NIH launches study to unravel mysteries of rare genetic brain disease CADASIL
NCT ID NCT02821780
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 11 times
Summary
This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better understand CADASIL, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could help researchers better understand how CADASIL progresses, potentially pointing toward future treatments.
- What could go wrong
- This is a small, observational study with only 20 participants. It is not testing any treatment, so it will not directly lead to a cure or therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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Nationwide Children s Hospital
Columbus, Ohio, 43205, United States
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