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Chocolate pill and multivitamin put to the test against heart disease and cancer

NCT ID NCT02422745

Completed Prevention Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This large study tested whether taking daily cocoa extract (a source of flavanols) or a standard multivitamin could lower the risk of heart disease and cancer in over 21,000 older adults. Participants took the supplements or placebos for several years, and researchers tracked heart attacks, strokes, and cancer diagnoses. The goal was to see if these common supplements could be a simple way to prevent major diseases.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cocoa extract and multivitamin
What this could lead to
If effective, this could point toward a simple, daily supplement to help prevent heart disease and cancer in older adults.
What could go wrong
This is a large completed trial, but supplements often show mixed results; benefits may be small or absent, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm cancer prevention target cardiovascular disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CARDIOVASCULAR DISEASE

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109, United States

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