OVERWEIGHT

This study tests a family-based behavioral program for youth aged 6-17 with type 1 diabetes who are overweight or obese, along with an overweight parent. The program focuses on healthy meal planning, food literacy, and family habits to improve weight and diabetes control. Twenty …

This study tests whether injecting carbon dioxide gas under the skin can safely reduce fat on the flanks (love handles). Healthy adults with a normal body weight will receive the gas on one side and a fake treatment on the other, with no other weight-loss methods allowed. The mai…

This phase 2 study tested a new drug called eloralintide (LY3841136) for weight management in 263 adults with obesity or overweight. Participants received either the drug or a placebo for about 64 weeks. The main goal was to see how much weight they lost after 48 weeks. Results w…

This completed Phase 1 trial tested how the experimental drug maridebart cafraglutide (AMG 133) is absorbed when given as two different injections. 348 adults with overweight or obesity received a single dose. The main goal was to measure drug levels in the blood, not weight loss…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This study tested a new medicine called HS-20094 to help overweight and obese adults lose weight. About 600 people took either the drug or a placebo for up to 48 weeks. The main goals were to see how much weight they lost and how many lost at least 5% of their starting weight.

This phase 3 trial tests whether a daily oral drug called orforglipron can help people with obesity or overweight maintain weight loss they achieved with injectable tirzepatide or semaglutide. About 376 participants who completed a prior weight-loss study will receive orforglipro…

This study looked at whether a 10-week stay at a Danish Christmas Seal Home can improve the health, fitness, and well-being of overweight children aged 7-14. It also tested if adding a special high-intensity activity and health education program (FIFA 11 for Health) made a bigger…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This study tested a once-daily medication called LY3549492 to help adults with obesity or overweight lose weight. About 288 participants took either the drug or a placebo for around one year. The main goal was to see how much weight they lost and how safe the treatment was.

This study tested a daily oral semaglutide tablet (50 mg) for weight loss in 667 adults with overweight or obesity. Participants took the pill or a placebo for 68 weeks, along with diet and exercise advice. The main goals were to measure percentage weight loss and how many people…

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much weight people lost and if at least 5% of body …

This study tested a new drug called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. About 85 adults took either the drug or a placebo for 44 weeks, along with diet and exercise. The main goal was to check safety and side effects, while also measuri…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose more weight and improve their metabolism. A total of 110 people aged 25-35 with a BMI of 24 or higher took part. The results will help guide better dieta…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested a new drug called enicepatide (CT-388) given as a weekly injection for 48 weeks. It involved 469 adults with obesity or overweight who also had at least one weight-related health problem like high blood pressure or prediabetes. The goal was to see how much weigh…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This completed study looked at 226 adults who had lost at least 15% of their body weight while taking GLP-1 medications like Wegovy or Ozempic. Participants stopped their GLP-1 drug and were given either bupropion-naltrexone or bupropion-naltrexone-metformin, plus behavioral supp…

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps overweight adults lose weight and improve their gut bacteria. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, cholesterol, and …

This study tested whether the drug tirzepatide, given once weekly, can help people with obesity or overweight maintain weight loss they achieved during a prior diet period. About 441 participants took either tirzepatide or a placebo for 60 weeks. The goal was to see if the drug c…

This study checks whether survodutide, a new weight-loss injection, affects heart rhythm in 110 overweight or obese adults. Participants receive survodutide or placebo for about 30 weeks, with heart tests before and after. The goal is to see if the drug is safe for the heart, not…

This early-stage study tested an oral drug called orforglipron in 120 adults with obesity or overweight (but without diabetes). The goal was to see how it changes body fat compared to a placebo over about 8 months. Researchers measured fat around organs, appetite, and weight. Thi…

This study tested a daily 25 mg semaglutide pill in 307 adults with overweight or obesity over 64 weeks. Participants taking the drug lost more weight than those on placebo, with many achieving at least 5% body weight reduction. The pill offers a convenient alternative to injecti…

This study tested whether sending specific motivational messages at just the right moment helps young adults with overweight or obesity meet their daily weight loss goals. Over 200 participants used a smartphone app with a weight loss program, and some received extra messages tar…

This study tested a new medicine called NNC0487-0111 for weight control in 36 Chinese adults with overweight or obesity. Participants received either the drug or a placebo injection. The main goal was to check safety and how the drug moves through the body. The trial lasted up to…

This study tested a new daily injection called CT-868 in 103 overweight or obese adults with type 2 diabetes. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if CT-868 could lower blood sugar levels (HbA1c) and help with weight loss.

