CHRONIC LOW-BACK PAIN (CLBP)

This study tests whether adding a bone-marrow concentrate injection during routine back surgery helps the spinal disc heal better. About 90 adults with a herniated disc will get either surgery alone or surgery plus the injection. Researchers will use MRI scans and pain questionna…

This trial tests a program called ENCompaSS that combines education, phone coaching, and self-management tips to help Veterans with long-term back pain. Participants are randomly assigned to either the program plus usual care or usual care alone. The study measures whether the pr…

This study tests two different doses of focal shock wave therapy in 60 adults with chronic low back pain lasting at least 12 weeks. Participants receive the treatment and are monitored for pain relief and improved daily function. The goal is to find which dosing works better for …

This pilot study tests whether a wearable device that gently stimulates a nerve in the ear can help people with chronic low back pain. Half of the 44 participants will receive standard care (physical therapy, exercise, and education) plus the device; the other half will receive s…

This study tests whether combining electroacupuncture (using mild electric pulses on needles) with ear acupressure (using small seeds on ear points) can reduce pain and improve function in people with chronic low back pain. 76 adults aged 40-70 with pain lasting at least 12 weeks…

This study will test different exercise programs for adults aged 40 to 60 with chronic low back pain. Participants will be assigned to gym-based resistance training, physiotherapy exercises, or home-based routines, some with a special belt that gives feedback on core muscle activ…

This study looks at whether a special dry needling technique, called connective tissue dry needling, can help people with long-term low back pain caused by a specific spot near the hip bone. About 42 adults will either get the needling plus exercises, or just exercises, for two w…

This study tests whether adding percussive massage (using a device like a massage gun) with a heat attachment to standard exercise and TENS therapy can reduce pain and disability in people with chronic low back pain. 48 adults aged 25-55 with pain lasting at least 3 months will b…

This study tests whether a single dose of psilocybin can help people with chronic low back pain become more aware of their body, which may lead to better pain relief and improved results from physical therapy. About 45 adults aged 18-65 with long-lasting back pain will receive ps…

This study tests a virtual reality (XR) rehab program for people with chronic low back pain. About 314 adults will either get the XR program (including home exercises with avatars and activity tracking) or standard group therapy. The goal is to see if XR reduces pain, disability,…

This study looks at whether using a distraction app during exercise helps people with long-term low back pain stick with their workouts. Researchers will track 60 adults to see if better adherence leads to less pain and improved daily function. The goal is to find a simple way to…

This study compares virtual reality-based exercises to standard physical therapy for people with chronic low back pain. About 48 adults aged 18-65 will do either VR games or conventional exercises for 8 weeks. Researchers will measure changes in muscle thickness, balance, pain, a…

This pilot study will enroll 110 adults with chronic low back pain to see if their voice recordings can reveal how much pain they are in. Participants will read a short text aloud, and researchers will analyze features like pitch and speech rate. The goal is to compare these voic…

This study will follow 600 adults with low back pain (300 with acute pain, 300 with chronic pain) for 6 months. Participants will use a smartphone app to report pain, fear, and disability, and wear an activity tracker to measure movement and heart rate. The goal is to understand …