OVERWEIGHT

This study tests a new weekly injection called NNC0487-0111 for people who are overweight or have obesity and also have obstructive sleep apnea treated with a breathing machine. About 300 adults will receive either the study drug or a placebo for one year. The goal is to see if t…

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, to help adults with overweight or obesity lose weight. About 872 participants will receive either the drugs or a placebo. The main goal is to see how much weight they lose and if the dr…

This study tests a once-weekly injection called NNC0487-0111 to help people with overweight or obesity and moderate-to-severe obstructive sleep apnea (OSA) who do not use a breathing machine. About 300 adults will receive either the study drug or a placebo for up to a year. The g…

This study tests whether two experimental drugs, macupatide and eloralintide, can help people with obesity or overweight lose weight safely. About 400 adults who do not have type 2 diabetes will receive either one or both drugs or a placebo for about 64 weeks. The main goal is to…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through the body.

This study looks at whether drinking special hydrogen-rich water every day can help overweight adults improve their body composition and metabolic health. About 120 participants will be randomly assigned to drink either hydrogen water or a placebo for a period. The goal is to see…

This study is the first time the experimental drug SA030 is being tested in people. It aims to check the safety and how the body handles a single dose in 40 overweight or obese adults aged 18 to 55. Participants will be randomly assigned to receive either SA030 or a placebo, and …

This study tests a new drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese and not on blood pressure medication. The goal is to see if the drug can lower blood pressure and help with weight loss. About 336 adults will take eithe…

This study looks at whether brief, intense stair-climbing sessions, called 'exercise snacks,' can improve blood vessel health and body composition in overweight adults. Sixty participants aged 18-35 will be split into four groups, including a no-exercise control group, for 6-8 we…

This study tests a new weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants will receive two weekly shots (one active, one placebo) for about a year. The main goal is to see how much weig…

This study tests a new weekly pill called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight after losing it. About 120 adults who have already been using weekly injections for weight loss will take either the study drug or a place…

This study tests how well the experimental medicine CagriSema helps people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo injection for roughly one year. The main goal is to measure the percentage of weight lost and check for…

This study looks at whether a type of talk therapy (ACT) combined with a mobile app can help overweight adults who eat in response to stress or negative emotions. About 78 participants will be split into groups: some get group therapy, some get therapy plus the app, and others ar…

This study aims to find the best combination of four dietary strategies—limiting high-calorie foods, eating within a set time window, increasing protein, and increasing fiber—for weight loss in adults with overweight or obesity. Over 12 weeks, 208 participants will track their we…

This study aims to find better ways to deliver health services to women Veterans, especially those in midlife. Researchers will test two different strategies at 18 VA sites to see which one helps more women get the care they need. The study focuses on improving engagement with pr…

This early-stage study tests a single shot of HDM1005 in 30 people, some with kidney impairment and some healthy. The goal is to see how the drug moves through the body and if it is safe. Results will help guide future dosing for people with kidney issues.

This early-stage study looks at how a new drug called HDM1005 affects stomach emptying and interacts with four common medications (metformin, atorvastatin, warfarin, and digoxin) in 42 overweight or obese Chinese adults aged 18-45. The goal is to understand how the body processes…

This study watches how body fat and muscle affect the way anesthesia drugs work in overweight and obese patients. Researchers will measure drug levels and track complications like breathing problems or infections. About 2,100 adults will take part, but no new treatments are being…