National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study tests whether taking a supplement (alpha-lipoic acid) with a drug (mirabegron) can improve how the body handles sugar and insulin in people with obesity. About 60 adults aged 18-65 with a BMI between 30 and 45 will take the combo or a placebo for 4 weeks. The goal is t…

This study tests a radioactive drug called 177Lu-DOTA-EB-TATE in 18 adults with a rare thyroid cancer (Hurthle cell) that has spread and no longer responds to standard radioactive iodine treatment. The drug targets a protein found in high amounts on these cancer cells. Participan…

This study compares two treatments to delay type 1 diabetes in people who are at high risk but don't have symptoms yet. One group gets 2 infusions of ATG, the other gets 14 infusions of teplizumab. Researchers want to see if the shorter ATG treatment works as well or better at pr…

This study follows 500 adults and children who are getting a stem cell transplant to see how their liver health changes over 4 years. Researchers will use blood tests, imaging, and liver biopsies to track liver problems. The goal is to understand why some people develop liver iss…

This study examines how the liver processes fat in people with alcohol use disorder who are going through detox. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity changes as fatty liver resolves. The goal is to bett…

This study looks at how early life events might influence eating behaviors and weight gain in adults. Researchers will measure food intake, physical activity, and blood sugar in 110 healthy volunteers aged 18 to 60. Participants will complete questionnaires, wear activity and glu…

This study aims to collect health information and biological samples from 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic issues. Researchers will follow participants for up to 30 years to learn how diabetes and obesity develop and change over ti…

This study looks at how meals with different amounts of fat, carbs, and protein change fat levels in the blood. Researchers will study 100 adults with conditions like diabetes, metabolic syndrome, or kidney disease, plus healthy volunteers. Participants will eat two different bre…