Could calming the immune system save Kids' livers?
NCT ID NCT04862221
First seen Oct 31, 2025 · Last updated May 01, 2026 · Updated 35 times
Summary
This study tests two immune-suppressing medicines—high-dose steroids or a horse-derived antibody—in children with sudden, severe liver failure. The goal is to see if calming the body's overactive immune response helps more children survive without needing a liver transplant. About 163 children aged 1 to 17 will take part in this blinded, placebo-controlled trial.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Healthcare of Atlanta - Arthur M. Blank Hospital
WITHDRAWNAtlanta, Georgia, 30322, United States
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Children's Hospital Boston
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Vanderbilt
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic Children's
RECRUITINGCleveland, Ohio, 44195, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Medical Center - Duke Children's
WITHDRAWNDurham, North Carolina, 27710, United States
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Lucile Packard Children's Hospital
RECRUITINGPalo Alto, California, 94304, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NYP Morgan Stanley Children's Hospital
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Primary Children's Medical Center
WITHDRAWNSalt Lake City, Utah, 84112, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Louis Children's Hospital
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Children's Mercy Hospital
RECRUITINGKansas City, Missouri, 64108, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Mount Sinai Medical Center
WITHDRAWNNew York, New York, 10029, United States
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UT Southwestern Medical Center Children's Health
RECRUITINGDallas, Texas, 75235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco Benioff Children's Hospital
WITHDRAWNSan Francisco, California, 94158, United States
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Yale New Haven Children's Hospital
WITHDRAWNNew Haven, Connecticut, 06510, United States
Conditions
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