This early-stage study tests a new drug called eloralintide, alone or combined with tirzepatide, in 188 adults with overweight or obesity. The main goals are to check safety, side effects, and how the drugs move through the body. Participants receive weekly injections under the s…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection, for weight loss in 1200 adults who are overweight or obese and have type 2 diabetes. Participants received either CagriSema or a placebo for about 1…

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over …

This study tested a culturally-tailored program called HARMONY for African American women at risk for heart disease, stroke, and diabetes. Over 8 sessions plus monthly boosters, participants learned stress management, exercise, and healthy eating. The goal was to see if the progr…

This study looked at whether a once-weekly medicine called semaglutide (used for weight loss and diabetes) can lower the risk of heart attacks, strokes, and death in people with overweight or obesity. Researchers analyzed medical records of over 285,000 people in the US. The goal…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This phase 2 study tested three different doses of a new injectable drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults who were overweight or obese, some with type 2 diabetes. The main goal was to see how much weight participants lost over 52 weeks. The…

This study tested a program called Family Check-Up Heart, which adds heart-health coaching to regular home visits for new moms and their babies. About 150 mothers who had Medicaid and recently gave birth took part. The goal was to see if the program could help moms manage weight,…

This study looked at whether increasing everyday physical activities (like walking or housework) along with aerobic exercise improves heart health more than exercise alone in overweight young women. Twenty-eight women were split into two groups: one did only moderate aerobic exer…

This study tested two weight loss programs in 223 overweight or obese adults aged 21-75. One group followed a fixed calorie reduction plan, while the other varied their calorie intake. The goal was to see which approach leads to more weight loss over time.

This study tested whether a natural plant compound called EMIQ can safely help overweight and obese adults lose body fat. Over 12 weeks, 65 participants took either EMIQ or a placebo twice daily. Researchers measured changes in body fat, weight, and other health markers to see if…

This study tested whether giving extra support—like cooking classes, motivational talks, and financial help for physical activity—to overweight teens from less advantaged backgrounds helps them manage their weight as well as standard care helps teens from more advantaged backgrou…

This study tested whether a weekly injection of semaglutide (2.4 mg) helps teenagers with overweight or obesity lose weight. 201 teens aged 12 to 18 took part, receiving either semaglutide or a placebo for about 15 months, along with lifestyle counseling. The main goal was to see…

This completed phase 3 trial tested two injectable weight loss drugs, tirzepatide and semaglutide, in 751 adults with obesity or overweight who also had weight-related health problems like high blood pressure. The study lasted about 74 weeks and measured how much weight participa…

This early-stage study tested a single dose of the investigational drug eloralintide in 30 Chinese adults who are overweight or have obesity. The main goal was to check safety and side effects, and to measure how the drug moves through the body. Participants were randomly assigne…

This study tested whether an 8-week circuit exercise program could improve markers of inflammation in overweight young women. Twenty-two women aged 20-30 were randomly assigned to either the exercise program or their usual routine. The exercise group showed increases in a benefic…

This study tested a new drug called NNC0487-0111, given as an injection under the skin, to see if it is safe and how it works in the body. It included 125 adults aged 18-55 who were overweight or obese. The goal was to help manage weight, but ongoing treatment may be needed.

This study tested whether an online family skills training program is practical and well-liked for Black adults trying to lose weight. 21 participants joined with a family member. The program focused on healthy eating and activity habits.

This early-stage study tested whether adding a new drug (LY3841136) to an existing weight-loss medication (tirzepatide) is safe and tolerable. 96 healthy overweight or obese adults took part over about 42 weeks. The main goal was to check for side effects, not to prove weight los…

This completed Phase 1 trial tested an experimental drug called AMG 133 in 120 adults with overweight or obesity. Participants received multiple doses of the drug or a placebo to see how the body processes it and to check for safety issues. The study did not aim to measure weight…

This study tested whether a probiotic called Weizmania Coagulans BC99 can improve gut bacteria and blood fat markers (like cholesterol) in overweight adults. 72 participants took either the probiotic or a placebo daily for 8 weeks. Researchers collected blood, urine, and stool sa…

