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Mind over back pain: brain retraining therapy tested for chronic sufferers

NCT ID NCT07696741

Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Aug 18, 2026 · Updated 6 times

Summary

This pilot study tests whether Pain Reprocessing Therapy (PRT) — a psychological treatment that teaches people to reinterpret pain signals from the brain — is feasible and acceptable for working-age adults (18–65) with chronic low back pain. Participants are randomly assigned to either 8 weekly PRT sessions or a monitoring and education program. The study measures recruitment, retention, satisfaction, and changes in pain intensity and daily functioning, with follow-up at 3 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pain Reprocessing Therapy (psychological intervention)
What this could lead to
If effective, this therapy could offer a drug-free way to manage chronic low back pain by retraining how the brain processes pain signals.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. The therapy requires active participation and may not work for all types of back pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Working age adults (18-65) * Male or Female at birth * Persisting back pain for at least 3 months occurring at least half of the days in the past 6 months * Pain score of at least 4/10 (on a 10-point rating scale) * Ability to speak and understand English in order to follow study procedures and engage in study interventions. Exclusion Criteria: * Compensation seeking claim/litigation/WSIB claim * Severe active psychiatric disorders (e.g., psychosis, substance use disorder) * An active medical issue such as untreated inflammatory disorder (e.g. ankylosing spondylitis, psoriatic arthritis) * Active cancers affecting the spine or body * Unexplained unintended weight loss of 20 lbs. or more in the past year * Inability to control bowel or bladder, function * Individuals who have received or are currently receiving one-on-one or group psychotherapy for chronic low back pain within the past 2 years (e.g., mindfulness, meditation, cognitive behavioural therapy, acceptance and commitment therapy, pain reprocessing therapy, or emotional awareness and exposure therapy). * Logistical or technical barriers (e.g. transportation challenges, scheduling constraints, or difficulty using fitness trackers

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Conditions

The condition(s) this trial relates to.

agnosia Back Pain Chronic Pain Low Back Pain Nociplastic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low-back pain (CLBP) Nociplastic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Toronto Rehabilitation Institute - University Centre

    RECRUITING

    Toronto, Ontario, M5G 2A2, Canada

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