National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study is testing whether combining a dietary supplement (alpha-lipoic acid) with an existing medication (mirabegron) can help the body process sugar and burn fat more effectively in people with obesity. Researchers will enroll 60 adults with obesity to take the combination f…

This study is testing whether a new drug called rezpegaldesleukin can help preserve the body's remaining insulin production in people recently diagnosed with type 1 diabetes. Sixty-six participants, aged 8 to 45, will receive either the drug or a placebo injection every two weeks…

This study is testing a new radioactive drug designed to target and treat a rare, aggressive form of thyroid cancer called Hurthle cell cancer. It is for adults whose cancer has spread and no longer responds to standard radioactive iodine treatment. The main goals are to find a s…

This study aims to see if two new types of imaging scans are better at finding parathyroid tumors before surgery. It will involve about 193 adults who are already scheduled for surgery to remove a parathyroid gland. Researchers will compare the new scans, which use a radioactive …

This study aims to see if two different drugs can delay or prevent the onset of insulin-dependent Type 1 diabetes in people who are at high risk. It will enroll 60 participants, aged 4 to 35, who have early signs of the disease but do not yet need insulin. Participants will recei…

This study aims to understand how diabetes and obesity develop and change over time, especially in younger people. Researchers will collect health information and samples (like blood and saliva) from up to 1,000 participants during their regular doctor visits. The goal is to gath…

This study aims to understand why liver problems are common after a stem cell transplant, a treatment for cancers and other diseases. Researchers will follow 500 children and adults for up to 4 years, performing tests like blood work, scans, and liver biopsies to see who develops…

This study aims to understand if a person's childhood experiences of unpredictability are linked to their adult eating behaviors, metabolism, and weight. Researchers will enroll 110 healthy adults and measure their food intake, physical activity, blood sugar, and body composition…

This study aims to understand how alcohol changes the way the liver handles fat. Researchers will take two small samples of liver tissue from people with alcohol use disorder who are entering a detox program—one sample early on and another a few weeks later. By comparing these sa…

This study aims to understand how eating meals with different nutrients—like high-fat or high-carbohydrate breakfasts—affects fat levels in the blood. Researchers will compare 100 participants, including healthy volunteers and people with conditions like kidney disease or metabol…