National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study is testing if a drug that blocks growth hormone can help people with severe insulin resistance caused by rare fat storage disorders or specific genetic mutations. Twenty-five adults will give themselves daily injections of the drug for one month while researchers measu…

This study is testing whether a combination of two injectable drugs can help control chronic Hepatitis B infection. It will involve about 50 adults with a mild or inactive form of the disease. Participants will receive monthly and weekly injections over six months, with the goal …

This study is testing if two different immune-suppressing medications can help children survive a sudden, life-threatening liver failure without needing a transplant. About 160 children, aged 1 to 18, will be randomly assigned to receive one of the two drugs or standard supportiv…

This study is testing whether combining two existing drugs, rituximab and cyclosporine, is safe and more effective for treating membranous nephropathy, an autoimmune disease that damages the kidneys' filters. The goal is to reduce harmful protein loss in urine and achieve lasting…

This study is testing if a medication called semaglutide, currently used for diabetes, can help people with non-alcoholic fatty liver disease (NAFLD). Researchers want to see if the drug can reduce liver fat and inflammation. They are also studying how the liver reacts to sugar t…

This study is testing whether a cholesterol-lowering drug called rosuvastatin can safely slow the progression of liver cirrhosis. It will involve about 256 adults with early-stage cirrhosis who are not yet experiencing severe complications. Participants will take either the drug …

This study is testing a new type of PET/CT scan to help doctors calculate the best and safest dose of radioactive iodine treatment for people with advanced thyroid cancer. It will compare two different methods of preparing the body for treatment. The goal is to see if this new sc…

This study is testing whether a gentle, non-invasive electrical stimulation to a specific part of the brain can help people eat less and lose weight. Overweight adults will receive either real or fake stimulation while following a reduced-calorie diet for several weeks. Researche…

This study aims to find better ways to locate the small, hard-to-find tumors that cause a rare form of Cushing syndrome. Researchers will test two new types of PET scans (called F-DOPA and 68Ga-DOTATATE) in up to 80 patients to see which scan, or combination of scans, is most acc…

This study aims to improve a test used to diagnose Cushing's syndrome, a condition caused by too much of the stress hormone cortisol. Researchers want to see if they can make the test more accurate at figuring out the specific cause of the disorder. They will test the procedure o…

This National Institutes of Health study aims to collect information and samples from adults with various endocrine (hormone-related) disorders. Researchers will observe and document these conditions to build a research database, improve physician training, and enable future stud…

This is a long-term observational study aiming to understand why young people with type 2 diabetes are at higher risk for heart and blood vessel disease. It will follow 930 participants aged 12-25 for up to 25 years, comparing those with diabetes, those who are overweight, and he…

This study is testing whether the order people follow two popular diets affects how much body fat they lose. Overweight adults will try both a low-fat diet and a low-carb diet for 4 weeks each, with the order randomly assigned. Researchers will deliver all meals to participants' …

This study aims to understand how a mother's health, weight, and blood sugar during pregnancy affect her child's growth and risk for obesity, diabetes, and fatty liver disease later in life. Researchers will follow 1,500 Hispanic and American Indian/Alaska Native mothers and thei…

This study aims to understand how carcinoid tumors develop and spread in families with a history of this cancer. Researchers will observe 1,600 family members over time, using regular check-ups and scans to track the disease. The goal is to find better ways to detect it early and…

This study aims to learn more about hormone-related conditions like diabetes and thyroid disease by collecting health information and samples from adults. Participants will have medical exams and may provide blood, saliva, or tissue for research. The goal is to help doctors bette…

This National Institutes of Health study aims to better understand what causes dangerously low blood sugar levels during fasting. Researchers will evaluate 1,500 adults who experience low blood sugar when they haven't eaten for a while. Participants will undergo supervised fastin…

This study aims to find the best way to conduct a standard meal test used in nutrition research. Healthy volunteers will eat two different test meals—one a fixed size for everyone and one adjusted to their body's needs—while researchers measure their blood sugar response. The goa…

This study aims to collect information and samples from people with liver diseases to better understand how these conditions develop and progress over time. It will enroll up to 8,050 participants, including people with various liver conditions and healthy volunteers for comparis…

This study aims to understand the biological causes of Primary Sclerosing Cholangitis (PSC), a rare and serious chronic liver disease. Researchers will collect extensive samples—like blood, stool, and tissue—and perform various tests on about 143 adult participants with PSC over …

This early-stage study is exploring whether a drug called mirabegron can activate the body's 'brown fat,' a special type of fat that burns calories. Researchers want to see if this activation can improve how the body uses insulin and manages energy in adults, including some women…

This study aims to collect medical data and samples from people being treated for digestive problems. Researchers will gather this information during participants' regular doctor visits to use in future studies. The goal is to build a resource that helps scientists better underst…

This study aims to understand how a low-carbohydrate diet and a dietary supplement called nicotinamide riboside (NR) affect the body's metabolism. Researchers will measure how these interventions change the way healthy, overweight adults and people with a specific genetic form of…

