Weight loss pill shows promise: daily semaglutide helps shed pounds

NCT ID NCT05035095

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a daily oral semaglutide tablet (50 mg) for weight loss in 667 adults with overweight or obesity. Participants took the pill or a placebo for 68 weeks, along with diet and exercise advice. The main goals were to measure percentage weight loss and how many people lost at least 5% of their body weight.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide tablets
What this could lead to: If successful, this could provide a convenient daily pill option for significant weight loss in people with overweight or obesity.
What could go wrong: This is a completed Phase 3 trial, but results may not apply to everyone. Side effects like nausea or vomiting are possible, and long-term safety is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Accellacare

Wilmington, North Carolina, 28401, United States
Capital Clin Res Ctr,LLC

Olympia, Washington, 98502, United States
Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque-2

Pessac, 33600, France
Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec

Saint-Herblain, 44800, France
Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-2

Toulouse, 31054, France
Centre de Recherche Clinique Portes Du Sud

Vénissieux, 69200, France
Centrum Medyczne Pratia Gdynia

Gdynia, Pomeranian Voivodeship, 81-338, Poland
Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.

Lodz, 90-338, Poland
Centrum Zdrowia Metabolicznego Paweł Bogdański

Poznan, Wielkopolskie Voivodeship, 60-589, Poland
Chiba University Hospital_Diabetes, Metabolism and Endocrinology

Chiba-shi, Chiba, 260-8677, Japan
Clinical Trial Res Assoc,Inc

Plantation, Florida, 33324, United States
Diabetes Zentrum Wandsbek Berufsausuebungsgemeinschaft GbR

Hamburg, 22041, Germany
Dr. Milek medikum

Hohenmölsen, 06679, Germany
East West Med Res Inst

Honolulu, Hawaii, 96814, United States
Endocrinological Dispensary of Department of healthcare ser.

Moscow, 119034, Russia
FSBI 'I.I. Dedov National Medical Research Center of Endocrinology' of the MH of Russia

Moscow, 117292, Russia
Federal Bureau for Medical and Social Expertise

Moscow, 127486, Russia
Fondation Hôtel-Dieu

Le Creusot, 71200, France
G.A. Research Associates Ltd.

Moncton, New Brunswick, E1G 1A7, Canada
Gabinet Leczenia Otylosci i Chorob Dietozaleznych

Bialystok, Podlaskie Voivodeship, 15-281, Poland
Gentofte Hospital - Center for Klinisk Metabolisk Forskning

Hellerup, 2900, Denmark
Groupe Sos Sante-Hopital Le Creusot-Hotel Dieu-2

Le Creusot, 71200, France
Higashi-shinjuku clinic

Tokyo, 169-0072, Japan
Hvidovre Hospital Endokrinologisk forsknings afsnit 159

Hvidovre, 2650, Denmark
InnoDiab Forschung GmbH

Essen, 45136, Germany
Joint Stock Company "Medical technologies"

Yekaterinburg, 620075, Russia
Joint Stock Company "Polyclinic Complex"

Saint Petersburg, 190013, Russia
LLC "Clinic of new technologies in Medicine"

Dzerzhinskiy, 140091, Russia
Leningrad Regional Clinical Hospital

Saint Petersburg, 194291, Russia
Les Hopitaux de Chartres-Hopital Louis Pasteur

Le Coudray, 28630, France
MZM Praxis Drs. Erlinger

Stuttgart, 70378, Germany
Midwest Inst For Clin Res

Indianapolis, Indiana, 46260, United States
NZOZ Przychodnia Specjalistyczna Medica

Lublin, Lubelski, 20-538, Poland
Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 1V7, Canada
Obesity Research Unit

Helsinki, 00014, Finland
Ocean West Research Clinic

Surrey, British Columbia, V3Z 2N6, Canada
Praxis Dr. med. M. Esser

Essen, 45219, Germany
Praxis Dr. med. Wenzl-Bauer

Rehlingen-Siersburg, 66780, Germany
Premier Clinical Trial Research Network (PCTRN)

Hamilton, Ontario, L8M 1K7, Canada
RED-Institut für medizinische Forschung und Fortbildung GmbH

Oldenburg in Holstein, 23758, Germany
Rochester Clinical Research, Inc.

Rochester, New York, 14609, United States
Seinäjoen keskussairaala

Seinäjoki, 60220, Finland
Selma Medical Associates

Winchester, Virginia, 22601-3834, United States
Sjællands Universitetshospital, Køge - Medicinsk Afdeling

Køge, Region Sjælland, 4600, Denmark
Slagelse Sygehus Ambulatorium for hjertesygdomme

Slagelse, 4200, Denmark
StudyCor

Jyväskylä, 40620, Finland
Suidoubashi Medical Clinic_Internal Medicine

Chiyoda-ku, Tokyo, 101-0065, Japan
The Chappel Group Research

Kissimmee, Florida, 34744, United States
The University of Penn Center

Philadelphia, Pennsylvania, 19104-3317, United States
Tumen State Medical University

Tyumen, Russia, 625023, Russia
Univ of Alabama Birmingham

Birmingham, Alabama, 35233, United States
Velocity Clin Res Los Angeles

Los Angeles, California, 90017, United States
Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States
Washington Cntr Weight Mgmt

Arlington, Virginia, 22206, United States
Wharton Medical Clinic Clinical Trials (Hamilton)

Hamilton, Ontario, L8L 5G8, Canada
Zentrum für klinische Studien Allgäu Oberschwaben

Wangen, 88239, Germany

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