National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study gives the drug metreleptin to people with partial lipodystrophy, a rare condition that causes abnormal fat storage, high blood fats, and diabetes. Participants have already shown improvement from metreleptin in earlier studies and cannot get the drug elsewhere. The goa…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to diabetes and high blood fats. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This study tests whether giving two immune-calming drugs, rituximab followed by abatacept, can help people newly diagnosed with type 1 diabetes keep making their own insulin longer than rituximab alone. About 74 participants aged 8 to 45 will receive the combo or a placebo over 4…

This study tests two oral drugs (abrocitinib and ritlecitinib) in people aged 12–35 who were diagnosed with type 1 diabetes within the past 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, reducing the need for injected…

This study follows people who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring, cancer, or liver failure. About 121 adults will be monitored for up to 10 years with regular tests, scans, and questionnaires. The goal is …

This study aims to find genetic variations that increase the risk of type 2 diabetes, its complications like kidney disease, and related conditions such as obesity. Over 2,300 adults, especially American Indians and Mexican Americans, will provide health history, blood samples, a…

This study looks at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get kidney damage from diabetes. This knowledge could lead to better treatments or ways to prevent…

This study looks at American Indians with type 2 diabetes who have kidney problems. Researchers want to see if a past treatment (losartan) still helps protect their kidneys years later. About 141 people who were in an earlier study or their relatives can join. No new treatment is…