OVERWEIGHT

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study looked at whether a once-weekly medicine called semaglutide can lower the risk of heart problems and other obesity-related health issues in people with overweight or obesity. Researchers analyzed medical records from over 285,000 people in the U.S. to see how semagluti…

This study tested a new once-weekly injection called CT-388 (also known as enicepatide) to help people with obesity or overweight who also have related health problems like high blood pressure or prediabetes. About 469 adults took part, receiving either a low, middle, or high dos…

This study tested a new once-daily medication called LY3549492 to help adults with obesity or overweight lose weight. About 288 people took part for roughly one year. The main goal was to see how much weight they lost compared to those who took a placebo.

This study tested an experimental injection called GZR18 in 340 Chinese adults who were obese or overweight. Participants received either the drug or a placebo, along with diet and exercise advice. The main goal was to see how much weight they lost after 30 weeks. The study is co…

This study tested whether an 8-week circuit exercise program (combining aerobic and resistance moves) could improve inflammation markers in overweight young women. Twenty-two women aged 20-30 with a BMI of 25-31 either exercised four times a week or continued their normal routine…

This study tested a daily semaglutide tablet (25 mg) in 307 adults with overweight or obesity to see if it helps with weight loss. Participants took either the drug or a placebo for 64 weeks. The main goals were to measure the percentage of weight lost and how many people lost at…

This study tested two medications, tirzepatide and semaglutide, to see which works better for weight loss in adults with obesity or overweight who also have related health problems like high blood pressure. About 751 people took part over 74 weeks. The main goal was to measure ho…

This study tested a daily oral tablet of semaglutide (50 mg) to help people with overweight or obesity lose weight. 667 adults took either the active drug or a placebo for 68 weeks, along with lifestyle advice. The main goals were to measure the percentage of weight lost and how …

This study tested a new medicine called CT-868 in 103 overweight or obese adults with type 2 diabetes. The goal was to see if it could lower blood sugar levels and help with weight loss over 26 weeks. Participants received either the drug or a placebo, and researchers measured ch…

This study tested a once-daily pill called orforglipron to see if it helps people with obesity or overweight maintain weight loss they achieved in a previous study. 376 adults who completed the earlier weight-loss program took either the pill or a placebo. The goal was to measure…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose weight and improve metabolic health. A total of 110 people aged 25 to 35 with a BMI of 24 or higher took part. The results will help guide better dietary…

This study tested three doses of a new drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults with overweight or obesity, some of whom also had type 2 diabetes. The main goal was to see how much weight participants lost after 52 weeks. The drug aims to help…

This early-stage study tested a new drug called AMG 133 in 120 adults with overweight or obesity. Researchers gave multiple doses under the skin to see how the drug behaves in the body and whether it is safe. The goal was to gather information for future studies, not to treat or …

This study tested whether giving extra support (like cooking classes, motivational talks, and financial help for physical activity) to less advantaged overweight teens could help them manage their weight as well as standard support helps more advantaged teens. About 1,689 high sc…

This study tested an experimental drug called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. About 85 adults took either the drug or a placebo for 44 weeks, along with diet and exercise. The main goals were to check safety and side effects, and to…

This study tested whether a natural plant product called EMIQ can help overweight and obese adults lose body fat safely. Sixty-five participants took either EMIQ or a placebo for a period of time, and researchers measured changes in body fat using special scans and skin fold meas…

This study looked at whether a three-month supervised exercise program can improve blood sugar, body composition, and fitness in men with type 2 diabetes, prediabetes, or related conditions like overweight and high cholesterol. Three hundred sedentary men aged 35-65 took part in …

This study looked at whether omega-3 fatty acids (fish oil) can improve cholesterol levels and reduce inflammation in overweight or obese adults with high triglycerides. Forty participants took omega-3 supplements or a placebo in a crossover design. The goal was to see if a simpl…

This study tested a new medication, orforglipron, to see how it changes body fat in adults with obesity or overweight who do not have diabetes. About 120 participants took either the drug or a placebo for around 8 months. The main goal was to measure changes in visceral fat (the …

