Weight-Loss drug showdown: which one wins?

NCT ID NCT05822830

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jan 09, 2026 · Last updated Apr 25, 2026 · Updated 13 times

Summary

This study tested two weight-loss medications, tirzepatide and semaglutide, in 751 adults with obesity or overweight who also had related health problems like high blood pressure. Participants did not have diabetes. The trial lasted about 74 weeks and measured how much weight people lost and how many achieved significant weight loss (10% or more). The goal was to see which drug works better and is safer for long-term weight management.

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Contacts and locations

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Locations

Alliance for Multispecialty Research, LLC

Norman, Oklahoma, 73069, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, 48098, United States
Biopharma Informatic, LLC

Houston, Texas, 77043, United States
Cahaba Research

Birmingham, Alabama, 35242, United States
Cahaba Research - Pelham

Pelham, Alabama, 35124, United States
Dallas Diabetes Research Center

Dallas, Texas, 75230, United States
Encompass Clinical Research

Spring Valley, California, 91978, United States
ForCare Clinical Research

Tampa, Florida, 33613-1244, United States
Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa, 50265, United States
L-MARC Research Center

Louisville, Kentucky, 40213, United States
Lillestol Research

Fargo, North Dakota, 58104, United States
New Horizon Research Center

Miami, Florida, 33165, United States
North Texas Endocrine Center

Dallas, Texas, 75231, United States
Palm Research Center Sunset

Las Vegas, Nevada, 89148, United States
Palm Research Center Tenaya

Las Vegas, Nevada, 89128, United States
PharmQuest

Greensboro, North Carolina, 27408, United States
Pinnacle Clinical Research

San Antonio, Texas, 78229, United States
PlanIt Research, PLLC

Houston, Texas, 77079, United States
Prime Health and Wellness/SKYCRNG

Fayette, Mississippi, 39069, United States
Puerto Rico Medical Research

Ponce, 00717, Puerto Rico
Rocky Mountain Clinical Research

Idaho Falls, Idaho, 83404, United States
Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, 30291, United States
Southern California Dermatology, Inc.

Santa Ana, California, 92701, United States
Southern Endocrinology Associates

Mesquite, Texas, 75149, United States
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
The University of Texas Health Science Center at Houston

Bellaire, Texas, 77401, United States
Tribe Clinical Research, LLC

Greenville, South Carolina, 29607, United States
University Clinical Investigators, Inc.

Tustin, California, 92780, United States
Velocity Clinical Research, Hallandale Beach

Hallandale, Florida, 33009, United States
WR-Clinsearch, LLC

Chattanooga, Tennessee, 37421, United States
Weill Cornell Medical College

New York, New York, 10021, United States
Wellness clinical Research Vega Baja

Vega Baja, 00694, Puerto Rico

Conditions

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