Can calming the immune system save Kids' livers?

NCT ID NCT04862221

Ongoing Disease control Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tests whether two drugs that calm the immune system—high-dose steroids or anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of these drugs or a placebo. The main goal is to see if more children are alive with their own liver 21 days after treatment.

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Conditions

The condition(s) this trial relates to.

acute liver failure hepatic encephalopathy Hepatic Insufficiency immune system disorder liver disorder liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LIVER FAILURE ACUTE LIVER INJURY FULMINANT HEPATIC FAILURE HEPATIC ENCEPHALOPATHY IMMUNE DYSREGULATION

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Children's Hospital Boston

Boston, Massachusetts, 02115, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital Vanderbilt

Nashville, Tennessee, 37232, United States
Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Lucile Packard Children's Hospital

Palo Alto, California, 94304, United States
NYP Morgan Stanley Children's Hospital

New York, New York, 10032, United States
Rady Children's Hospital

San Diego, California, 92123, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
The Children's Mercy Hospital

Kansas City, Missouri, 64108, United States
UT Southwestern Medical Center Children's Health

Dallas, Texas, 75235, United States

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