This study tested a weight management program designed specifically for veterans with PTSD who are overweight or have obesity. The program adds extra support to standard PTSD care to help overcome PTSD-related challenges like stress eating or trouble staying active. 174 veterans …

This study tested a new medicine called CagriSema, a once-weekly injection, to help people with overweight or obesity and type 2 diabetes lose weight. About 1,200 adults received either CagriSema or a placebo for around 1.5 years. The main goals were to measure weight loss and ho…

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps people who are overweight or obese lose weight and improve their health. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, choles…

This study tested a program called Family Check-Up Heart, which helps new mothers and their babies improve heart health through home visits. About 117 low-income mothers in Allegheny County took part. The program focused on healthy weight, blood pressure, and lifestyle habits aft…

This study looked at whether sharing digital self-monitoring data (like weight, steps, and calories) with a friend or family member helps adults with overweight or obesity lose more weight over 24 months. About 320 adults used a wireless scale and Fitbit to track their progress. …

This study tested whether a probiotic called Weizmania Coagulans BC99 could improve gut bacteria and blood fat levels in overweight adults. 72 participants took either the probiotic or a placebo daily for 8 weeks. Researchers then checked changes in gut microbes and fat markers l…

This study tested a weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. 375 adults took part, some receiving the drug and others a placebo, along with lifestyle counseling. The main goal was to see how much weight they lost over 44 week…

This study looked at 226 adults who had lost at least 15% of their body weight using GLP-1 medications like Wegovy or Zepbound. Participants stopped their medication and were assigned different step-down treatments to see which helped maintain weight loss over 12 weeks. The main …

This study tested a culturally-tailored program that combines stress management, healthy eating, and exercise for African American women. 175 women with risk factors like high blood pressure or prediabetes took part. The goal was to see if the program could help them be more acti…

This early-stage study tested a new medicine (NNC0487-0111) for weight control in 36 Chinese adults with overweight or obesity. The main goal was to check the drug's safety and how it moves through the body. Participants received either the study drug or a placebo by injection, a…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study looked at whether whole-body vibration (standing on a vibrating platform) can help overweight and obese university students lose weight and improve body measurements like waist size and body fat. Thirty-two students took part. The goal was to see if this simple method …

This study looked at two weight loss programs for adults with overweight or obesity. One program told people to cut a fixed number of calories each day, while the other varied the calorie target. The goal was to see which approach helped people lose more weight.

This study tested a once-daily oral medication called orforglipron against a placebo in over 1,600 adults who are overweight or have obesity and also have type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants took t…

This early-stage study tested whether adding a new drug (LY3841136) to the existing weight-loss medication tirzepatide is safe and tolerable. It involved 96 healthy overweight or obese adults and lasted up to 42 weeks. The main goal was to check for side effects, not to measure w…

This study tested a weekly injection of semaglutide in 201 teenagers aged 12 to 17 with overweight or obesity. Participants received either the drug or a placebo for about 15 months, along with counseling on diet and exercise. The main goal was to see how much their body mass ind…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with excess body weight lose weight. 242 participants received either the drug or a placebo for about one year. The main goal was to see how much weight they lost and if at least 5% of body weight was red…

This study tested a once-weekly shot called tirzepatide to see if it helps people with obesity or overweight maintain weight loss they already achieved. About 441 adults who had lost weight during a 60-week diet period took either the drug or a placebo. The goal was to see if the…

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much weight they lost and if at least 5% of body we…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the tablet or a placebo for 44 weeks, along with guidance on healthy eating and physical activity. The main goals were to measure t…

This study tested a once-daily pill called orforglipron against insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had higher heart risk. The goal was to see if the pill is safe and effective at controlling blood sugar and preventing…

This study tested a program where community health workers visited families at home to help manage childhood obesity. It included 300 children aged 2-6 who were overweight. The goal was to see if this approach could lower their BMI over time.

