OVERWEIGHT

This study is testing a 6-month family coaching program to see if it can help manage weight and improve health in young people with type 1 diabetes who are also overweight or obese. The program includes both the child and at least one overweight parent, using a mix of in-person a…

This study is testing whether a new medication called aleniglipron (GSBR-1290) can help people with obesity or overweight manage their weight when combined with diet and exercise. Researchers will compare the drug to a placebo in 82 participants over 44 weeks to see if it's safe …

This study aimed to test the safety and effectiveness of a new combination weight loss pill (sibutramine and topiramate) in overweight or obese adults, some of whom had other health conditions like high blood pressure. It compared the new pill to a dummy pill (placebo) and to one…

This study is testing whether a new pill called VCT220 helps people lose weight and keep it off. About 840 overweight or obese adults will take either a high dose, low dose, or a placebo pill once a day for a full year. Researchers will measure changes in body weight, waist size,…

This study aims to see which of three newer diabetes medications (dulaglutide, semaglutide, and tirzepatide) works best to prevent serious heart problems like heart attacks and strokes in people with type 2 diabetes and overweight. It will analyze health insurance records from 60…

This study is testing whether a new drug called LY3841136, alone or combined with an existing drug called tirzepatide, can help with weight management in adults who have type 2 diabetes and are overweight or have obesity. About 350 participants will receive either the active drug…

This study is testing whether adding intermittent fasting to a weight management program helps veterans keep weight off long-term after they've lost it. Researchers want to see if this eating pattern is better than standard programs at preventing weight regain, which is a common …

This study is testing whether eating almonds as a daily snack can improve fitness, energy levels, and body composition in active, overweight adults aged 50-59. Fifty participants will eat almonds twice a day for 12 weeks and then switch to a different snack for another 12 weeks, …

This study aimed to test how well and safely two different drugs, bimagrumab and tirzepatide, worked alone or together to help adults with obesity or overweight and type 2 diabetes lose weight. The trial was designed to last about 13 months but was withdrawn before any participan…

This early-stage study is testing a new injectable medicine for people with overweight or obesity. The main goal is to check if the medicine is safe and to see how the body absorbs and processes it. About 63 healthy adults will receive either the real medicine or a placebo inject…

This study is testing whether adding high-dose omega-3 fish oil supplements to standard antidepressant medication can help people with depression that hasn't fully responded to treatment. Researchers want to see if the supplements reduce body inflammation and if that reduction is…

This study is testing whether a weekly injection called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. It will compare the medicine to a placebo (dummy shot) to see if it improves long-term blood sugar levels and helps with weight loss. The tri…

This study aims to find the most effective way to help people maintain weight loss after they stop taking medications like Ozempic, Wegovy, Mounjaro, or Zepbound. It will enroll about 226 adults who have successfully lost weight on these drugs but are now stopping them. Participa…

This early-stage study aims to check if an experimental drug called maridebart cafraglutide affects heart rhythm in people with overweight or obesity. It will involve 81 healthy adults to see if the drug is safe for the heart before larger studies can test if it helps with weight…

This study is testing if having a personal guide, called a patient navigator, helps people with overweight or obesity start and continue using proven weight loss methods. The 12-month program provides a counselor who helps participants understand their options and connect with ef…

This study is testing whether a new investigational medicine called cagrilintide helps people with overweight or obesity lose weight and improve their health. About 300 adults will receive either cagrilintide or a placebo (dummy treatment) by random chance for about 18 months. Re…

This study tests whether an educational video and follow-up phone sessions can help veterans start proven weight loss treatments. It involves 440 veterans who are overweight or have obesity but aren't currently in a weight management program. The goal is to see if this simple edu…

This is an early-stage study to check the safety of a new weight loss drug called LY3537031. It will involve about 302 overweight, obese, and healthy volunteers, including some Japanese and Chinese participants. Researchers will give participants the drug and closely monitor thei…

This study is testing two investigational drugs, bimagrumab and tirzepatide, to see how well and how safely they help with weight loss. It will involve about 240 adults who have obesity or are overweight with a related health condition, but who do not have type 2 diabetes. Partic…

This study is testing a weekly injection called tirzepatide for adults who have type 1 diabetes and are also overweight or have obesity. The main goals are to see if it safely improves long-term blood sugar control and helps with weight loss. About 465 participants will be in the…

This study is investigating whether the medication tirzepatide, which is approved for weight loss and diabetes, can improve kidney health in people who are overweight or obese and have chronic kidney disease. Researchers will use special MRI scans to see if the drug increases oxy…

This large, late-stage study is testing whether a once-daily oral medication called orforglipron can help adults with obesity or overweight lose weight and improve related health conditions like high blood pressure or cholesterol. Over 3,100 participants will take the drug or a p…

