CHRONIC LOW BACK PAIN (CLBP)

This study tests a procedure called lumbar radiofrequency ablation (LRFA) that uses heat to calm nerves causing chronic low back pain. About 300 adults with pain lasting at least 3 months will be randomly assigned to receive real LRFA (using one of two electrode types) or a simul…

This study tests if adding active movement to passive hamstring stretches improves flexibility more than passive stretching alone in people with chronic low back pain. Ninety adults aged 18-65 with long-term back pain and tight hamstrings will be randomly assigned to one of two s…

This small pilot study will test whether osteopathic manipulative treatment (OMT) focused on the legs and feet can reduce chronic low back pain and improve daily function. Twenty adults with long-term back pain will receive four OMT sessions over several weeks. Researchers will m…

This study looks at whether lumbar stabilization exercises or back endurance exercises are better at improving spine movement and stability in female university students with chronic low back pain. About 60 participants will be assigned to one of the two exercise groups. The goal…

This study looks at whether a single session of isometric exercise (holding a muscle contraction without moving) can quickly reduce pain sensitivity and pain intensity in adults with chronic low back pain. Researchers will measure pain thresholds before and after exercise in 90 p…

This study tests whether adding a non-invasive brain stimulation technique (rTMS) to a special type of physiotherapy can better reduce chronic low back pain and disability in military veterans. About 96 veterans with long-lasting back pain and high emotional distress will receive…

This study looks at whether adding Osteopathic Manipulative Therapy (OMT) — a hands-on treatment where a doctor gently moves muscles and joints — to standard VA care can improve pain and daily function for veterans and service members with chronic low back pain. About 48 adults w…

This study tests whether combining acceptance and commitment therapy (a mindfulness-based approach) with exercise classes can reduce pain and disability in older adults with chronic low-back pain. Researchers will enroll 100 people aged 60 and older who have had back pain for at …

This study tests a new type of spinal cord stimulation called MuscleSCS to see if it safely reduces chronic low back pain. About 30 adults who already have a spinal cord stimulator and get good pain relief from it will try this new stimulation pattern. Researchers will measure pa…

This study looks at whether adding a meditation program or extra pain education to standard sleep therapy can help reduce pain intensity in adults with chronic low back pain and insomnia. About 300 participants will receive cognitive behavioral therapy for insomnia, then be assig…

This study tests a therapy called PEMM (a type of hands-on muscle release) combined with strengthening exercises in women aged 18–65 who have both chronic low back pain and urinary incontinence. About 130 women will be randomly assigned to receive either PEMM plus exercises or st…

This study tests a treatment called JHG002 for people with chronic low back pain lasting 6 months or more. About 96 adults aged 19 to 69 with moderate to severe pain will receive the therapy. The main goal is to see if it reduces pain intensity after 6 weeks.

This study compares two treatments for chronic low back pain: routine physical therapy and a biopsychosocial approach that adds hands-on therapy, education, and mental strategies. Researchers will measure pain, disability, and social support in 80 adults with back pain lasting ov…

This study tests whether a short behavioral treatment delivered over Zoom can help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain learn ways to reduce pain and disability. About 125 participants will take part. The goal is to see if this approach i…

This study is testing whether a weekly injection called retatrutide can help reduce chronic low back pain in adults who have obesity or are overweight. The 80-week trial will compare the drug against a placebo in 586 participants to see if it improves pain and leads to weight los…

This study tests whether a special ultrasound measurement, called the NUN biomarker, can track changes in chronic low back pain after dry needling and predict who will feel better. Researchers will compare real dry needling to a sham (fake) version in 80 adults with muscle-relate…

This study looks at how a 12-week online exercise program changes the brain and immune system in people with chronic low back pain. Researchers will compare these changes to a group that does not exercise. The goal is to understand why exercise helps some people with back pain. P…

This study looks at how chronic sleep problems and long-term low back pain are connected in the brain. Researchers will use brain scans to measure chemicals and structures in key brain areas. The goal is to understand the relationship better, not to test a new treatment. About 80…

This study looks at how dry needling works to relieve chronic low back pain. Researchers will study 71 adults aged 18-65 who have had low back pain for at least 3 months. Participants will receive dry needling and complete surveys and tests to measure pain, muscle stiffness, and …