OVERWEIGHT

This Phase 3 trial tests whether cagrilintide, a new injectable drug, helps people with overweight or obesity lose weight. About 300 adults will receive either cagrilintide or a placebo for up to 18 months, along with lifestyle counseling. The study measures weight change and wai…

This study tests whether tirzepatide, a once-weekly injection, helps teenagers with obesity or overweight (with related health issues) lose weight. About 160 teens will receive either tirzepatide or a placebo for 72 weeks, alongside lifestyle advice. The main goal is to see if bo…

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This early-stage study tests an investigational drug called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will receive single or multiple doses …

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This phase 3 trial is testing different ways to increase the dose of retatrutide, a new weight-loss drug, in 600 people with obesity or overweight who do not have type 2 diabetes. The study lasts about 113 weeks and measures weight loss, waist size, and other health markers. The …

This study compares two popular weight-loss medications, tirzepatide and semaglutide, in 100,000 adults who are overweight or obese and at risk for heart problems but do not have diabetes. Researchers are analyzing real-world data to see which drug better prevents death, heart at…

This study tests a program called SANOS that teaches Mexican adults how to eat healthy without spending a lot of money and how to be more active. About 1,785 overweight or obese participants will receive counseling and be followed for up to a year. The goal is to see if this appr…

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This phase 2 study tests two drugs, bimagrumab and tirzepatide, alone or together, to see if they help adults with obesity or overweight lose weight safely. About 252 participants without type 2 diabetes will take the drugs or a placebo for up to 70 weeks. The main goal is to mea…

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps adults with obesity or overweight lose more weight over 48 weeks. About 285 participants without diabetes will receive either the combination or a placebo pl…

This study tests whether a new weekly injection called IBI362 works better than the existing drug semaglutide for weight loss and reducing liver fat in overweight or obese Chinese adults with metabolic dysfunction-associated fatty liver disease (MAFLD). About 479 participants wil…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 905 adults with type 1 diabetes who are also overweight or obese. Participants will receive either tirzepatide or a placebo for about 49 weeks. The study measures changes in blood sugar control (HbA1c) and body wei…

This study tests a new medicine called NNC0662-0419, given as a weekly shot, to see if it helps people with overweight or obesity lose weight safely. About 224 adults aged 18-65 with a BMI of 27 or higher will receive either the drug or a placebo. The main goals are to check for …

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This study tests whether video consultations are as effective as in-person hospital visits for treating overweight in children aged 9-11. After an initial visit, children are randomly assigned to continue care either at the clinic or via video calls. The goal is to see if remote …

This Phase 3 trial tests a daily pill called orforglipron to see if it helps people with obesity or overweight lose weight. About 600 participants will take either the drug or a placebo for around 18 months. The study focuses on weight reduction and related health measures like w…

This Phase 3 trial is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight lose weight, both in those with and without type 2 diabetes. About 1,200 participants will take either the drug or a placebo for a set period. The goal is to f…

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This Phase 3 trial is testing a once-daily pill called orforglipron in 600 adults who are overweight or have obesity and also have type 2 diabetes. The study compares the drug to a placebo to see if it helps lower blood sugar and body weight over about 18 months. Participants mus…

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 participants without type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if it is…

This early-stage trial tests whether a drug called RO7204239 can improve how the body uses insulin and affects muscle composition in 30 adults with type 2 diabetes who are overweight or obese. Participants will receive either the drug or a placebo, and researchers will measure ch…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This phase 3 trial tests whether VCT220, a daily pill that targets GLP-1 receptors, can help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo for 12 months. The main goals are to see how much weight they lose and ho…

This study tests a new drug called taldefgrobep alfa (BHV-2000) to help adults with overweight or obesity lose weight. About 150 participants will receive either the drug or a placebo as a weekly or monthly injection for 24 weeks. The main goal is to see how much body weight chan…

This study evaluates 12 different healthy lifestyle programs for children aged 4 to 12 who are overweight. About 1,000 kids and their parents will take part in activities like sports, nutrition advice, and behavior coaching. Researchers will measure changes in quality of life, BM…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 465 adults with type 1 diabetes who are also overweight or obese. Participants receive either tirzepatide or a placebo for about 20 months. The study measures changes in blood sugar control (HbA1c) and body weight …

This study tests whether a patient navigator (a weight loss counselor) can help adults with overweight or obesity choose and stick with an evidence-based weight loss program. 68 participants will work with a navigator for 12 months. The goal is to see if this support improves wei…

This early-stage trial is checking whether maridebart cafraglutide, a new weight-loss drug, affects the heart's electrical activity. About 81 adults with overweight or obesity will receive the drug or a placebo, and their heart rhythms will be closely monitored. The main goal is …

This early-stage study tests a new drug called LY3537031 in overweight, obese, and healthy volunteers. The main goal is to check safety and how the body handles the drug. Researchers will also measure weight changes and blood sugar levels. The study involves about 300 people and …

