New weekly injection could help shed pounds without diabetes

NCT ID NCT07232719

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 participants without type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if it is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: retatrutide
What this could lead to: If it works, this could provide a new weekly injection to help people with obesity or overweight lose significant body weight.
What could go wrong: This is a phase 3 trial, but results are not yet known. The drug may cause side effects, and weight loss may vary. It is not a cure for obesity, and long-term use may be needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Albany House Medical Centre

Wellingborough, NN8 4RW, United Kingdom
Artemis Institute for Clinical Research

Riverside, California, 92503, United States
Atlantic Medical

Penzance, TR18 3DX, United Kingdom
Bradford on Avon Health Centre

Bradford-on-Avon, BA15 1DQ, United Kingdom
Care Access - Arlington Heights

Arlington Heights, Illinois, 60005, United States
Care Access - Houston

Houston, Texas, 77054, United States
Care Access - Tamarac

Tamarac, Florida, 33321, United States
Cedar Health Research

Dallas, Texas, 75251, United States
Cedar Health Research - Euless

Euless, Texas, 76040, United States
Cedar Health Research - Fort Worth

Fort Worth, Texas, 76132, United States
Cheadle Community Hospital

Cheadle, ST10 1NS, United Kingdom
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Clinvest Headlands Llc

Springfield, Missouri, 65807, United States
FutureMeds - Birmingham

Birmingham, B21 9RY, United Kingdom
FutureMeds - Liverpool

Bromborough, CH62 6EE, United Kingdom
HMC Health Group - Meadows Centre for Health

Hounslow, TW4 7NR, United Kingdom
Headlands Research Orlando

Orlando, Florida, 32806, United States
Headlands Research-El Paso

El Paso, Texas, 79902, United States
IMA Clinical Research Manhattan

New York, New York, 10036, United States
IMA Clinical Research Monroe - Armand

Monroe, Louisiana, 71201, United States
IMA Clinical Research San Antonio

San Antonio, Texas, 78229, United States
IMA Clinical Research Warren

Warren Township, New Jersey, 07059, United States
JEM Research Institute

Atlantis, Florida, 33462, United States
L-MARC Research Center

Louisville, Kentucky, 40213, United States
Layton Medical Centre

Blackpool, FY3 7EN, United Kingdom
Pharmasite Research, Inc.

Baltimore, Maryland, 21208, United States
Rame Group Practice

Torpoint, PL11 2TB, United Kingdom
St Bartholomew's Medical Centre

Oxford, OX4 1XB, United Kingdom
The Adam Practice

Poole, BH16 5PW, United Kingdom
Trial Management Associates - Wilmington - Floral Parkway

Wilmington, North Carolina, 28403, United States
Woodstock Bower Surgery

Rotherham, S61 1AH, United Kingdom

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