OVERWEIGHT

This early-stage study tests whether the drug RO7204239 can improve how the body uses insulin in people with type 2 diabetes who are also overweight or obese. About 30 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure changes in insu…

This study tests two experimental drugs, LY3841136 and tirzepatide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 350 participants will take the drugs or a placebo for up to 64 weeks. The goal is to see if these treatments are…

This early-stage study is testing a new medicine called LY3537031 in people who are overweight or obese, as well as healthy volunteers. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure changes in body weight and blood sugar …

This study tests whether a once-weekly medicine called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. About 465 participants will receive either tirzepatide or a placebo for around 20 months. The main goals are to see if it improves blood sugar…

This study tests a once-daily pill called orforglipron against a placebo in 600 adults with obesity or overweight who also have type 2 diabetes. The goal is to see if the pill helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or high…

This study tests a new tablet called VCT220 to help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo pill once daily for 12 months. The main goal is to see how much weight they lose and if it improves health markers…

This study was designed to test a new combination of two drugs (sibutramine and topiramate) for helping overweight adults with conditions like high blood pressure or diabetes lose weight. It was a large, carefully controlled trial that planned to compare the new drug against a pl…

This study tests a once-daily tablet called orforglipron to see if it helps people with obesity or overweight lose weight. About 600 adults who do not have diabetes will take either the drug or a placebo for around 18 months. The main goal is to measure how much weight they lose …

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps people with obesity or overweight lose more weight over 48 weeks. About 285 adults without diabetes will participate. The goal is to see if the combination i…

This study tests a family-based weight management program for youth with type 1 diabetes (ages 6-17) who are overweight or obese, along with one parent who is also overweight. The program adapts a proven treatment for home delivery, aiming to improve weight, blood sugar control, …

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 adults who do not have type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if the…

This large Phase 3 study tests a once-daily tablet called orforglipron against a placebo in 1,200 adults with obesity or overweight, some of whom also have type 2 diabetes. The goal is to see if the drug helps with weight loss and is safe. Participants are split into two groups b…

This study tests whether a once-weekly medicine called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. About 905 participants will receive either tirzepatide or a placebo for about 49 weeks. The main goals are to see if it improves blood sugar c…

This study tests whether tirzepatide, a medication for weight management, can reduce the risk of major health events like heart attacks, strokes, and death in over 15,000 adults with obesity or overweight. Participants must have a BMI of 27 or higher and either have existing hear…

This study tests whether a daily avocado supplement (Metavo) can help overweight adults manage their weight and blood sugar. Over 16 weeks, 60 participants will take either the supplement or a placebo, and researchers will track changes in body weight, blood glucose, and other he…

This study tests an investigational medicine called cagrilintide to see how much it helps people with overweight or obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to measure the perc…

This study tests a culturally tailored support program for Chinese and Korean American caregivers of relatives with dementia. The program combines counseling with online peer support groups to help reduce stress, depression, and health risks like diabetes and heart disease. Resea…

This study aimed to test two drugs, bimagrumab and tirzepatide, alone or together, for helping adults with obesity or overweight and type 2 diabetes lose weight. Participants would have taken injections for about 13 months to see how much weight and body fat they lost. However, t…

This study tests a new medicine, cagrilintide, to help people with obesity or overweight lose weight. About 300 adults will receive either the drug or a placebo for around 18 months. The main goals are to see how much weight they lose and how many achieve at least a 5% weight red…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are also overweight or have obesity. The goal is to see if it helps with weight loss and, for a smaller group, improves sleep apnea. Participants will receive either the drug …

This study tests a new weekly injection called petrelintide to help people with overweight or obesity and type 2 diabetes lose weight. About 221 adults will receive either the drug or a placebo for several weeks. The main goal is to see how much weight they lose and how their blo…

This study tests a new weekly pill, VRB-101, to help people with obesity or overweight who also have weight-related health problems lose weight. About 206 adults will receive either the drug or a placebo for several weeks. The main goal is to see how much weight they lose compare…

This study tests whether two plant-based supplements can help manage blood sugar in prediabetic, overweight adults. 87 participants will take either a polyphenol-rich extract, that same extract plus white kidney bean and minerals, or a placebo for 12 weeks. Researchers will measu…

This study tests a once-daily oral medication called orforglipron for weight loss in adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea. About 3,100 participants will take either the drug or a placebo for 72 weeks, wi…

This study looks at whether intermittent fasting can help overweight veterans aged 50-75 keep weight off after losing it. About 175 veterans will try this eating pattern to see if it prevents weight regain. The goal is to find a simple, low-cost way to manage weight and reduce he…

This study tests whether video consultations are as effective as in-person hospital visits for helping overweight children aged 9-11 lose weight. After an initial visit, children are randomly assigned to continue treatment either at the clinic or via video calls. The goal is to s…

