New weekly shot shows promise for major weight loss

NCT ID NCT06525935

Completed Disease control Sponsor: Carmot Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called enicepatide (CT-388) given as a weekly injection for 48 weeks. It involved 469 adults with obesity or overweight who also had at least one weight-related health problem like high blood pressure or prediabetes. The goal was to see how much weight people lost and whether the drug was safe and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enicepatide (also called CT-388), a once-weekly injectable drug
What this could lead to: If successful, this could lead to a new weekly injection for significant weight loss in people with obesity or overweight and related health issues.
What could go wrong: This is a Phase 2 dose-finding study, so results are still early. The drug may cause side effects or fail to show enough benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Alabama Clinical Therapeutics, LLC

Birmingham, Alabama, 35235, United States
Alliance for Multispecialty Research, LLC

Knoxville, Tennessee, 37920, United States
Amicis Research Center

Northridge, California, 91324, United States
Amicis Research Center - Anaheim

Anaheim, California, 92801, United States
Amicis Research Center - West Hills

West Hills, California, 91307, United States
Apex Mobile Clinical Research

Bellaire, Texas, 77401, United States
Ark Clinical Research - Long Beach

Long Beach, California, 90806, United States
Ark Clinical-Fountain Valley

Fountain Valley, California, 92708, United States
Central Alabama Research

Homewood, Alabama, 35209, United States
Chrysalis Clinical Research

St. George, Utah, 84790, United States
Clinical Research Associates, Inc.

Nashville, Tennessee, 37203, United States
Elevate Clinical

Seabrook, Texas, 77586, United States
FutureSearch Trials of Dallas, LLC

Dallas, Texas, 75231, United States
Impact Research Institute

Waco, Texas, 76710, United States
Infinity Clinical Research

Norco, California, 92860, United States
Louisville Metabolic and Atherosclerosis Research Center (L-MARC)

Louisville, Kentucky, 40213, United States
Lucas Research, Inc

Morehead City, North Carolina, 28557, United States
Mercury Street Medical Group

Butte, Montana, 59701, United States
National Clinical Research - Richmond, Inc

Richmond, Virginia, 23294, United States
Neurobehavioral Research, Inc. (NBR)

Cedarhurst, New York, 11516, United States
Orange County Research Center

Tustin, California, 92780, United States
Pinnacle Clinical Research

San Antonio, Texas, 78229, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
Prospective Research Innovations Inc.

Rancho Cucamonga, California, 91730, United States
Tampa Bay Medical Research, Inc.

Clearwater, Florida, 33761, United States
Texas Diabetes & Endocrinology, P.A.

Austin, Texas, 78731, United States
The Center for Pharmaceutical Research

Kansas City, Missouri, 64114, United States
The Institute for Liver Health II LLC dba Arizona Clinical Trials; Arizona Liver Health

Mesa, Arizona, 85210, United States
Tribe Clinical Research

Greenville, South Carolina, 29607, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
Velocity Clinical Research - Cincinnati

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research - Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research - Los Angeles

Los Angeles, California, 90057, United States
Velocity Clinical Research, Providence

East Greenwich, Rhode Island, 02818, United States

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