This study aims to understand why some Black individuals develop primary aldosteronism, a condition where adrenal gland tumors cause severe high blood pressure. Researchers will examine the genes of 1,150 participants with difficult-to-control blood pressure to identify genetic c…

This study aims to better understand the causes, progression, and genetics of thyroid disorders like Graves' disease, hyperthyroidism, and hypothyroidism. It will follow 2,500 patients over time, collecting health data and samples during their standard medical care. The goal is t…

This study aims to understand why and how serious liver scarring develops in adults who had a Fontan procedure for congenital heart disease. Researchers will observe 100 participants over time, collecting blood, stool, and liver tissue samples to identify new markers of disease s…

This study aims to understand the many factors that influence body weight by observing and measuring physical and behavioral traits in adults. Researchers are recruiting 2,000 healthy adults of all body sizes—lean, overweight, and obese—to participate. The study involves detailed…

This study aims to understand how obesity relates to heart disease risk in Black men and women, as past research shows the connection may be different than in other groups. Researchers will enroll 2000 healthy, non-diabetic Black adults to measure body fat, blood fats, and how th…

This study aims to find the genes that make some people with diabetes more likely to develop serious kidney disease. Researchers are recruiting 100,000 people, focusing on families where one member already has diabetic kidney disease, to compare their DNA. The goal is to understa…

This study aims to understand why people with diabetes often have lower vitamin C levels in their blood. Researchers will compare vitamin C measurements in blood and urine from 5,000 people with and without diabetes. The goal is to determine if people with diabetes lose more vita…

This study aims to develop better tools for measuring what people eat by testing if stable isotopes in blood, hair, and fat can track sugar intake from soda. For 13 weeks, 60 healthy adults will live at the NIH and follow controlled diets with different amounts of soda. Researche…

This study aims to understand how the number of calories you eat changes the energy your body uses to digest and process food. Healthy volunteers will live in a clinic for about 35 days, eating controlled diets while researchers measure their metabolism in special rooms. The goal…

This study aims to understand how noncirrhotic portal hypertension (NCPH) develops and progresses over many years. Researchers will follow 400 people aged 12 and older who either have NCPH or are at risk for it due to other conditions like cystic fibrosis. The study involves regu…

This study aims to understand why some people develop insulin resistance, a condition that can lead to diabetes and other health problems. Researchers will collect blood and sometimes skin samples from about 1,200 people, including those with severe insulin resistance, their fami…

This study aims to create better formulas for measuring how the human body uses energy (metabolism). Researchers will compare 2000 healthy volunteers and people with conditions like diabetes or cancer. They will use detailed scans and breath tests during short hospital stays to u…

This study aims to understand how fat tissue works in people with a rare condition called familial partial lipodystrophy (FPLD), where the body stores fat abnormally. Researchers will compare small fat samples from 5 people with FPLD to samples from 5 healthy volunteers. The main…

This study aims to gather information about pregnancy in women with lipodystrophy, a rare condition involving a lack of fat tissue. Researchers want to understand if taking a hormone-replacement drug called metreleptin during pregnancy affects the mother's health or the health of…

This study aims to learn how different types of body fat, especially calorie-burning 'brown fat,' work in human metabolism. Researchers will collect small samples of fat and muscle tissue from adults already having planned surgery at the NIH. The goal is to gather basic knowledge…

This study aims to learn more about parathyroid disorders by observing people who have them or are at risk. Researchers will collect health information and samples over time to understand what causes these conditions and how they progress. The goal is to gather knowledge to help …

This study aims to understand how non-medullary thyroid cancer runs in families. Researchers will follow 500 participants from affected families over time to learn about the disease's natural course, identify possible genetic causes, and determine the best ways to screen for it e…

This study aims to develop better MRI scanning methods to see the heart and arteries in more detail without using radiation. Researchers will compare these new MRI techniques to standard heart tests in up to 4000 adults, including both healthy volunteers and people with or at ris…

This study is testing whether a special imaging scan can better detect thyroid cancer that has spread and doesn't respond to standard treatment. Researchers will give 54 adults with advanced thyroid cancer a PET/CT scan using a radioactive tracer called 68Gallium-DOTATATE. The go…

This study aims to learn more about how to best diagnose and treat thyroid nodules and thyroid cancer. It will enroll up to 2,500 adults and children who have or are suspected of having a thyroid nodule or cancer, or who have a family risk. Researchers will collect blood, tissue,…

This study aims to find new drug treatments for sickle cell disease by collecting small blood samples from volunteers. Researchers will test these samples against thousands of existing compounds to see if any can prevent the red blood cell damage that causes the disease. The stud…

This National Institutes of Health study aims to better understand kidney diseases caused by immune system problems. Researchers will observe 2,000 patients with conditions like nephrotic syndrome and lupus nephritis to learn about disease patterns, symptoms, and treatment respon…