This study is testing whether a new daily medication called LY3549492 can help adults with obesity or overweight manage their weight. About 288 participants will take either the drug or a placebo (inactive pill) for roughly one year. Researchers will measure changes in body weigh…

This study is testing whether an investigational medicine called cagrilintide helps people with type 2 diabetes and overweight or obesity lose weight and improve their health. About 330 participants will be randomly assigned to receive either the new medicine or a placebo for abo…

This study is testing whether a dietary supplement made from avocados can help overweight adults manage their weight and blood sugar levels. For 16 weeks, 60 participants will take either the supplement or a placebo pill, while researchers track changes in weight, blood sugar, ch…

This study is testing whether adding a new investigational drug called RO7204239 to an existing weight-loss medication (tirzepatide) helps people lose more weight. It will involve about 285 adults who have obesity or are overweight with at least one related health issue, like hig…

This study is testing whether a new weekly oral pill called VRB-101 helps people lose weight compared to a placebo. It involves about 206 adults who have obesity or are overweight with other related health conditions. Participants take the pill or a placebo for 20 weeks to see wh…

This study is evaluating a community program in Rotterdam designed to help children aged 4-12 who are overweight. The program involves various local providers offering activities focused on nutrition, physical activity, and healthy habits. Researchers are measuring the program's …

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This study is testing a new weekly injection called petrelintide to see if it helps people with obesity and type 2 diabetes lose weight and better control their blood sugar. About 221 participants will receive either the drug or a placebo (dummy injection) for comparison. The mai…

This study aimed to see if a daily drink containing a specific probiotic could help manage weight in young children who were gaining weight too quickly. It planned to compare children receiving the probiotic drink to those receiving a placebo drink over three months. The study wa…

This study is testing whether two different blends of plant extracts can help improve blood sugar control in people with prediabetes. It involves 87 overweight adults who will take the supplements for 12 weeks. Researchers will measure changes in blood sugar markers, body weight,…

This Mayo Clinic pilot study aims to see if eating all your daily food within an 8-hour window earlier or later in the day is better for weight loss. It will involve 100 overweight or obese adults. The study will track changes in weight, BMI, blood sugar, and cholesterol, while a…

This large, late-stage study is testing whether the weight-loss medication tirzepatide can reduce serious health events like heart attacks, strokes, and death in adults with obesity. It involves over 15,000 participants who are either over 40 with existing heart disease or are at…

This VA study aims to improve how 20 VA medical centers provide virtual health programs to women Veterans. It's testing two different support strategies to help these facilities successfully offer proven programs for preventing heart disease, diabetes, and depression. The goal is…

This study is testing different ways to help people at high risk for cancer or cancer survivors become more active and eat healthier foods. Researchers are comparing methods like weekly phone calls, emails, daily text messages, and online forums to see which combinations work bes…

This study is testing whether a mobile phone app for parents can help prevent overweight and obesity in school children. About 740 children in Mexico City will participate, with half of their parents using the app for a year to get guidance on healthy eating and physical activity…

This study is testing if a diabetes prevention program, with or without extra training on recognizing hunger, can help people at high risk for breast cancer lose weight. The goal is to see if weight loss from these programs might lower cancer risk. The study enrolled 51 overweigh…

This study is testing a counseling and support program designed to help Chinese and Korean American family members caring for a loved one with dementia. The program includes individual counseling, family sessions, and online chat groups to provide emotional support and health inf…

This study is exploring whether a father's diabetes and weight can leave marks on his sperm that might influence his future children's health risks. Researchers are enrolling 40 overweight men with type 1 or type 2 diabetes to see if a 3-month lifestyle program focused on blood s…

This early-stage study aims to understand how the body absorbs and processes an experimental drug called maridebart cafraglutide (AMG 133) for weight management. Researchers will compare two different injection forms of the drug in 348 adults living with overweight or obesity. Th…

This study aims to collect and store biological samples from 500 people with obesity. The goal is to build a repository of blood, urine, and tissue to help researchers understand why weight loss treatments sometimes work or fail, and why weight is often regained. This is an obser…

This study looks at existing health records to understand if taking the weight-loss medication Wegovy during pregnancy affects the health of mothers and babies. Researchers will compare about 1,100 pregnancies where women took Wegovy to pregnancies where they didn't. The goal is …

This study aims to understand if eating different types of olive oil changes markers linked to heart disease risk, like cholesterol levels and inflammation. It involves 44 healthy adults aged 20-45. Participants eat two olive oils (one high-polyphenol, one low-polyphenol) for two…

This project is not a new treatment trial, but a large-scale analysis of past research. Researchers are compiling and reviewing results from many existing diet studies to understand if replacing animal protein (like meat and dairy) with plant protein (like beans and nuts) leads t…

This study is collecting information about pregnancy outcomes for women who take Wegovy (semaglutide) for weight management. Researchers will compare about 728 pregnant women who take Wegovy with similar women who don't take the medication. They'll track birth outcomes, complicat…