National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study aimed to find out if people with chronic hepatitis B could safely stop taking their antiviral medication after at least four years of successful treatment. Researchers monitored 15 patients who stopped their drugs to see if their infection stayed under control or got w…

This study tested whether quercetin, a natural substance found in foods like apples and onions, could help control blood sugar. Researchers gave 24 adults with obesity or type 2 diabetes either quercetin or a placebo during sugar tolerance tests to see if it slowed sugar absorpti…

This study tested whether the blood thinner clopidogrel could prevent early blood clots in newly created dialysis fistulas. It involved 877 adults with kidney failure who needed a fistula for hemodialysis. Researchers wanted to see if taking clopidogrel for six weeks after surger…

This study aimed to find the best dose of Vitamin E to help adults with nonalcoholic fatty liver disease (NAFLD), a condition where fat builds up in the liver. Researchers tested three different doses of Vitamin E against a placebo in 200 participants over 24 weeks. The main goal…

This study aimed to find better ways to locate and diagnose the tumors (gastrinomas) that cause Zollinger-Ellison syndrome (ZES). It involved 273 patients who were already receiving medical treatment for ZES. Researchers tested different imaging scans to pinpoint the tumors and c…

This study tested a new, easier way to measure stomach acid. Researchers compared a small, swallowable wireless capsule (called SmartPill) to the standard, uncomfortable method that uses a tube down the nose. They tested it in healthy volunteers and in people with conditions that…

This study tested whether a weekly lifestyle program could help overweight or obese pregnant women manage their weight gain and reduce diabetes risks. It involved 123 women who received either the intensive program with group classes or standard care with extra health information…

This study tested whether taking hydrocortisone (a stress hormone), melatonin (a sleep hormone), or both could help travelers feel less jet-lagged. It involved 57 healthy adults taking a planned eastward flight across 6 to 8 time zones. Participants took the study pills for four …

This study tested whether a medication called pregabalin could help men with chronic pelvic pain and discomfort. Over 300 participants were randomly assigned to receive either pregabalin or a placebo pill for six weeks to see which was better at reducing pain and improving qualit…

This study tested whether amitriptyline, a medication typically used for depression, could help people newly diagnosed with painful bladder syndrome. Researchers enrolled 271 adults who experienced bladder pain and frequent urination, randomly giving them either the medication or…

This small study tested whether applying a special moisturizing cream containing ceramides twice daily for two weeks could help reduce foot dryness and prevent water loss in people with type 2 diabetes. It involved 10 adult participants who had moderate to severe foot dryness. Th…

This study aimed to understand why foreign-born adults in the US have difficulty getting proper care for chronic hepatitis B. Researchers surveyed 274 immigrants with hepatitis B about their experiences with the healthcare system. The goal was to identify barriers like language, …

This study aimed to understand how the human body burns calories at different room temperatures, focusing on a special type of fat called brown fat. Researchers enrolled 104 healthy adults to stay in a specialized room where temperatures were carefully controlled, from cool to wa…

This study aimed to better understand how type 2 diabetes develops and progresses in children, teenagers, and young adults. Researchers compared 82 young people with diabetes to healthy peers, measuring how their bodies process sugar, store fat, and handle exercise. The goal was …

This is a long-term observational study to understand why type 2 diabetes is so common and how its complications develop in the Gila River Indian Community. Researchers have been following community members, including over 12,000 participants, with regular health exams since 1965…

This study aimed to understand how the stress and changes from the COVID-19 pandemic affected people's eating habits and weight. Over 5,000 English-speaking adults participated by completing online surveys about their stress, mental health, and eating behaviors over time. The goa…

This study aimed to understand if certain genes make people more likely to develop a serious kidney disease called Focal Segmental Glomerulosclerosis (FSGS). Researchers collected blood samples from over 600 people, including patients with FSGS, people with HIV, and healthy volun…

This study aimed to understand how bacteria from the gut might move into the liver and bloodstream in people with hepatitis C-related liver disease. Researchers enrolled 30 adults with stable hepatitis C and varying levels of liver scarring. Participants underwent detailed testin…

This study aimed to discover what in the environment—like viruses, diet, or stress—might trigger type 1 diabetes in children who are genetically at risk. Researchers followed over 8,600 newborns with a family history of diabetes or high-risk genes from infancy, collecting health …

This study aimed to understand why some people develop type 2 diabetes by looking at genetic and environmental factors. Researchers enrolled 1,759 adults to measure their body composition, insulin function, and glucose tolerance, and collected tissue and DNA samples. The goal was…

This study aimed to understand how women's bodies absorb and use vitamin E, an important antioxidant. Researchers enrolled 50 women, including some who were obese or had diabetes, to measure how different amounts of dietary fat and vitamin C affect vitamin E levels in the blood a…

This study aimed to find a more accurate way to measure what people eat by testing substances in blood and hair. Researchers fed 59 healthy men specific diets for 12 weeks to see if these body samples could reliably show how much meat, fish, and soda they consumed. The goal was t…

This study aimed to understand why common screening tests for diabetes and heart disease often fail women of African descent. Researchers compared risk factors like blood sugar, body fat, and triglycerides in 146 healthy African, African-American, and white women who were federal…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how healthy volunteers' bodies burned calories during 6-week periods of controlled overeating or reduced eating. The goal was to see if these measurements could help p…

This study aimed to understand why some people are more resistant to weight gain when they overeat. Researchers measured how the body burns calories when 203 healthy participants fasted or ate double their usual calories on different diets (like high-protein or high-fat). The goa…

This study aimed to understand how the body absorbs and uses vitamin C. Researchers first put healthy young adults on a low vitamin C diet, then gradually gave them increasing doses, both by mouth and by injection. They closely measured vitamin C levels in the blood and urine to …

This study aimed to understand if lean and obese people feel thirst and handle water deprivation differently. Researchers compared 75 healthy lean and obese men during a 13-day hospital stay, which included a 24-hour period without water. The goal was to gather basic knowledge ab…

This study aimed to learn more about rare, scarring kidney diseases, including a type that affects agricultural workers in tropical countries. Researchers collected blood, urine, and tissue samples from over 500 participants to study the diseases' causes and progression. The goal…

This study aimed to understand how eating behaviors and food preferences, particularly for high-fat foods, might contribute to obesity. Researchers compared 669 healthy adults from Pima Indian and Caucasian backgrounds using questionnaires and measurements of food intake. The goa…

This study aimed to better understand and define adrenal insufficiency, a condition where the body doesn't produce enough stress hormones, in people who are critically ill. Researchers observed 225 participants, including ICU patients, healthy volunteers, and people with known ad…

This study aimed to understand how common hepatitis E infection is in people who have received organ transplants in the United States. Researchers compared blood samples from 447 adults who had a transplant with those waiting for one to see who had signs of the virus. The goal wa…

This study aimed to understand how people with non-alcoholic fatty liver disease (NAFLD) process food differently than healthy people. Researchers compared 53 participants—some with NAFLD, some with metabolic syndrome but no NAFLD, and healthy volunteers—by monitoring their metab…