OVERWEIGHT

This study tested whether a weekly injection called semaglutide could help teenagers with overweight or obesity manage their weight. Over 200 teens received either the real medication or a placebo (dummy shot) for about 15 months, along with counseling on healthy eating and activ…

This study tested whether a natural plant supplement called enzymatically modified isoquercitrin (EMIQ) could safely help reduce body fat in overweight and obese adults. Sixty-five participants took either the supplement or a placebo for 12 weeks while researchers measured body f…

This early-stage study tested an experimental drug called AMG 133, given as injections under the skin, in 120 adults who are overweight or have obesity. The main goal was to understand how the drug moves through and stays in the body after multiple doses. Researchers also closely…

This study tested whether a new injectable medication called GZR18 could help people with obesity or overweight lose weight. It involved 340 Chinese adults who received either the real injection or a placebo (dummy shot) for 30 weeks. Researchers measured changes in body weight a…

This study tested a weekly injection called LY3437943 (retatrutide) in people who are overweight or have obesity and also have painful knee osteoarthritis. The main goals were to see if the treatment safely reduced knee pain and helped participants lose weight over about 77 weeks…

This study tested whether taking a daily omega-3 supplement from algae could help improve blood fat (triglyceride) levels and reduce inflammation in overweight and obese adults in Chile who have high triglycerides. Forty participants took either the omega-3 pill or a placebo oil …

This study tested which of two diet coaching methods works better for weight loss. Over 200 overweight adults followed a program that either gave them a fixed daily calorie goal or a goal that changed from day to day. Researchers measured weight loss, body composition, and how pa…

This large, late-stage study tested a once-daily oral medication called LY3502970 (orforglipron) to see if it could help people lose weight and better manage their type 2 diabetes. Over 1,600 adults with obesity or overweight and type 2 diabetes participated, comparing the drug t…

This early-stage study tested the safety and effects of a new drug called LY3841136, both by itself and combined with the existing weight-loss medication tirzepatide. It involved 128 Japanese adults who were living with obesity or overweight. The main goals were to check for side…

This study tested if sharing daily health data helps people maintain weight loss. Over 300 adults with overweight or obesity followed a 2-year lifestyle program. They tracked their weight, activity, and food, and researchers tested if sharing this data with a coach, a support gro…

This study tested whether an online family support program could work well alongside a standard weight loss program for Black adults. Researchers wanted to see if adding family skills training online would be practical and acceptable to participants. The program focused on improv…

This study tested whether a daily pill called oral semaglutide could help adults with overweight or obesity lose weight. Over 300 participants took either the real pill or a placebo (a dummy pill) for 64 weeks. Researchers measured how much weight people lost and whether it impro…

This early-stage study tested the safety and side effects of a single dose of eloralintide, an experimental weight management drug, in 30 Chinese adults with obesity or overweight. Researchers monitored participants for 10 weeks to see how their bodies handled the medication and …

This study tested whether a new weight-loss medicine called survodutide (BI 456906) is safe for the heart. It involved 110 otherwise healthy adults with overweight or obesity who received weekly injections for about 30 weeks. Researchers closely monitored participants' heart rhyt…

This study tested whether a weekly injection called survodutide helps adults in China with overweight or obesity lose weight. Over 300 participants were randomly assigned to receive one of two doses of the drug or a placebo injection for about 19 months. Researchers measured chan…

This study tested a culturally tailored program designed to help African American women manage stress, improve their diet, and increase physical activity. The goal was to see if this approach could lower their risk for heart disease, stroke, and diabetes. 175 women who were overw…

This study tested whether a weekly injection called semaglutide helps adults with overweight or obesity lose weight. About 240 participants were randomly assigned to receive either the real medication or a placebo (dummy injection) for one year. Researchers measured how much weig…

This study tested whether an experimental drug called AMG 133 could help people lose weight and keep it off for a year. Nearly 600 adults with obesity, some of whom also had type 2 diabetes, received either the drug or a placebo injection. Researchers measured how much weight par…

This study tested whether a daily pill called orforglipron helps people maintain weight they had already lost in a previous trial. It involved 376 adults with obesity or overweight who had weight-related health issues. Participants were randomly assigned to receive either the act…

This study tested a school-based program to help overweight and obese teenagers manage their weight. It aimed to see if providing extra support—like motivational interviews, cooking classes, and activity funding—to teens from less advantaged backgrounds could give them the same b…

This study tested whether a daily oral tablet called semaglutide could help Chinese adults with overweight or obesity lose weight. For about one year, 200 participants took either the real pill or a placebo, alongside counseling on healthy eating and physical activity. The main g…

This study tested an investigational drug called CT-868 to see if it could help lower blood sugar and reduce body weight in adults with type 2 diabetes who are also overweight or obese. Over 100 participants received either the drug or a placebo for 26 weeks. The main goal was to…

