What happens when you stop Weight-Loss shots? new study tests backup plans
NCT ID NCT06605703
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study looked at 226 adults who had lost at least 15% of their body weight while taking GLP-1 medications like Wegovy or Ozempic. Participants stopped their GLP-1 drug and were given either bupropion-naltrexone or bupropion-naltrexone-metformin, plus behavioral support through a telehealth platform. The main goal was to see how much weight they regained or lost after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Bupropion-Naltrexone and Bupropion-Naltrexone-Metformin
What this could lead to
If successful, this could point toward effective options to maintain weight loss after stopping popular GLP-1 medications like Wegovy or Ozempic.
What could go wrong
This is a small, 12-week completed trial with 226 participants, so results may not apply to everyone. The step-down drugs have their own side effects and may not fully prevent weight regain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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WW International, Inc
New York, New York, 10011, United States