CHRONIC LOW BACK PAIN (CLBP)

This study is testing whether a special ultrasound measurement, called the NUN biomarker, can track changes in chronic low back pain after a treatment called dry needling. Researchers want to see if this scan can predict which patients will feel better after treatment. They will …

This study is testing whether a specific hands-on therapy called Pelvic External Myofascial Mobilization (PEMM), combined with core exercises, can help women who suffer from both chronic low back pain and urinary incontinence. Researchers will compare this approach to standard pa…

This study is testing if a more holistic physical therapy approach works better than standard therapy for chronic low back pain. Researchers will compare a program that includes exercises, pain education, and coping strategies against a standard exercise-focused program. They aim…

This study is testing a new type of spinal cord stimulation device designed to ease chronic low back pain. It will involve about 30 adults who already get significant pain relief from a similar implanted device. Researchers want to see if this new approach is safe and works bette…

This study aims to understand how dry needling works to relieve chronic low back pain. Researchers will examine factors like muscle stiffness, mobility, and pain sensitivity in 71 adults with persistent back pain. By identifying what makes the treatment effective, they hope to de…

This study is testing whether a short, online behavioral therapy program delivered via Zoom can help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to teach participants strategies to reduce their pain intensity, decrease pain-related …

This study is testing whether a treatment called JHG002 pharmacopuncture (small injections at specific points) works better than standard physical therapy with TENS for adults who have had low back pain for more than 6 months. 96 participants will be randomly assigned to receive …

This study aims to find out if a common procedure for chronic low back pain, called lumbar radiofrequency ablation, actually works better than a fake procedure. Researchers will compare two different techniques for the nerve-zapping treatment against a simulated version in 300 pe…

This study is testing whether adding meditation or pain education to a proven sleep therapy program can better reduce pain for adults who have both chronic low back pain and long-term insomnia. Researchers will compare three approaches: the standard sleep therapy alone, sleep the…

This study is testing a program that combines mindfulness therapy with exercise to help older adults better manage chronic low back pain. Researchers want to see if this approach reduces pain and improves daily function and quality of life more than standard back care education. …

This study is testing whether adding a non-invasive brain stimulation technique to a specialized form of physiotherapy can better help military veterans manage chronic low back pain. It will compare the combination treatment to the therapy alone and to standard physiotherapy. The…

This study is comparing two different types of physical therapy exercises to see which works better for female university students with chronic low back pain. Researchers will measure how the exercises affect back movement, stability, and endurance. The goal is to find the most e…

This study is testing whether a single session of isometric exercise can provide immediate relief for adults with chronic low back pain. Researchers will measure changes in pain sensitivity and intensity right after the exercise. The goal is to see if this type of exercise can be…

This study is testing whether a weekly injection called retatrutide can safely reduce chronic low back pain in adults who also have obesity or are overweight. Researchers will compare the injection to a placebo (a dummy treatment) in about 586 participants over 80 weeks. The main…

This study is testing whether adding Osteopathic Manipulative Therapy (OMT)—a set of hands-on techniques where a doctor moves muscles and joints—to the usual VA medical care helps veterans and service members with chronic low back pain. It's a small, early-stage trial with 48 par…

This study aims to find out if combining passive and active hamstring stretching works better than passive stretching alone for improving flexibility in people with chronic low back pain. Researchers will enroll 90 participants with low back pain lasting at least 3 months and mea…

This study aims to understand how physical exercise helps people with chronic low back pain. Researchers will compare a 12-week online exercise program to a waitlist group, measuring changes in pain, immune system activity, and brain function. The goal is to learn the biological …

This study aims to understand how chronic sleep problems and chronic low back pain are connected in the brain. Researchers will compare four groups of people—some with pain, some with insomnia, some with both, and healthy individuals—using brain scans, sleep studies, and pain sen…