OVERWEIGHT

This study tests an experimental drug called BI 3034701 to help people with obesity or overweight lose weight. About 300 adults aged 18-74 will receive either the drug or a placebo injection for 42 weeks, along with diet and exercise advice. Researchers will measure weight change…

This Phase 3 study tests whether a weekly injection called zenagamtide helps Asian adults with overweight or obesity lose weight safely. About 400 participants will receive either the drug or a placebo for several weeks. The main goal is to see how much body weight changes, with …

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This early-stage study tests whether a new drug, eloralintide, can improve how the body responds to insulin and manage weight in 115 adults with overweight or obesity. Participants will receive either the drug or a placebo injection and be monitored for about 35 weeks. The goal i…

This Phase 3 trial will test whether a new drug called zenagamtide helps people with obesity lose more weight than the current treatment semaglutide. About 650 adults will receive weekly injections of either zenagamtide, semaglutide, or a placebo. The main goal is to see how much…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This study investigates whether replacing some wheat flour with legume flours (chickpea, pea, or lentil) in Arabic bread can reduce blood sugar spikes after eating. Overweight or obese adults aged 18–65 will consume different breads and have their blood glucose and appetite measu…

This phase 3 trial tests a once-daily oral drug called aleniglipron for chronic weight management in 3600 adults with obesity or overweight who also have a weight-related health condition. Participants take the drug or a placebo for 76 weeks, along with diet and exercise changes.…

This early-stage study tests an experimental drug called LY4174794 in 108 healthy volunteers who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to measure weight loss. Participants will receive either the drug or a p…

This early-stage study tests whether a new oral drug, VRB-103, is safe and tolerable when taken alone or with another drug (ecnoglutide) in people with obesity or overweight. About 336 participants will receive either the drug or a placebo. The goal is to check for side effects, …

This study tests a web-based program called Confident Moves designed to help adults with obesity increase their physical activity and improve overall health. About 348 adults aged 18-64 with a BMI of 25 or higher will be enrolled. Participants will use an online platform with sel…

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight. Participants must have already been on weekly injections of semaglutide or tirzepatide for at least 6 months. The goal is to find …

This early-stage study will compare two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version for several weeks, and researchers will measure how the drug builds up in the body. The goal is to s…

This early-stage study tests a single dose of SA030 injection in 40 overweight or obese adults aged 18–55. The main goal is to check safety and how the body handles the drug. It is the first time SA030 is given to humans, so results will guide future research.

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

The Reset trial, led by Stanford University, aims to find the best combination of four dietary strategies for weight loss in a fully digital program. 208 adults with overweight or obesity will receive a 12-week remote intervention that includes daily self-weighing, weekly lessons…

This study tests a new medicine called CagriSema to help people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo for around one year. The main goal is to see how much weight they lose and check for any side effects.

This study tests whether drinking hydrogen-rich water every day can help adults who are overweight improve their body composition and metabolism. Researchers will compare hydrogen water to plain water in 120 participants over a period of time. The goal is to see if this simple dr…

This study tests whether tracking only high-calorie, low-nutrition foods (Red Zone Foods) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if a simpler approa…

This study looks at whether brief, intense stair-climbing sessions (called 'exercise snacks') can improve blood vessel function and body composition in overweight adults aged 18-35. Sixty participants will be split into four groups, including a no-exercise control group, for 6-8 …

This study looks at whether a type of talk therapy called Acceptance and Commitment Therapy (ACT), combined with a mobile app, can help overweight people who eat in response to emotions like stress or sadness. About 78 adults will be split into groups: some get group therapy, som…

This observational study looks at how being overweight or obese, and changes in lifestyle, impact work performance, quality of life, and well-being in medical residents. Researchers will track 600 participants for 12 months, measuring body weight, lifestyle habits, and using ques…

This early-stage study is testing a new medicine for overweight and obesity. The main goal is to see how the drug behaves in people with different levels of liver function, from normal to severely reduced. About 35 adults aged 18-80 will take a single dose, and researchers will m…

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study watches how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and drug levels in 2,100 adults during surgery. The goal is to understand why heavier patients may have more complications, …

This early-stage study will test an experimental drug called HDM1005 in 42 overweight or obese adults. Researchers want to see how HDM1005 affects stomach emptying and whether it changes how the body processes common medications like metformin, atorvastatin, warfarin, and digoxin…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…