New imaging study aims to personalize thyroid cancer radiation doses

NCT ID NCT03841617

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This study tests two ways of preparing people with advanced thyroid cancer for a special PET scan that uses a radioactive form of iodine (I-124). The goal is to see which preparation method gives better information for calculating the right dose of radiation therapy. Thirty participants will be followed for five years to see how well the predicted doses match the actual response to treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
I-124 (radioactive iodine for imaging)
What this could lead to
If successful, this study could help doctors choose the best way to prepare patients for radioactive iodine therapy, potentially making treatment more effective and safer.
What could go wrong
This is a small, early-phase study (30 people) focused on imaging, not treatment outcomes. The results may not lead to changes in standard care.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma Neoplasm Metastasis thyroid cancer Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

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