This study looked at whether sharing digital self-monitoring data—like weight, steps, and calories—with a friend or family member helps adults with overweight or obesity lose more weight over 24 months. About 320 participants used a wireless scale and Fitbit to track their progre…

This study tested an experimental injection called GZR18 in 340 Chinese adults who are obese or overweight. The goal was to see if it helps with weight loss over 30 weeks compared to a placebo. Participants also followed a stable diet and exercise plan. The results will show how …

This study tested whether low-dose omega-3 supplements (250 mg EPA per day) can improve cholesterol and inflammation in overweight or obese adults with high triglycerides. Forty participants in Chile took omega-3 or a placebo for six weeks each in a crossover design. The goal was…

This study tested a new medicine called NNC0662-0419 in 100 adults who are overweight or obese. The main goal was to check if the drug is safe and how the body handles it. Participants received either the drug or a placebo as a weekly injection under the skin. This is the first t…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This study tested a program to help pregnant women with overweight or obesity avoid gaining too much weight. The program included setting goals, tracking weight, learning skills, and getting support from WIC counselors. 416 women from Philadelphia WIC took part, and researchers m…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower their blood sugar as effectively as a program led by a human coach. About 368 adults with prediabetes and overweight took part. The goal was to see which approach …

This study tested a 6-month home-based program for 300 children ages 2–6 who were overweight or obese. Community health workers visited families to encourage healthy eating, physical activity, and parenting skills. The goal was to see if the program could improve children's weigh…

This study looked at whether an educational program for pregnant women who are overweight or obese could help prevent their babies from gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits. The goal was to reduce th…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women were split into an exercise group and a control group. The exercises focused on core strength and abdominal endurance. Researchers measured lung functio…

This study tested a weight management program called MOVE!+UP, designed specifically for veterans with PTSD who are overweight or obese. The program adds extra support to standard PTSD care to help overcome barriers like stress and unhealthy habits. Researchers compared it to the…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested whether drinking VitalPLANT and Helichrysum italicum teas for one week could improve signs of metabolic syndrome in 30 overweight adults. Participants had at least two components of metabolic syndrome and were not taking any related medications. Researchers meas…

This study tested the safety of a new drug called LY3841136, given alone or with another drug (tirzepatide), in 128 Japanese adults who are obese or overweight. Researchers monitored side effects and how the body processes the drugs over several months. The goal was to see if the…

This completed Phase 1 study tested how CagriSema (a combination of cagrilintide and semaglutide) affects appetite and brain activity in 164 adults with overweight or obesity. Participants received either the drug, a placebo, or no medicine, and researchers measured appetite scor…

This study tested whether whole-body vibration (standing on a vibrating platform) can help overweight and obese university students lose weight and improve body composition. Thirty-two students aged 18-25 with a BMI of 25 or higher took part. Half stood on a real vibrating device…

This Phase 1 study in 40 overweight or obese adults examined how a new drug called HRS-7535 interacts with four common medications: acetaminophen (pain reliever), digoxin (heart medication), rosuvastatin (cholesterol drug), and omeprazole (acid reflux treatment). Participants too…

This study looked at how Enneagram personality types are connected to body weight, eating behaviors, emotional eating, and overall well-being in 210 adults. Participants completed questionnaires about their personality, eating habits, and mental health. The goal was to better und…

This completed study investigated how eating behaviors and food preferences, especially for high-fat foods, contribute to obesity. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake mea…

This study looked at how normal to overweight adults who are already regularly active vary their physical activities and where they do them. About 50 participants wore an armband to track their movement. The goal was simply to describe patterns, not to test any treatment.

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This completed study from Purdue University looked at whether GLP-1 receptor agonists (like Ozempic or Wegovy) change how people taste, smell, and crave food. Researchers compared 90 adults with obesity who were either not taking the drug, or had been taking it for about 1 month …

This study looked at 216 women aged 18-45 to see if weight affects bladder symptoms, hygiene habits, and body awareness. Researchers compared normal-weight women to those who are overweight or obese using questionnaires. The goal was to understand how these factors relate and to …

This completed Phase 1 study looked at how orforglipron, an experimental drug, changes the way the body processes several common medications (digoxin, simvastatin, rosuvastatin, acetaminophen, and midazolam) in 50 healthy overweight or obese adults. The goal was to measure drug l…