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower blood sugar as effectively as standard programs led by human coaches. About 368 adults with prediabetes and overweight participated. The goal was to find a more ac…

This study tested whether an educational program for pregnant women who are overweight or obese could reduce the chance of their babies gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits during pregnancy. The goal…

This study tested a program to help pregnant women who are overweight or obese avoid gaining too much weight. It included 416 African American and Hispanic women in Philadelphia who were part of the WIC program. The program used text messages and guidance to support healthy eatin…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in people with treatment-resistant depression. 14 adults who were still depressed despite taking antidepressants were randomly given either omega-3 or a placebo for 12 weeks. Researchers mea…

This study tested a new medicine called NNC0662-0419 in 100 adults with overweight or obesity. The goal was to see if the drug is safe and how the body processes it. Participants received either the study drug or a placebo as an injection under the skin. This was the first time t…

This study tested a new drug called NNC0487-0111, given as a shot under the skin, to see if it is safe and how it works in people who are overweight or obese. 125 adults aged 18-55 with a BMI between 27 and 40 took part. The main goal was to check for side effects and measure how…

This study tested whether drinking herbal infusions of VitalPLANT and Helichrysum italicum for one week can improve weight and cholesterol in 30 overweight adults with metabolic syndrome. Participants drank either VitalPLANT alone or a mix of both herbs, with a washout period in …

This study looked at whether increasing everyday physical activity (like walking or standing) along with aerobic exercise improves heart health more than exercise alone in overweight young women. 28 women were split into two groups: one did only moderate aerobic exercise, and the…

This early-stage study tested a single dose of the investigational drug eloralintide in 30 Chinese adults who are overweight or have obesity. The main goal was to check safety and side effects, and to see how the drug moves through the body. Participants were monitored for about …

This early-stage study tested the safety and tolerability of a new drug called eloralintide, given alone or with another drug (tirzepatide), in 188 adults with overweight or obesity. Participants received weekly injections under the skin, and researchers monitored side effects an…

This study checked whether survodutide, a new medicine for weight loss, causes any heart rhythm problems. About 110 adults with overweight or obesity received weekly injections of survodutide or a placebo for 30 weeks, along with occasional heart monitoring. The main goal was to …

This study looked at how a combination medicine called CagriSema affects appetite and brain activity in people who are overweight or have obesity. About 164 participants took part, some receiving the medicine and others a placebo. The goal was to understand how the drug changes f…

This study tested a once-weekly medicine called retatrutide in 445 adults who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it can reduce knee pain and help with weight loss compared to a placebo. The trial lasted about 77 weeks and meas…

This study tested the safety and side effects of a new drug called LY3841136, given alone or with another drug (tirzepatide), in 128 Japanese adults with obesity or overweight. Participants were monitored for about 28 to 40 weeks through blood tests and checkups. The goal was to …

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Vietnam. The program included lessons, videos, and activities to improve diet and exercise. Researchers compared these children to a control group to see if the program improved …

This study looked at how well a healthy lifestyle program called Deaf Weight Wise works when run by community organizations for Deaf adults who use American Sign Language. 85 Deaf adults from New York took part. The goal was to see if local groups could successfully deliver the p…

This study looked at health records from over 887,000 people with type 2 diabetes and overweight to compare two drugs—tirzepatide and semaglutide—for preventing heart attacks, strokes, or death. The goal was not to test a new treatment but to see if analyzing real-world data can …

This study looked at whether it is possible to add a nutrition program called BfedBwell to an existing exercise program for cancer survivors. Twenty adults who had finished cancer treatment and were overweight or obese took part. The goal was to see if the program was easy to fol…

This early-stage study looked at how the experimental drug HU6 behaves in the bodies of 59 overweight adults. Participants took different forms (tablets or capsules) and doses of HU6, and researchers measured drug levels and checked for side effects. The goal was to gather safety…

This study looked at whether a new weight-loss drug (BI 456906) changes how the body processes three common drugs: bupropion, caffeine, and midazolam. It involved 34 healthy adults with overweight or obesity. Participants took the three drugs alone, then again while receiving wee…

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease and death rates. Researchers used national survey information from 2013, 2018, and 2023. No treatments were given—the goal was simply to understand the pro…