This 16-week study tests whether an avocado-based dietary supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo daily, and researchers will track changes in body weight, glucose levels, …

This Phase 2 trial tests a once-weekly injection called petrelintide in 221 people with overweight or obesity and type 2 diabetes. Participants receive either petrelintide or a placebo for several weeks. The main goal is to see how much weight they lose and whether blood sugar im…

This phase 3 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can reduce the risk of heart attacks, strokes, heart failure, and death in over 15,000 adults with obesity. Participants either have established heart disease or are at high risk. The …

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 …

This was a planned phase 3 study to test a new combination of two drugs, sibutramine and topiramate, for weight loss in overweight and obese adults. The study aimed to see if the combination worked better than either drug alone or a placebo. However, the trial was withdrawn befor…

This study tests a new daily pill, orforglipron, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea lose weight. About 3,100 participants will take either the pill or a placebo for 72 weeks, with some continui…

This study tests a program called TOTAL that uses an educational video and three telemedicine calls to encourage veterans with obesity to start weight loss treatments like the MOVE! program, medications, or surgery. About 440 veterans will take part. The goal is to see if this si…

This study aimed to test two drugs, bimagrumab and tirzepatide, alone or together, for helping adults with obesity or overweight and type 2 diabetes lose weight. It was planned for about 13 months but was withdrawn before enrolling any participants. The main goal was to see how m…

This study tests two drugs, LY3841136 and tirzepatide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 350 participants will take the drugs or a placebo for up to 64 weeks. The goal is to see if these treatments are safe and eff…

This study tests two plant-based supplement blends in 87 overweight adults with prediabetes. Over 12 weeks, researchers measure changes in blood sugar markers like HbA1c and post-meal glucose. The goal is to see if these natural extracts can help manage blood sugar levels.

This study planned to give a probiotic supplement or a placebo to toddlers aged 2–5 who were gaining weight faster than expected. The goal was to see if the probiotic could help manage weight gain over three months. However, the study was withdrawn before any children were enroll…

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize true hunger. T…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants…

This study tests a mobile app called 'Applícate por tu salud' that sends parents tips, recipes, and videos to encourage healthy eating and physical activity for their school-aged children. About 743 children from 4 primary schools in Mexico City will take part, with some schools …

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 1…

This study looks at whether eating almonds twice a day for 12 weeks can improve physical performance, aerobic capacity, and daily activity in overweight but active adults aged 50-59. Participants will compare almonds to a calorie-matched snack to see if almonds offer extra benefi…

This study tests a culturally tailored counseling and support program for Chinese and Korean American caregivers of relatives with dementia. The program includes family counseling sessions and online peer support groups. Researchers will measure whether it reduces stress, depress…

This early-stage study tests a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it over about 8 weeks. Participants receive multiple doses of the drug, and researchers monito…

This pilot study tests a new group program called Move Healthier, designed to help people with overweight or obesity increase their exercise using cognitive and behavioral skills. The goal is to see if it boosts physical activity without raising the risk of disordered eating. Onl…

This early-stage study tests a new medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body processes it. About 63 participants will receive either the study drug or a placebo as an injection under the skin. The me…

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight and improve health. Researchers will track changes in weight and blood sugar over time. The goal is to find out which eating schedule works best and is easier to stic…

This study looks at health records of about 1,100 women who took Wegovy during pregnancy and compares them to those who did not. The goal is to see if the drug increases risks for birth defects or other problems in babies. Researchers will use insurance claims data to track outco…

This study looks at how long you need to fast and how stopping the diabetes/weight-loss drug tirzepatide changes the amount of food left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 people with type 2 diabetes or obesity. The goal …

This early-stage study tests a single dose of the experimental drug PF-08653944 in 54 overweight or obese adults. Researchers want to see how the drug is absorbed when injected into the abdomen, thigh, or upper arm. The study also monitors safety through blood tests and vital sig…

This study looks at whether pretzels made with safflower oil and soy can help postmenopausal women with metabolic syndrome maintain a healthy weight. Twenty women will eat three different types of pretzels over 14 weeks, and researchers will measure how their bodies process the s…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study looks at how being overweight and having type 1 or type 2 diabetes may change genetic markers in sperm. Researchers will test if a 3-month lifestyle or blood sugar program can improve these markers. About 40 men will provide sperm samples before and after the program.

This study looks at whether the natural compounds in olive oil, called polyphenols, can improve heart health markers like cholesterol, inflammation, and gene activity. Researchers will give two types of olive oil to healthy, overweight, and obese adults aged 20-45. The goal is to…

This study follows pregnant women who took Wegovy for obesity or overweight to see if it affects the baby's health. Researchers compare these women to similar pregnant women who did not take Wegovy. The goal is to check for birth defects and other health issues in infants during …

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…