Could an existing drug treat sickle cell? researchers launch blood sample hunt

NCT ID NCT00542230

Recruiting now Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study collects blood samples from 250 adults with sickle cell disease, sickle cell trait, or healthy red blood cells. Researchers will use these samples to screen thousands of compounds, including FDA-approved drugs, to find ones that stop red blood cells from sickling. The goal is to discover a potential new treatment for sickle cell disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could point toward existing FDA-approved drugs that might be repurposed to treat sickle cell disease.
What could go wrong: This is an early-stage sample collection study, not a treatment trial. It may not identify any effective drugs, and any findings would need further testing in patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sickle cell disease Sickle Cell Trait

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL ANEMIA SICKLE CELL DISEASE SICKLE CELL TRAIT

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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