This study tested the safety of combining two weight management drugs, tirzepatide and a new drug called LY3841136, in overweight and obese adults. It involved 96 participants and lasted about 42 weeks. The main goal was to see if the combination was safe and well-tolerated, whil…

This study tested whether a higher dose of a daily oral medication (semaglutide 50 mg) could help adults with overweight or obesity lose weight. Over 660 participants were randomly assigned to take either the active pill or a placebo (dummy pill) for 68 weeks, alongside lifestyle…

This study tested how well community organizations could run a healthy lifestyle program for Deaf adults who use American Sign Language. Researchers worked with 85 adults in New York to see if local groups could successfully lead the program, which focused on diet and exercise. T…

This study tested the safety of a new weight control injection called NNC0487-0111 in Chinese men with overweight or obesity. For about 53 days, 36 participants received either the real injection or a placebo (dummy shot) to see how their bodies reacted. The main goal was to chec…

This study tested a new weekly injection called CagriSema to see if it helps people with obesity and type 2 diabetes lose weight and better control their blood sugar. About 1,200 participants were randomly assigned to receive either the real medicine or a placebo (dummy medicine)…

This study tested whether drinking two different herbal tea blends could improve health markers in adults with metabolic syndrome. Thirty overweight adults drank either a 'VitalPLANT' tea or a combination of VitalPLANT and Helichrysum italicum tea daily for one week. Researchers …

This early-stage study tested how a new drug called orforglipron changes body fat, especially deep belly fat, in adults with obesity or overweight who do not have diabetes. It compared the drug's effects to a placebo (inactive substance) in 120 participants over about 8 months. T…

This early-stage study tested the safety and how the body processes two experimental drugs, eloralintide alone and combined with tirzepatide, for weight management. It involved 188 adults who were overweight or obese, giving weekly injections under the skin for up to 26 weeks. Re…

This study tested how a new weight-loss medicine called CagriSema affects people's appetite, food cravings, and brain activity. It involved 164 adults with overweight or obesity, comparing those who received the medicine to those who received a dummy treatment. Researchers used q…

This study tested a new weekly injection called CT-388 to see if it helps people with obesity or overweight lose weight and improve related health measures. Nearly 470 adults received either the drug or a placebo (dummy injection) for 48 weeks. The main goal was to measure the pe…

This study directly compared two injectable medications, tirzepatide and semaglutide, to see which one helps people lose more weight. It involved 751 adults who had obesity or were overweight with related health problems like high blood pressure, but who did not have diabetes. Th…

This study tested the safety of a new injectable medication called NNC0662-0419 for people with overweight or obesity. It was the first time this experimental drug was given to humans. Researchers monitored 100 participants for about 9 months to see how their bodies handled the m…

This study tested whether sending specific, well-timed messages through a phone app could help young adults with overweight or obesity stick to daily weight loss behaviors. Over 200 participants used an app with lessons, tracking, and daily goals for weighing, activity, and food.…

This study tested whether a new weekly injection called semaglutide could help people with overweight or obesity manage their weight. About 375 participants were randomly assigned to receive either the real injection or a placebo for about a year, alongside lifestyle counseling. …

This study tested whether a specific probiotic strain, Weizmania Coagulans BC99, could improve gut bacteria and key blood markers related to fat metabolism (like cholesterol and triglycerides) in overweight adults. For 8 weeks, 72 participants were randomly assigned to take eithe…

This study tested whether an 8-week exercise program could improve health markers in overweight young women. Twenty-two participants either followed a circuit workout plan or continued their usual activities. The results suggest the exercise program increased a beneficial hormone…

This study tested whether using a whole-body vibration machine could help overweight university students manage their weight and body composition. Researchers randomly assigned 32 students to either use the vibration platform or not, then measured changes in their body mass index…

This study tested a new injectable drug called NNC0487-0111 to see if it is safe and helps with weight loss in people with overweight or obesity. It involved 125 adults who received either the drug or a placebo (dummy) injection. The main goals were to check for side effects and …

This small pilot study tested whether adding a nutrition program (BfedBwell) to an existing exercise program (BfitBwell) is practical and acceptable for cancer survivors. It involved 20 survivors who were overweight and had finished active cancer treatment. The main goal was to s…

This large, completed study looked back at health records of over 285,000 overweight or obese adults to see if taking the weekly medication semaglutide was linked to fewer serious heart problems. It focused on three groups: people with existing heart failure, people with heart ar…

This early-stage study tested how a common anti-nausea medicine (ondansetron) affects the way the body processes a new weight management drug called AMG 133. It involved 59 adults who were overweight or had obesity. The main goal was to check if taking the two drugs together chan…

This study tested if adding more daily movement to a regular exercise routine improves heart health more than exercise alone. Researchers compared two groups of overweight young women over 8 weeks: one group did aerobic exercise, while the other group also tried to reduce sitting…

