Vitamin c mystery: scientists track how water affects absorption

NCT ID NCT00001309

Completed Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 9 times

Summary

This completed study looked at how vitamin C moves through the body in healthy adults. Researchers placed 23 volunteers on a low-vitamin C diet, then gave them increasing doses of vitamin C by mouth and IV. They measured vitamin C levels in blood and urine to see how water intake affects those levels. The goal was to better understand vitamin C's pharmacokinetics, not to treat any disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin C (ascorbic acid)
What this could lead to: If successful, this study could improve understanding of how vitamin C is absorbed and used by the body, potentially guiding future dietary recommendations.
What could go wrong: This is a small, early-phase study in healthy volunteers, not designed to test any treatment. Results may not apply to people with medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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