New pill form of Weight-Loss drug could offer same benefits as capsules

NCT ID NCT06440980

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether orforglipron, an experimental oral drug for weight management, works the same when given as a tablet versus a capsule. Healthy adults with a BMI between 27 and 40 take the drug for about 22 to 25 weeks, and researchers measure how much of the drug enters the bloodstream and how quickly the body clears it. The goal is to see if the tablet form can be used instead of capsules without changing the drug's effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: orforglipron (LY3502970), an oral drug
What this could lead to: If successful, this study could confirm that orforglipron tablets work the same as capsules, potentially leading to a more convenient treatment option for weight management.
What could go wrong: This is an early-phase trial focused on drug absorption, not weight loss. The results may not predict long-term effectiveness or safety, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY OBESE OBESITY OVERWEIGHT

Contacts and locations

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Locations

Altasciences Company Inc.

Overland Park, Kansas, 66212, United States
Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States
Collaborative Neuroscience Research, LLC

Los Alamitos, California, 90720, United States
Fortrea Clinical Research Unit

Daytona Beach, Florida, 32117, United States
Fortrea Clinical Research Unit

Dallas, Texas, 75247, United States
Fortrea Clinical Research Unit

Madison, Wisconsin, 53704, United States
QPS

Springfield, Missouri, 65802, United States

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