National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This phase 2 trial tests two oral drugs, abrocitinib and ritlecitinib, in 78 people aged 12-35 who were diagnosed with type 1 diabetes within the last 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, measured by a stimu…

This study tests whether giving two immune-calming drugs (rituximab followed by abatacept) can better preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will receive the drug …

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…