Diet order may matter: Low-Carb first could boost fat loss

NCT ID NCT06325722

Recruiting now Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 6 times

Summary

This study tests whether starting with a low-carb diet and then switching to low-fat leads to more body fat loss than the opposite order. Over 8 weeks, 42 overweight adults will eat only provided meals and track their weight, activity, and glucose. Researchers want to see if diet order makes a real difference when people live at home.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-carbohydrate diet and low-fat diet
What this could lead to: If it works, this could show that starting with a low-carb diet leads to more fat loss, even when switching diets later.
What could go wrong: This is a small, early-stage study with only 42 people. Results may not apply to everyone, and the effect may be small or not repeatable at home.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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