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Vietnam. The program included monthly lessons, videos, and support to improve eating habits and physical activity. Researchers compared these children to a control group to see i…

This study examines a Danish law requiring public schools to include 45 minutes of physical activity each day. Researchers measured activity levels and BMI in over 5,000 children before and after the policy took effect. The goal is to see if the mandate actually boosts movement a…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutritional counseling and physical activity. The program included three diet workshops and weekly exercise sessions. Researchers an…

This study tested whether a medical body composition scale (mBCA 555) could pick up early changes in body fat, muscle, and water balance in 41 overweight adults using L112 lipid-binding products. The goal was to find signs of progress that appear before the scale shows weight los…

This completed Phase 1 trial looked at whether multiple doses of Survodutide, a weight-loss drug, change how the body absorbs and processes three common drugs: bupropion (an antidepressant), caffeine, and midazolam (a sedative). Thirty-four otherwise healthy adults with overweigh…

This study follows people who were in the SELECT trial to see how their health changes over the next 10 years. No new medicine is given—participants just fill out a health questionnaire every 6 months. The goal is to learn about long-term effects like heart attacks, cancer, weigh…

This study looked at whether adding a nutrition program to an existing exercise program is practical and well-liked by cancer survivors who are overweight or obese. Twenty adults who finished cancer treatment joined a 12-week program combining diet advice with exercise. The goal …

This early-phase study looked at how a low-fat meal and taking the drug in the evening affect levels of KAI-7535 in the blood. Eighteen healthy adults with overweight or obesity took the drug under different conditions. The goal was to understand the best way to take it, not to t…

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease. Researchers used national survey information to find out how common heart problems are in this group and how they change over time. No treatments were giv…

This study created a registry of 200 overweight children and young adults with high blood pressure to track their heart health over time. Researchers collected medical information from clinic visits to understand how weight affects the heart. No treatments or interventions were g…

This early-stage study tested a new drug called HU6 in 59 overweight adults. The goal was to see how safe the drug is and how the body processes it in tablet and capsule forms. Participants took different doses, and researchers measured drug levels in the blood. This study does n…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This study tested whether taking an anti-nausea drug (ondansetron) along with AMG 133 changes how the body processes AMG 133. Fifty-nine adults with overweight or obesity participated. The goal was to measure drug levels and check for side effects, not to treat the condition.

This early-stage study tested a single dose of the experimental medicine NNC0662-0419 in 100 adults with overweight or obesity. Participants were Japanese, Chinese, or non-Asian to see how the drug behaves in different ethnic groups. The main goals were to measure drug levels in …

This study looked at how eating beans changes the way the body uses fat, carbohydrates, and protein for energy. 36 overweight adults ate meals with beans or bean flour, and researchers measured their energy use in a special room. The goal was simply to understand the effects, not…

This study looked at how giving health information to mothers changes the food choices they make for their young children. Over 1,100 mothers of children ages 3-7 used a virtual reality buffet to pick a meal for their child. Researchers measured the calories selected to see if he…

This study looked at how a new drug called GZR18 is processed in the bodies of 6 overweight or obese men. The drug was given as a single injection, and researchers measured how much of it came out in urine and stool over 78 days. The goal was to understand how the drug is broken …

This study looked at whether community organizations can successfully run a healthy lifestyle program called Deaf Weight Wise (DWW) for Deaf adults who use American Sign Language. The program involved 16 weekly group sessions led by a trained Deaf counselor via Zoom. Researchers …

This study looked at real-world medical records from over 887,000 people with type 2 diabetes, overweight, and heart risk to compare two drugs: tirzepatide and semaglutide. The goal was to see which one better prevents serious heart problems like heart attack, stroke, or death. T…

This early-stage trial tested a single dose of a new drug called SAR441255 in 48 healthy, lean to overweight adults. The main goal was to check safety and how the body processes the drug. Researchers also looked at effects on blood sugar and insulin levels. This is a first step t…

This study looked at how a short, intense running test changes blood sugar, fats, inflammation, and other health markers in normal-weight and overweight/obese teenage girls. 35 girls aged 14-18 completed the Spartacus test, and blood was drawn before, right after, and 30 minutes …

This study looked at how one session of brisk walking or jogging changes appetite-related hormones and brain responses to food pictures in 40 adults with different body weights. Participants exercised for 60 minutes while wearing a mask to measure oxygen use. Researchers measured…