National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study tested whether the blood thinner clopidogrel can prevent early failure of arteriovenous fistulas (connections between an artery and vein) in people with kidney failure who need hemodialysis. 877 adults were enrolled. The drug reduced the risk of fistula blockage but di…

This study looked at whether lifestyle programs can help overweight or obese pregnant women control weight gain during pregnancy and improve health for both mom and baby. 123 women receiving care at the Phoenix Indian Medical Center took part. Some joined a weekly group program f…

This study looked at whether vitamin E can help adults with nonalcoholic fatty liver disease (NAFLD). Researchers tested different doses in 200 people to see which one best lowered liver enzyme levels. The goal was to find a safe and effective dose for controlling the disease.

This study tested a new, less invasive way to measure stomach acid using a wireless capsule (SmartPill) that you swallow. It compared the capsule to the standard method that uses a tube placed through the nose into the stomach. The study included healthy volunteers and people wit…

This study looked at whether quercetin, a compound found in many foods, can change how the body absorbs sugar. Researchers gave 24 obese adults, some with type 2 diabetes, either quercetin or a placebo during a sugar-drink test. They measured blood sugar levels to see if querceti…

This study tested a ceramide-based foot cream to see if it could reduce dryness and water loss in the feet of people with non-insulin dependent diabetes. Ten adults with moderate to severe foot dryness applied the cream twice daily for two weeks. The goal was to improve skin hydr…

This study tested whether taking the hormones hydrocortisone and melatonin can reduce jet lag symptoms after a long eastward flight. 57 healthy adults flew across 6-8 time zones and took either the hormones, a combination, or a placebo for 4 days. Participants reported their symp…

This study tested whether amitriptyline, a drug already used for depression and chronic pain, can relieve symptoms of painful bladder syndrome (also called interstitial cystitis). 271 newly diagnosed adults took part. The goal was to see if the drug reduces bladder pain and frequ…

This study tested whether pregabalin, a drug used for nerve pain, can reduce pain and urinary symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. 324 men took either pregabalin or a placebo for 6 weeks. The main goal was to see if symptoms improved enough to ma…

This study looked at how stress from the COVID-19 pandemic affected eating behaviors and weight in over 5,000 English-speaking adults. Participants completed online surveys about their mental health, eating habits, and weight changes. The goal was to understand the connection bet…

This completed study aimed to better understand kidney scarring diseases like focal segmental glomerulosclerosis (FSGS) and chronic kidney disease of unknown cause. Researchers studied 537 participants through medical tests, blood and urine samples, and kidney biopsies to learn h…

This study looked at how lean and obese people respond to not having water. Researchers wanted to see if body fat affects thirst and water balance. 75 healthy men stayed in the hospital for 13 days and had tests like a 24-hour water fast and salt water infusions. The goal was to …

This study looked at how the amount of water you drink affects vitamin C levels in your blood. Healthy adults aged 18-35 followed a low-vitamin C diet and then took vitamin C pills and injections. Researchers measured their blood and urine to understand how the body processes vit…

This study involved 273 people with Zollinger-Ellison syndrome, a rare condition where tumors in the pancreas or small intestine cause too much stomach acid. Researchers used imaging tests and genetic screening to find and manage these tumors. The goal was to improve how doctors …

This completed study looked at how people with chronic liver disease (like hepatitis B, C, or fatty liver) respond to COVID-19 vaccines. Researchers measured antibody levels and tracked COVID-19 infections over 6 months in 233 adults. The goal was to see if liver disease severity…

This study looked at how vitamin E is absorbed and used by the body in normal-weight, overweight, and obese women, including those with type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after different meals and vitamin C doses. The goal was to better un…

This study followed over 8,600 newborns at genetic risk for type 1 diabetes to identify environmental triggers like infections or diet that may cause the disease. Researchers tracked the appearance of diabetes-related autoantibodies and later development of type 1 diabetes. The g…

This study aimed to uncover the genetic and lifestyle factors that cause pre-diabetes to turn into type 2 diabetes. Over 1,700 healthy adults aged 18 to 55 underwent detailed tests of how their bodies handle sugar and store fat. Researchers hope these findings will lead to better…

This study looked at how many organ transplant patients in the US have been exposed to hepatitis E virus. Researchers tested blood from 447 adults who had a liver, kidney, or small bowel transplant, or were waiting for one. The goal was to see if hepatitis E is a common problem i…

This study looked at why some people become obese by examining eating behaviors and food preferences, especially for high-fat foods. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake m…

This study looked at how bacteria from the intestines travel to the liver in people with hepatitis C and liver scarring. Researchers wanted to understand why this happens and if it makes liver disease worse. Thirty adults with stable liver disease took part, providing blood, stoo…

This study looked for better ways to measure what people eat by checking for natural markers in blood and hair. Fifty-nine healthy men ate carefully controlled diets for 12 weeks while researchers tracked changes in these markers. The goal was to see if these markers could reliab…

This study looked at how healthy adults burn calories when exposed to different temperatures, from cool to warm. Researchers wanted to learn if brown fat—a type of fat that burns energy to keep you warm—becomes active in adults when it's cold. The goal was to better understand wh…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food after eating. Researchers compared metabolism in 53 adults, including those with NAFLD, those with related metabolic conditions, and healthy volunteers. Participants stayed in …

This study looked at how the adrenal glands work in 225 critically ill patients, including those with sepsis. The goal was to better understand adrenal insufficiency, a common but poorly defined condition in the ICU. Researchers measured hormone levels to help develop better diag…

This study tested whether people with chronic hepatitis B could safely stop taking antiviral drugs after at least 4 years of treatment. Fifteen adults who had undetectable virus levels stopped their medication and were closely monitored with monthly blood tests for 6 months, then…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 took part, staying in a special room that measured their calorie burn. The goal wa…

This study looked at how type 2 diabetes works in children and young adults aged 12 to 25. Researchers gave some participants insulin shots to give their pancreas a rest and checked if that helped insulin production. They also compared diabetic and non-diabetic volunteers to lear…

This study looked at 146 healthy women of African, African-American, and white backgrounds to see if risk factors for diabetes and heart disease differ by race. Participants completed several visits including blood tests, glucose tolerance tests, body fat measurements, and meal t…

This study looked for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afric…

This study looked at why foreign-born adults in the US often struggle to get proper care for chronic hepatitis B. Researchers surveyed 274 participants about their background, immigration experience, and healthcare access. The goal was to identify barriers like language, culture,…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how participants' bodies burned calories during periods of controlled overeating and fasting. The goal was to see if these measurements could predict an individual's w…

This is a long-term observational study that has been tracking the health of residents of the Gila River Indian Community since 1965. The purpose is to understand what causes Type 2 diabetes and its complications, like heart and eye problems. Eligible community members receive re…