100,000-Person study pits Weight-Loss drugs against heart attacks

NCT ID NCT07619508

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study compares two popular weight-loss medications, tirzepatide and semaglutide, in 100,000 adults who are overweight or obese and at risk for heart problems but do not have diabetes. Researchers are analyzing real-world data to see which drug better prevents death, heart attacks, or strokes. The goal is to guide doctors in choosing the best treatment for heart health.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02120, United States