This study tests whether two drugs, bimagrumab and tirzepatide, can help adults with obesity or overweight lose weight safely. About 240 participants will receive one or both drugs or a placebo for around 70 weeks. The main goal is to see how much body weight changes from the sta…

This study tests an investigational drug called taldefgrobep alfa to see if it helps adults with overweight or obesity lose weight. About 150 participants will receive either the drug or a placebo by injection for 24 weeks, with an option to continue in an open-label extension. T…

This study aimed to see if a probiotic protein drink could help control weight gain in children aged 2 to 5 who were gaining weight too quickly. Children would have received either the probiotic or a placebo for 3 months. However, the study was withdrawn before any participants w…

This study is testing a new once-weekly medicine called NNC0662-0419 to see if it is safe and helps people with overweight or obesity lose weight. About 224 adults will receive either the study drug or a placebo (a shot with no active medicine). The main goals are to check for si…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can improve kidney function in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Participants will have MRI scans to measure kidney oxygen levels and fat content ov…

This study tests if a mobile app for parents can help prevent overweight and obesity in school children aged 5-11 in Mexico City. About 743 children from four schools will take part; some parents get the app, others don't. The app gives tips on healthy eating and physical activit…

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese participants lose weight and potentially lower their breast cancer risk. About 51 people at high risk for breast cancer will take part. The main goal is to see if the pr…

This study tests different programs to help people at high risk for cancer eat healthier and exercise more. The goal is to see which approach works best to increase physical activity and improve diet. About 337 people with a high BMI, low activity, or poor diet are taking part. T…

This early-stage study tests a new injectable medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body processes it. About 63 adults will receive either the study drug or a placebo injection. This is not a cure but…

This study looks at whether eating almonds twice a day for 12 weeks can improve physical function, aerobic capacity, and activity levels in overweight but active adults aged 50-59. Participants will compare almond snacks to a calorie-matched control snack. The goal is to see if a…

This pilot study is testing a new exercise-focused group for adults who are overweight or have obesity. The goal is to see if the group helps people increase their physical activity without also increasing unhealthy eating or exercise behaviors. Twelve participants will wear Fitb…

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight. About 100 participants will follow one of two eating schedules for a set time. Researchers will track weight changes, blood sugar levels, and any challenges people f…

This early-stage study tests how the body processes two different injection forms of maridebart cafraglutide, an experimental drug for overweight or obesity. About 348 adults aged 18-60 with a BMI between 25 and 40 will receive a single dose and be monitored for drug levels and s…

This early-stage study tests whether maridebart cafraglutide, a potential weight-loss drug, affects the heart's electrical activity. About 81 adults with overweight or obesity will receive the drug, a placebo, or a positive control to measure changes in heart rhythm. The goal is …

This study looks at community programs in Rotterdam that help overweight children aged 4 to 12 and their families adopt healthier habits. About 1,000 children will take part in activities focused on diet, exercise, and motor skills. Researchers will measure changes in quality of …

This study tests whether a patient navigator (a personal guide) can help adults with overweight or obesity choose and stick with proven weight loss programs. 68 participants will receive a navigator for 12 months. The goal is to see if this approach improves weight loss and progr…

This study looks at how two different kinds of olive oil affect heart disease risk factors. Researchers will measure changes in cholesterol, inflammation, and gene activity in 44 healthy adults of various weights. The goal is to see if olive oil polyphenols can improve cardiovasc…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study looks at medical records from 60,000 people with type 2 diabetes and obesity to compare three drugs (dulaglutide, semaglutide, tirzepatide) against an older drug (sitagliptin) for preventing heart attacks, strokes, and death. The goal is to see which drug works best in…

This study is a review of many smaller studies that looked at what happens when people replace animal proteins (like meat, dairy, and eggs) with plant proteins (like beans, nuts, and seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressu…

This study looks at how pretzels made with safflower oil and soy affect energy use in postmenopausal women who are overweight and have metabolic syndrome. Twenty women will eat different pretzels for one month each to see how their bodies digest them. The goal is to learn if thes…

This study observes pregnant women who took Wegovy for weight management and compares their health and their babies' health to pregnant women with similar conditions who did not take Wegovy. Researchers will follow infants for one year after birth to check for birth defects or ot…

This study looks at whether being overweight or having diabetes changes certain chemical marks on sperm DNA. Researchers will check if a 3-month lifestyle or blood sugar program can improve these marks. The study involves 40 men aged 18-65 who are overweight, with or without diab…

This study uses insurance records to compare pregnancy outcomes in women who took Wegovy (semaglutide) during pregnancy versus those who did not. Researchers will look at birth defects, low birth weight, and other health issues in mothers and babies. The goal is to help patients …

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, not individual patients. The goal is to see which strategies work best to get women to sign …

This study looks at whether an educational video and motivational coaching sessions can help more veterans start obesity treatments like weight management programs, medications, or surgery. About 440 veterans who are overweight or have obesity will take part. The goal is to see i…