This study looked at how a single session of walking or jogging changes appetite-related hormones and brain activity in 40 adults who were either normal weight or overweight/obese. Researchers measured hormone levels in blood and used brain scans to see how participants responded…

This study tested whether sending specific text messages at just the right moments helps young adults with overweight or obesity meet their daily weight, activity, and diet goals. 255 participants used a mobile weight loss program and received either a message or no message at ra…

This study follows people who were in the SELECT trial for an anti-obesity medication. It does not provide any new treatment—instead, participants fill out health questionnaires every 6 months for up to 10 years. The goal is to see long-term effects like heart attacks, strokes, c…

This study aimed to uncover the genetic and lifestyle factors that cause pre-diabetes to turn into type 2 diabetes. Over 1,700 healthy adults aged 18 to 55 underwent detailed tests of how their bodies handle sugar and store fat. Researchers hope these findings will lead to better…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This study looked at why some people become obese by examining eating behaviors and food preferences, especially for high-fat foods. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake m…

This study looked at how an experimental drug for obesity (HRS-7535) interacts with four common medicines: acetaminophen (pain relief), digoxin (heart medication), rosuvastatin (cholesterol), and omeprazole (acid reflux). It involved 40 overweight or obese adults and measured dru…

This early-stage study looked at how a low-fat meal and taking the drug in the evening change the way KAI-7535 moves through the body. It involved 18 healthy adults who were overweight or obese. The goal was to gather information for future dosing instructions, not to treat or cu…

This study followed 200 children and young adults who are overweight or have obesity and are at risk for high blood pressure. Researchers collected medical information over time to learn how excess weight affects the heart and blood vessels. The goal is to better understand these…

This study looked at how a short, intense exercise test affects blood sugar, fats, inflammation, and other health markers in 35 teenage girls. Half were normal weight and half were overweight or obese. The goal was simply to measure and compare these changes, not to treat or cure…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutrition advice and physical activity. The goal was to identify barriers and motivators so future programs can be more effective. R…

This study looked at how type 2 diabetes works in children and young adults aged 12 to 25. Researchers gave some participants insulin shots to give their pancreas a rest and checked if that helped insulin production. They also compared diabetic and non-diabetic volunteers to lear…

This study looked at how eating beans changes the way the body uses fat, carbohydrates, and protein for energy. Thirty-six overweight adults ate meals with whole beans or bean flour, and researchers measured their energy use in a special room. The goal was simply to learn more, n…

This study looked at how the experimental drug GZR18 is processed by the body in 6 overweight or obese Chinese men. Participants took a single dose, and researchers measured the drug and its breakdown products in blood, urine, and feces over 78 days. The goal was to understand ho…

This study tested whether a medical body composition scale (mBCA 555) could detect early improvements in health—like changes in muscle, fat, or water balance—in 41 overweight adults using L112 weight-loss products. The goal was to find signs of progress that appear before the sca…

This study looked at whether a 2014 Danish law requiring 45 minutes of daily physical activity in public schools actually increased kids' activity and helped with weight. Researchers measured movement and BMI in over 5,000 children before and after the reform. The goal was to see…

This study looked at how an anti-nausea drug (ondansetron) affects the levels of an experimental weight-loss medication (AMG 133) in the blood. It involved 59 adults who were overweight or obese. The goal was to gather information on drug interactions, not to treat or cure obesit…

This early-stage study tested a single dose of an experimental drug called SAR441255 in 48 healthy adults who were lean to overweight. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at its effects on blood sugar and insulin lev…

This early-stage study tested a single dose of a new medicine, NNC0662-0419, in 100 adults with overweight or obesity. Researchers wanted to see how the drug behaves in the body and whether it is safe in Japanese, Chinese, and non-Asian participants. The study lasted up to 2 mont…

This study looked at how giving parents health information changes the food choices they make for their young children. Over 1,100 mothers and fathers of kids ages 3-7 answered online surveys and used a virtual reality buffet to pick a meal for their child. The goal was to unders…