This study tested a program to help prevent excessive weight gain during pregnancy for women who are overweight or have obesity. The program was delivered through local WIC clinics and used text message reminders, personalized feedback, and nutrition counseling. Researchers wante…

This study tested whether providing education about healthy eating and modest exercise to overweight or obese pregnant women could help prevent rapid weight gain in their children during the first two years of life. Researchers compared women who received this special education p…

This study tested whether a family-centered program led by community health workers could help prevent obesity in young children. The program involved home visits, text messaging, and coaching on healthy eating and activity for 300 families with children aged 2-6 who were overwei…

This study tested a new home-visit program designed to help new mothers improve their heart health. The program, called Family Check-Up Heart, provided 117 low-income mothers with coaching on diet, exercise, and stress management. Researchers compared it to a standard home-visit …

This study tested whether a fully automated smartphone app could be as effective as a traditional human coach program at helping people with prediabetes lower their risk of developing type 2 diabetes. 368 adults were randomly assigned to use either the app with a smart scale or a…

This study aimed to understand if giving parents health information changes the food choices they make for their children. Over 1,100 parents used a virtual reality buffet to pick a lunch for their child before and after watching a health presentation. Researchers measured if the…

This study follows 3,439 people for up to 10 years after they completed a weight-loss medication trial. Participants fill out health questionnaires every 6 months to track long-term outcomes like weight changes, heart health, diabetes risk, and quality of life. No medication or t…

This early-stage study tested a single dose of an experimental weight management medicine called NNC0662-0419. Researchers enrolled 100 Japanese, Chinese, and non-Asian adults with overweight or obesity to measure how much medicine appeared in their blood and check for side effec…

This study created a registry to track the long-term heart health of children and young adults who are overweight or obese and have high blood pressure. Researchers collected health information from about 200 participants over time through their regular clinic visits. The goal wa…

This early-stage study tested the safety of an experimental drug called GUB014295 in healthy but overweight adults. Researchers gave single and multiple doses to 76 participants to see how their bodies reacted and processed the medication. The main goal was to check for side effe…

This study looked at whether eating a meal with beans changes how the body uses food for fuel. Researchers tested 36 healthy adults to see if bean-based meals made the body burn more fat for energy compared to other meals with similar calories. The goal was to understand how natu…

This study aimed to better understand how type 2 diabetes develops and progresses in children, teenagers, and young adults. Researchers compared 82 young people with diabetes to healthy peers, measuring how their bodies process sugar, store fat, and handle exercise. The goal was …

This study aimed to understand how the body absorbs, breaks down, and eliminates a single dose of an experimental drug called GZR18. It involved 6 Chinese men who were overweight or obese. Researchers tracked the drug's path by measuring it in blood, urine, and feces over several…

This study looked at how being overweight or obese affects heart disease rates and risk factors in Chinese adults. Researchers analyzed existing health survey and death records from over 550,000 people to understand the link between weight and heart health. The goal was to measur…

This was the first study in humans to test the safety and body's response to a new drug called SAR441255. It involved 48 healthy to slightly overweight adults who received a single injection. The main goal was to see if it was safe and to measure how it affected blood sugar and i…

This study aimed to understand how a single hour of walking or jogging affects the body's natural appetite signals and brain activity. Researchers measured hormone levels, food intake, and brain scans in 40 people of different body weights after exercise and at rest. The goal was…

This study aimed to understand if a new injectable drug for weight management (BI 456906/Survodutide) changes how the body processes three common substances: caffeine, a sleep aid (midazolam), and an antidepressant (bupropion). It involved 34 otherwise healthy adults with overwei…

This was an early, small study to see how the body processes different pill versions of an experimental drug called HU6 and to check if it is safe. It involved 59 overweight adults who took various doses and forms of the drug, either with or without food. The main goal was to und…

This study analyzed health insurance records of nearly 900,000 people to compare how well different diabetes and weight management drugs protect against serious heart problems. It specifically looked at tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic/Wegovy) versus other…

This study aimed to understand why some people develop type 2 diabetes by looking at genetic and environmental factors. Researchers enrolled 1,759 adults to measure their body composition, insulin function, and glucose tolerance, and collected tissue and DNA samples. The goal was…

This study aimed to understand how a single, exhausting workout affects the body differently in normal-weight and overweight/obese teenage girls. Researchers had 35 girls perform a tough, progressive running test until they were exhausted. They took blood samples before, right af…

This study aimed to understand how eating behaviors and food preferences, particularly for high-fat foods, might contribute to obesity. Researchers compared 669 healthy adults from Pima Indian and Caucasian backgrounds using questionnaires and measurements of food intake. The goa…

This study aimed to understand how a low-fat meal and taking a drug in the evening affect how the body absorbs and processes a new drug called KAI-7535. It involved 18 healthy adults who were living with obesity or overweight. The main goal was to gather basic safety and drug-lev…

The main purpose of this study is to evaluate the efficacy and safety of tirzepatide for the maintenance of body weight reduction.