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Blood test may spot worn spinal discs behind chronic back pain

NCT ID NCT07807839

Knowledge-focused Sponsor: Keimyung University Dongsan Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This study looks at whether a protein called BDNF in the blood matches the degree of spinal disc wear seen on MRI and levels of an inflammation marker called IL-1β. Researchers will measure BDNF in blood samples from 59 people with low back or leg pain caused by disc degeneration or spinal stenosis. They want to see if BDNF could serve as a simple marker for disc damage and pain-related inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood sampling for BDNF measurement
What this could lead to
If BDNF levels track disc degeneration and inflammation, a simple blood test might help gauge low back pain severity or guide treatment.
What could go wrong
This is a small observational study, so it may not prove cause and effect. Blood BDNF may not reliably reflect what happens inside the disc.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 59 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

low back pain population with disc degeneration confirmed in MRI

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * lumbar disc herniation * lumbar spinal canal stenosis * patients who have MRI Exclusion Criteria: * spine fracture * spine infection * spine tumor * rhematoid arthritis * ankylosing spondylitis * systemic lupus erythematosus * peripheral neuropathy * fibromyalgia * patient taking antidepressant, antipsychotics, acetylcholiesterase inhibitor

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Conditions

The condition(s) this trial relates to.

Low Back Pain lumbar spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low-back pain (CLBP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ji Hee

    RECRUITING

    Daegu, Daegu, 42601, South Korea

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