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Weekly shot could ease back pain and help weight loss in large trial

NCT ID NCT07035093

Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests a once-weekly injection called retatrutide to see if it can reduce chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The goal is to find a new treatment option for those whose back pain is linked to excess weight.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 586 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a history of axial-predominant low back pain * Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs * Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening * Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight Exclusion Criteria: * Have a non-axial origin low back pain * Have had botulinum or steroid injections to the spine within 1 year of screening * Have had trigger point injection to the spine within 6 months of screening * Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days prior to screening * Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening * Have a prior or planned surgical treatment for obesity * Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low back pain (CLBP) Obesity Overweight

Contacts and locations

Locations

  • Aggarwal and Associates Limited

    Brampton, L6T 0G1, Canada

  • Alpine Clinical Research Center

    Boulder, Colorado, 80301, United States

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Ark Clinical Research - Fountain Valley

    Fountain Valley, California, 92708, United States

  • Artemis Institute for Clinical Research

    San Diego, California, 92123, United States

  • Bluewater Clinical Research Group Inc.

    Sarnia, N7T 4X3, Canada

  • CIPREC

    Buenos Aires, C1061AAS, Argentina

  • Care Access - Cape Breton

    Sydney, B1M 0A1, Canada

  • Care Access - Lake Charles (Bayou Pines)

    Lake Charles, Louisiana, 70601, United States

  • Care Access - Tampa

    Tampa, Florida, 33625, United States

  • Center for Clinical Research

    Winston-Salem, North Carolina, 27103, United States

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, C1425AGC, Argentina

  • Centro Médico Viamonte

    Buenos Aires, C1120AAC, Argentina

  • Centro Rosarino de Investigaciones Clinicas (CRICs)

    Rosario, 2000, Argentina

  • Centro de Diagnóstico y Rehabilitación (CEDIR)

    Santa Fe, 3000, Argentina

  • Centro de Investigaciones Clínicas Baigorria

    Granadero Baigorria, 2152, Argentina

  • Charter Research - Lady Lake

    The Villages, Florida, 32162, United States

  • Clinical Research Institute

    Los Angeles, California, 90048, United States

  • Clinvest Headlands Llc

    Springfield, Missouri, 65807, United States

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • Cotton O'Neil Clinical Research Center

    Topeka, Kansas, 66606, United States

  • Dr. Anil K. Gupta Medicine Professional Corporation

    Toronto, M9V 4B4, Canada

  • Flourish Research - Miami, LLC

    Miami, Florida, 33135, United States

  • Fundación Respirar

    Buenos Aires, C1426ABP, Argentina

  • FutureSearch Trials of Neurology

    Austin, Texas, 78731, United States

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • Houston Research Institute

    Houston, Texas, 77079, United States

  • IMA Clinical Research St. Petersburg

    St. Petersburg, Florida, 33704, United States

  • Instituto Médico Catamarca IMEC

    Rosario, 2000, Argentina

  • Investigaciones Medicas Imoba Srl

    Buenos Aires, C1056ABH, Argentina

  • K2 Medical Research - Daytona Beach

    Daytona Beach, Florida, 32114, United States

  • MD First Research - Chandler

    Chandler, Arizona, 85286, United States

  • MedVadis Research Corporation

    Waltham, Massachusetts, 02451, United States

  • Mercy Family Clinic

    Dallas, Texas, 75208, United States

  • New Phase Research and Development

    Knoxville, Tennessee, 37909, United States

  • Podlaskie Centrum Psychogeriatrii

    Bialystok, 15-756, Poland

  • Sovah Clinical Research-River District

    Danville, Virginia, 24541, United States

  • St Joseph Heritage Healthcare

    Fullerton, California, 92835, United States

  • Tucson Orthopaedic Institute - North Wyatt Drive

    Tucson, Arizona, 85712, United States

  • Winterberry Research Inc.

    Hamilton, L8J 0B6, Canada

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