Weight loss drug showdown: which works better?

NCT ID NCT05822830

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 3 trial tested two injectable weight loss drugs, tirzepatide and semaglutide, in 751 adults with obesity or overweight who also had weight-related health problems like high blood pressure. The study lasted about 74 weeks and measured how much weight participants lost. The goal was to see which drug works better for weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide and semaglutide (injectable weight loss drugs)
What this could lead to: If tirzepatide proves more effective than semaglutide, it could offer a better option for significant weight loss in people with obesity or overweight.
What could go wrong: This is a completed phase 3 trial, but results may not apply to everyone. Both drugs can cause side effects like nausea or vomiting, and weight regain is possible after stopping.

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Conditions

The condition(s) this trial relates to.

disease Motor Activity Obesity obesity disorder Overweight prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Alliance for Multispecialty Research, LLC

Norman, Oklahoma, 73069, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, 48098, United States
Biopharma Informatic, LLC

Houston, Texas, 77043, United States
Cahaba Research

Birmingham, Alabama, 35242, United States
Cahaba Research - Pelham

Pelham, Alabama, 35124, United States
Dallas Diabetes Research Center

Dallas, Texas, 75230, United States
Encompass Clinical Research

Spring Valley, California, 91978, United States
ForCare Clinical Research

Tampa, Florida, 33613-1244, United States
Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa, 50265, United States
L-MARC Research Center

Louisville, Kentucky, 40213, United States
Lillestol Research

Fargo, North Dakota, 58104, United States
New Horizon Research Center

Miami, Florida, 33165, United States
North Texas Endocrine Center

Dallas, Texas, 75231, United States
Palm Research Center Sunset

Las Vegas, Nevada, 89148, United States
Palm Research Center Tenaya

Las Vegas, Nevada, 89128, United States
PharmQuest

Greensboro, North Carolina, 27408, United States
Pinnacle Clinical Research

San Antonio, Texas, 78229, United States
PlanIt Research, PLLC

Houston, Texas, 77079, United States
Prime Health and Wellness/SKYCRNG

Fayette, Mississippi, 39069, United States
Puerto Rico Medical Research

Ponce, 00717, Puerto Rico
Rocky Mountain Clinical Research

Idaho Falls, Idaho, 83404, United States
Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, 30291, United States
Southern California Dermatology, Inc.

Santa Ana, California, 92701, United States
Southern Endocrinology Associates

Mesquite, Texas, 75149, United States
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
The University of Texas Health Science Center at Houston

Bellaire, Texas, 77401, United States
Tribe Clinical Research, LLC

Greenville, South Carolina, 29607, United States
University Clinical Investigators, Inc.

Tustin, California, 92780, United States
Velocity Clinical Research, Hallandale Beach

Hallandale, Florida, 33009, United States
WR-Clinsearch, LLC

Chattanooga, Tennessee, 37421, United States
Weill Cornell Medical College

New York, New York, 10021, United States
Wellness clinical Research Vega Baja

Vega Baja, 00694, Puerto Rico

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