe on their own sooner, versus conventional anesthesia with a breathing tube. The goal is to see if the gentler method reduces major heart and lung complications and shortens recovery time. About 300 participants will be randomly assigned to one of the two approaches and followed for up to a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Non-intubated spontaneous ventilation anesthesia (NISVA) using a supraglottic airway, compared with conventional endotracheal general anesthesia
- What this could lead to
- If successful, this approach could make heart transplant surgery safer and speed up recovery by reducing breathing-related complications.
- What could go wrong
- This is an early-stage trial, and the less invasive method may not suit all patients. Safety risks could require switching to standard anesthesia during surgery.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The First Affiliated Hospital of Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, 450051, China
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