New scan spots hidden thyroid tumors that resist standard treatment

NCT ID NCT04927416

Recruiting now Diagnosis Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a special PET scan using a radioactive tracer called 68Gallium-DOTATATE can better detect thyroid cancer that has spread and no longer responds to standard radioactive iodine therapy. About 54 adults with metastatic thyroid cancer will receive one injection of the tracer and undergo a PET/CT scan. The goal is to see how many participants have tumors that light up on the scan, which could guide future treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 68Gallium-DOTATATE (a radioactive tracer for PET/CT scans)
What this could lead to: If successful, this imaging method could help doctors identify which thyroid cancer patients might benefit from treatments targeting a specific tumor marker (SSTR2).
What could go wrong: This is a small, early-phase imaging study, not a treatment trial. It may not lead to direct patient benefits, and the tracer's ability to improve outcomes is unproven.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma medullary thyroid gland carcinoma metastatic malignant neoplasm Neoplasm Metastasis thyroid cancer thyroid Hurthle cell carcinoma Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTIC THYROID CANCER

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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