Weekly injection helps shed pounds in major weight loss trial

NCT ID NCT04251156

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over 44 weeks. Results showed significant weight reduction, making it a promising option for long-term weight management.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 OBESITY OVERWEIGHT

Contacts and locations

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Locations

Ajou University Hospital

Gyeonggi-do, 16499, South Korea
Beijing Luhe Hospital Capital Medical University

Beijing, Beijing Municipality, 101100, China
Beijing Pinggu Hospital-Endocrinology

Beijing, Beijing Municipality, 101200, China
CPCLIN - Centro de Pesquisas Clínicas

São Paulo, São Paulo, 01228-200, Brazil
Cangzhou People's Hospital

Cangzhou, Hebei, 061000, China
Cangzhou People's Hospital-Endocrinology

Cangzhou, Hebei, 061000, China
Changzhou No.2 People's Hospital, Yanghu Branch

Changzhou, Jiangsu, 213003, China
Chinese People's Liberation Army General Hospital-Endocrinology

Beijing, Beijing Municipality, 100853, China
Chongqing University Three Gorges Hospital

Chongqing, Chongqing Municipality, 404000, China
Fujian Medical University Union Hospital-Endocrinology

Fuzhou, Fujian, 350001, China
General Hospital of Tianjin Medical University-Endocrinology

Tianjin, Tianjin Municipality, 300052, China
Harrison International Peace Hospital-Endocrinology

Hengshui, Hebei, 053000, China
Hengshui People's Hospital (Harrison International Peace Hospital)-Endocrinology

Hengshui, Hebei, 053000, China
Huashan Hospital Fudan University-Endocrinology

Shanghai, Shanghai Municipality, 200040, China
Inner Mongolia People's Hospital-Endocrinology

Hohhot, Inner Mongolia, 010020, China
Instituto de Ciências Farmacêuticas de Estudos e Pesquisas

Aparecida de Goiânia, Goiás, 74935-530, Brazil
Jiangsu Province Hospital-Endocrinology

Nanjing, Jiangsu, 210029, China
Jinan Central Hospital

Jinan, Shandong, 250013, China
Prince of Wales Hospital

Shatin, New Territories, Hong Kong
Seoul National University Hospital

Seoul, 03080, South Korea
Shanghai Fifth People's Hospital-Endocrinology

Shanghai, Shanghai Municipality, 200240, China
Shanghai Pudong New Area People's Hospital-Endocrinology

Shanghai, Shanghai Municipality, 201200, China
Shanghai Tenth People's Hospital (Tenth People's of Tongji University)-Endocrinology

Shanghai, Shanghai Municipality, 200072, China
The Affiliated Hospital of Jiangsu University-Endocrinology

Zhenjiang, Jiangsu, 212001, China
The First Affiliated Hospital of Anhui Medical University-Endocrinology

Hefei, Anhui, 230061, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215006, China
The First Bethune hospital of Jilin University-Endocrinology

Changchun, Jilin, 130061, China
The Second Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, 650101, China
The Second Affiliated Hospital of Nanjing Medical University-Endocrinology

Nanjing, Jiangsu, 210011, China
The Second Hospital of Hebei Medical University-Endocrinology

Shijiazhuang, Hebei, 050000, China
The Second Hospital of Tianjin Medical University

Tianjin, Tianjin Municipality, 300211, China
The affiliated Hospital of Inner Mongolia Medical University-Endocrinology

Hohhot, Inner Mongolia, 010050, China
Tongren Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200336, China

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